Tetraspanin CD81 promotes leukemia stem cell function and represents a new therapeutic vulnerability in acute myeloid leukemia
Fanny Gonzales,
Pauline Peyrouze,
Thomas Boyer
et al.
Abstract:Despite important progress over the last decade, acute myeloid leukemia (AML) is still associated with poor clinical outcome and novel efficient therapies ideally effective against AML stem cells (LSC), a major driver of leukemia initiation and progression, are urgently needed. In particular, targeting common AML-associated antigens at the stem and progenitor cell level represents an attractive therapeutic strategy to achieve deep long-term remissions and is currently the subject of intensive research efforts.… Show more
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