Tetrazepam Allergy: A Case Series of Cutaneous Adverse Events

Patch testing in non‐immediate cutaneous adverse drug reactions: value of extemporaneous patch tests

“…This lower proportion may be explained by the recruitment of the tested patients in our series: we tested all patterns of CADR, including FDE, DIGAL, SJS/TEN, and erythrodermia, for which PTs are not very sensitive . Moreover, studies concerning PTs for CADRs showed that the value of the test depends on the initial clinical features and the suspected CADR drug . The results of our study, obtained with the same types of drugs and CADRs, were similar.…”

“…Conversely, numerous positive test results have been reported with low concentrations. For example, positive test results have been reported with tetrazepam or diazepam commercial medicine diluted to 30% by pharmacies, corresponding to active ingredient concentrations of 2% and 8%, according to the Brajon et al study . Moreover, positive test reactions to carbamazepine commercial medicine diluted to 30% were reported, corresponding to 0.1% and 1% of active drug .…”