Cerebral palsy is a complex and serious disease that can affect all age groups around the world. There is no prevalence differentiation between developed and developing countries. Preeclampsia, maternal trauma, low birth weight, gestational age, birth asphyxia, intrauterine infection, etc. can also be included in the list of risk factors. Functional limitations, self-care difficulties, behavioral problems, seizures, cognitive, sensory, social and emotional impairments and difficulties of daily life activities can affect health-related quality of life in children and adolescents with cerebral palsy. So, it is important to evaluate health-related quality of life in cerebral palsy. It is stated that there are many generic instruments to evaluate health-related quality of life. However, using specific instruments for cerebral palsy is more sensitive than generic instruments to evaluate effect of cerebral palsy in children's health-related quality of life. The aim of this chapter is to investigate health-related quality of life instruments in children and adolescents with cerebral palsy.