Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

Yáñez-Mó, Marı́a; Barreiro, Olga; Gordon-Alonso, Mónica; Sala-Valdés, Mónica; Sánchez-Madrid, Francisco

doi:10.1016/j.tcb.2009.06.004

Cited by 508 publications

(371 citation statements)

References 140 publications

Supporting

Mentioning

363

Contrasting

Unclassified

Order By: Relevance

“…The latter are a superfamily of four-transmembrane proteins that number 33 in humans (12,13). Tetraspanins possess two extracellular regions, the larger of which has four to eight conserved cysteine residues that form structurally important disulfide bonds.…”

Section: A Disintegrin and Metalloprotease 10 (Adam10) Is A Ubiquitoumentioning

confidence: 99%

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

Haining

Yang

Bailey

et al. 2012

Journal of Biological Chemistry

141

201

View full text Add to dashboard Cite

Background: ADAM10 is a transmembrane metalloprotease that regulates development, inflammation, cancer, and Alzheimer disease. Results: The TspanC8 subgroup of tetraspanin membrane proteins interacts with and promotes ADAM10 maturation and cell surface localization. Conclusion: This study defines the TspanC8 tetraspanins as essential regulators of ADAM10. Significance: Focusing on specific TspanC8-ADAM10 complexes may allow ADAM10 therapeutic targeting in a cell typeand/or substrate-specific manner.

show abstract

Section: A Disintegrin and Metalloprotease 10 (Adam10) Is A Ubiquitoumentioning

confidence: 99%

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

Haining

Yang

Bailey

et al. 2012

Journal of Biological Chemistry

141

201

View full text Add to dashboard Cite

show abstract

“…Furthermore, tetraspanin-enriched microdomains have been implicated in clustering and routing of MHCII from the plasma membrane (Hammond et al 1998;Engering and Pieters 2001;Kropshofer et al 2002;Zilber et al 2005;Poloso et al 2006;Unternaehrer et al 2007). Tetraspanins belong to a family of proteins that span the membrane four times and are palmitoylated, a posttranslational modification that stimulates lateral partitioning into protein/lipid domains (Kovalenko et al 2004;Yáñez-Mó et al 2009). Most tetraspanins contain motifs for clathrin-mediated endocytosis (Berditchevski and Odintsova 2007) that potentially could assist the internalization of domain-associated molecules such as pMHCII.…”

Section: Trafficking Of Pmhciimentioning

confidence: 99%

MHC Class II Antigen Presentation by Dendritic Cells Regulated through Endosomal Sorting

Broeke

Wubbolts

Stoorvogel

2013

Cold Spring Harbor Perspectives in Biology

135

View full text Add to dashboard Cite

For the initiation of adaptive immune responses, dendritic cells present antigenic peptides in association with major histocompatibility complex class II (MHCII) to naïve CD4 þ T lymphocytes. In this review, we discuss how antigen presentation is regulated through intracellular processing and trafficking of MHCII. Newly synthesized MHCII is chaperoned by the invariant chain to endosomes, where peptides from endocytosed pathogens can bind. In nonactivated dendritic cells, peptide-loaded MHCII is ubiquitinated and consequently sorted by the ESCRT machinery to intraluminal vesicles of multivesicular bodies, ultimately leading to lysosomal degradation. Ubiquitination of newly synthesized MHCII is blocked when dendritic cells are activated, now allowing its transfer to the cell surface. This mode of regulation for MHCII is a prime example of how molecular processing and sorting at multivesicular bodies can determine the expression of signaling receptors at the plasma membrane.

show abstract

“…Tetraspanins modulate the function of adhesion receptors involved in inflammation, lymphocyte activation, cancer and pathogen infection (Yàñez-Mó et al 2009). The histocompatibility 2, Q region locus 10 (H2-Q10) is one of the MHC class I molecules that mediate the interactions of leukocytes with other immune system and somatic cells.…”

Section: Identification Of Genes In the Cecum Affected By High-fat Dietmentioning

confidence: 99%

“…Conversely, Tspan4 is up-regulated by HFD. Among the functions of the tetraspanin trans-membrane protein, there is the modulation of the avidity of adhesion receptors involved in inflammation, and the regulation of cell migration and invasion (Yàñez-Mó et al 2009). The HFD seems therefore on the one side to pave the way to an inflammatory response and on the other to weaken the potential reaction to the onset of an inflammatory status.…”

Section: Gene Expressionmentioning

confidence: 99%

The nutrigenomic investigation of C57BL/6N mice fed a short-term high-fat diet highlights early changes in clock genes expression

et al. 2013

View full text Add to dashboard Cite

Mice fed long-term high-fat diets (HFD) are an established model for human metabolic disorders, such as obesity and diabetes. However, also the effects of shortterm HFD feeding should be investigated to understand which are the first events that trigger the onset of a predisease condition, the so-called metabolic syndrome, that increases the risk of developing clinical diseases. In this study, C57BL/6N mice were fed a control diet (CTR) or a HFD for 1 (T1) or 2 weeks (T2). Metabolic and histological effects were examined. Cecum transcriptomes of HFD and CTR mice were compared at T2 by microarray analysis. Differentially expressed genes were validated by real-time PCR in the cecum and in the liver. After 2 weeks of diet administration, HFD mice showed an altered expression pattern in only seven genes, four of which are involved in the circadian clock regulatory pathway. Real-time PCR confirmed microarray results of the cecum and revealed the same trend of clock gene expression changes in the liver. These findings suggest that clock genes may play an important role in early controlling gut output systems in response to HFD in mice and that their expression change may also represent an early signaling of the development of an intestinal pro-inflammatory status.

show abstract

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

Cited by 508 publications

References 140 publications

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

MHC Class II Antigen Presentation by Dendritic Cells Regulated through Endosomal Sorting

The nutrigenomic investigation of C57BL/6N mice fed a short-term high-fat diet highlights early changes in clock genes expression

Contact Info

Product

Resources

About