Tetraphenylethene decorated with disulfide-functionalized hyperbranched poly(amido amine)s as metal/organic solvent-free turn-on AIE probes for biothiol determination

Wang, Bin; Li, Cheng; Yang, Lijun; Zhang, Congrou; Liu, Lijuan; Zhu, Sen; Chen, Yu; Wang, Yong

doi:10.1039/c9tb00214f

Cited by 17 publications

(8 citation statements)

References 50 publications

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“…The sensing of Cys results in the breaking of disulfide linkages, collapsing of the dendritic structure and the aggregation of TPE units to turn on blue fluorescence. 85…”

Section: Sensing Of Biomoleculesmentioning

confidence: 99%

Recent advances in aggregation-induced emission (AIE)-based chemosensors for the detection of organic small molecules

Chua,

Hui,

Chin

et al. 2023

Mater. Chem. Front.

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“…The sensing of Cys results in the breaking of disulfide linkages, collapsing of the dendritic structure and the aggregation of TPE units to turn on blue fluorescence. 85…”

Section: Sensing Of Biomoleculesmentioning

confidence: 99%

Recent advances in aggregation-induced emission (AIE)-based chemosensors for the detection of organic small molecules

Chua,

Hui,

Chin

et al. 2023

Mater. Chem. Front.

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“…Wang et al designed and synthesized a series of AIE-active polymer probes for biothiol detection. [159] The AIE polymers were composed of disulfide-functionalized hyperbranched poly(amido amine) as the hydrophilic group, TPE as the hydrophobic core and a disulfide bond as the cleavable functional linkage. Upon exposure of the AIE polymer solution to glutathione or cysteine, 'turn-on' bright fluorescence was observed, which was attributed to the degradation of the dendritic structure and subsequent aggregation of the TPE moieties.…”

Section: Biosensing Bio-imaging and Bio-trackingmentioning

confidence: 99%

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

et al. 2021

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Aggregation-induced emission (AIE) is a phenomenon in which fluorescence is enhanced rather than quenched upon molecular assembly. AIE fluorogens (AIEgens) are flexible, conjugated systems that are limited in their dynamics when assembled, which improves their fluorescent properties. This intriguing feature has been incorporated in many different molecular assemblies and has been extended to nanoparticles composed of amphiphilic polymer building blocks. The integration of the fascinating AIE design principle with versatile polymer chemistry opens up new frontiers to approach and solve intrinsic obstacles of conventional fluorescent materials in nanoscience, including the aggregation-caused quenching effect. Furthermore, this integration has drawn significant attention from the nanomedicine community, due to the additional advantages of nanoparticles comprising AIEgenic molecules, such as emission brightness and fluorescence stability. In this regard, a range of AIEgenic amphiphilic polymers have been developed, displaying enhanced emission in the self-assembly/aggregated state. AIEgenic assemblies are regarded as attractive nanomaterials with inherent fluorescence, which display promising features in a biomedical context, for instance in biosensing, cell/tissue imaging and tracking, as well as (photo) therapeutics. In this review, we describe recent strategies for the design and synthesis of novel types of AIEgenic amphiphilic polymers via facile approaches including direct conjugation to natural/synthetic polymers, polymerization, post-polymerization and supramolecular host−guest interactions. Their self-assembly behavior and biomedical potential will be discussed.

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“…Fluorescence sensing is another typical sensing system. Various fluorescent materials, such as organic dyes, [16,17] quantum dots, [18] carbon dots, [19] nanoclusters [20,21] have been utilized to construct fluorescence sensors. Most of these materials are quite stable and can be easily dispersed in the matrix, which endows fluorescence sensors with excellent precision and repeatability.…”

Section: Introductionmentioning

confidence: 99%

Dual‐mode color‐changing pH sensor based on fluorescent MOF embedded photonic crystal hydrogel

Tao

Wang

2022

J Chinese Chemical Soc

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In this work, a novel pH-responsive hybrid hydrogel namely MOF/PC hydrogel was prepared by incorporating metal-organic framework CDs@UiO-66 (OH) 2 into the matrix of photonic crystal hydrogel. MOF/PC hydrogel could display colorful structure colors under visible light and emit blue fluorescence under UV light owing to the stop-bond effect of photonic crystal and fluorescence emission capacity of CDs@UiO-66(OH) 2 , respectively. Benefiting from these two optical phenomena, MOF/PC hydrogel could work as a dual-mode color-changing sensor, in structure color mode and fluorescence mode, for the sensing of pH. When incubating in aqueous solutions with different pH values, MOF/PC hydrogel could adjust its structure color to the corresponding one ranging from green to pink in 10 s, and this visible color-changing can be used to determine the approximate pH values of the sample by naked eyes without any assistance of instruments. As for the fluorescence mode, the fluorescence intensity of MOF/PC hydrogel showed a good linear relationship with pH value in the range of 3.0$7.0, and it can be used to determine the pH value of aqueous solutions quantitatively. Moreover, the as-prepared sensor is reusable and can be applied to the pH sensing of real water samples.

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Tetraphenylethene decorated with disulfide-functionalized hyperbranched poly(amido amine)s as metal/organic solvent-free turn-on AIE probes for biothiol determination

Abstract: Novel hyperbranched poly(amido amine)s AIE probes were developed for organic solvent-free biothiol sensing.

Cited by 17 publications

References 50 publications

Recent advances in aggregation-induced emission (AIE)-based chemosensors for the detection of organic small molecules

Recent advances in aggregation-induced emission (AIE)-based chemosensors for the detection of organic small molecules

Amphiphilic AIEgen‐polymer aggregates: Design, self‐assembly and biomedical applications

Dual‐mode color‐changing pH sensor based on fluorescent MOF embedded photonic crystal hydrogel

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