Tetraoxygenated naturally occurring xanthones

Peres, Valdir; Nagem, Tânus Jorge

doi:10.1016/s0031-9422(00)00303-4

Cited by 357 publications

(200 citation statements)

References 296 publications

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“…IR data were recorded using a Nicolet Magna-IR 750 spectrophotometer. 1 H and 13 C NMR data were acquired with Varian Mercury-400, -500, and -600 spectrometers using solvent signals (acetone-d 6 Extraction and Isolation. The fermented material was extracted with EtOAc (4 × 1.0 L), and the organic solvent was evaporated to dryness under vacuum to afford the crude extract (5 0.0 g), which was fractionated by silica gel VLC using petroleum ether-EtOAc gradient elution.…”

Section: Methodsmentioning

confidence: 99%

Oxepinochromenones, Furochromenone, and their Putative Precursors from the Endolichenic Fungus Coniochaeta sp.

et al. 2010

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Six new polyketides including four oxepinochromenones, conioxepinols A−D (1−4), one furochromenone, coniofurol A (5), and one xanthone, conioxanthone A (6), have been isolated from the crude extract of the endolichenic fungus Coniochaeta sp. The absolute configurations of C-7 in 1 and the 7,8-diol moiety in 3 were assigned using the modified Mosher’s and Snatzke’s method, respectively, whereas that of C-8 in 5 was deduced via the circular dichroism data of the [Rh2(OCOCF3)4] complex. Compounds 2−4 showed modest cytotoxicity against a small panel of human tumor cell lines.

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Section: Methodsmentioning

confidence: 99%

Oxepinochromenones, Furochromenone, and their Putative Precursors from the Endolichenic Fungus Coniochaeta sp.

et al. 2010

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“…Xanthones, a widespread polyphenolic compound in plants, have extensive pharmacological activities such as antioxidant, antihypertensive, inhibition of platelet aggregation, antiulcer, and anti-inflammatory (Peres et al, 2000;Librowski et al, 2005). Flavonoids are the major secondary metabolites class with several descriptions of antioxidant property which confers a therapeutic potential with anti-inflammatory effect (Rajendran et al, 2000;Li et al, 2002;Matsuda et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Preliminary study on the anti-inflammatory and antioxidant activities of the leave extract of Hyptis fruticosa Salzm. ex Benth., Lamiaceae

Andrade¹,

Oliveira²,

Santos³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Avaliação das atividades anti-inflamatória e antioxidante do extrato etanólico das folhas da Hyptis fruticosa Salzm. ex Benth., Lamiaceae". Várias espécies do gênero Hyptis são utilizadas na medicina popular para tratar processos inflamatórios. Para avaliar as ações anti-inflamatória e antioxidante da Hyptis fruticosa Salzm. ex Benth., Lamiaceae, utilizou-se extrato etanólico (EE) das folhas desta planta e suas partições n-C 6 H 14 , CHCl 3 , AcOEt e MeOH/H 2 O. O tratamento oral com o EE das folhas da H. fruticosa (100, 200 e 400 mg/kg) ou suas partições n-C 6 H 14 , AcOEt e MeOH/H 2 O (50, 100 e 200 mg/kg) apresentou atividade inibitória sobre a formação de edema e migração leucocitária para a cavidade peritoneal induzidas pela carragenina em ratos (p<0,05). Entretanto, a partição CHCl 3 não causou nenhum efeito sobre a formação de edema e migração de células peritoneais. O EE bruto e a partição AcOEt apresentaram alto potencial antioxidante (IC50 = 35,00±1,01 e 36,67±2,65 μg/mL DPPH, respectivamente), similar ao composto referência (IC50 = 16,67±1,21 μg/mL). Em conclusão, demonstrou-se que a H. fruticosa apresenta atividades anti-inflamatória e antioxidante.Unitermos: Anti-inflamatória, antioxidante, edema, Hyptis fruticosa, Lamiaceae, migração celular.ABSTRACT: Various species of Hyptis are used in folk medicine as anti-inflammatory. In order to evaluate the actions of Hyptis fruticosa Salzm. ex Benth., Lamiaceae, studies were performed on anti-inflammatory and antioxidant activities. The ethanol extract (EE) of H. fruticosa leaves and its n-C 6 H 14 , CHCl 3 , EtOAc, and MeOH/H 2 O partitions were used in the following experiments. Oral treatment with the EE of H. fruticosa leaves (100, 200, and 400 mg/kg) or its n-C 6 H 14 , EtOAc, and MeOH/H 2 O partitions (50, 100, and 200 mg/kg) elicited inhibitory activity (p<0.05) on carrageenan-induced oedema formation and leukocyte migration into the peritoneal cavity in rats. However, the CHCl 3 partition did not show any inhibitory effect on paw oedema and peritonitis experimental models. The EE and EtOAc partition present the highest antioxidant potential (IC50 = 35.00±1.01 and 36.67±2.65 μg/ mL DPPH, respectively), similar to the reference compound (IC50 = 16.67±1.21 μg/mL). In conclusion, H. fruticosa shows anti-inflammatory and antioxidant activities.

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“…The presence of high levels of xanthones in mangosteen fruit rinds was reported by several research groups (Ee et al, 2006;Peres et al, 2000;Zhang et al, 2010). α-mangostin was the first xanthone isolated from G. mangostana and several other xanthones were isolated as well (Pedraza-Chaverri et al, 2008).…”

Section: Introductionmentioning

confidence: 88%

Antitumorigenicity of xanthones-rich extract from Garcinia mangostana fruit rinds on HCT 116 human colorectal carcinoma cells

Aisha¹,

Abu‐Salah²,

Nassar³

et al. 2011

Rev. bras. farmacogn.

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This study aimed to investigate the antitumorigenicity of xanthones-rich extract from Garcinia mangostana L., Clusiaceae, fruit rinds which was obtained by a simple recrystallization of 75% ethanolic extract. α-Mangostin content of the extract was determined qualitatively by TLC and quantitatively by HPLC, and total xanthones content was quantified by UV spectrophotometry. The extract was evaluated for cytotoxicity, apoptosis and antitumorigenicity on HCT 116 human colorectal carcinoma cells. α-Mangostin was found to be the main constituent of the extract which was 71.2±0.1%, and the total xanthones content was 95±4.8% (wt/ wt). The extract showed potent dose dependent cytotoxicity with IC50 value 9.2 µg/ mL. Apoptosis studies revealed activation of caspases 3 and 7, DNA fragmentation, chromatin condensation and loss of mitochondrial membrane potential. Studies on cell migration and colony formation indicate reduced cell migration ability and clonogenicity of treated HCT 116 cells at sub-inhibitory concentrations. Taken together, the cytotoxic effect of the xanthones extract is mediated through the mitochondrial pathway of apoptosis. The reduced cell migration and clonogenicity of HCT 116 cells might prevent both primary and metastatic tumor growth in vivo which will be the topic of our future work using the metastatic orthotopic colon cancer model.

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Tetraoxygenated naturally occurring xanthones

Cited by 357 publications

References 296 publications

Oxepinochromenones, Furochromenone, and their Putative Precursors from the Endolichenic Fungus Coniochaeta sp.

Oxepinochromenones, Furochromenone, and their Putative Precursors from the Endolichenic Fungus Coniochaeta sp.

Preliminary study on the anti-inflammatory and antioxidant activities of the leave extract of Hyptis fruticosa Salzm. ex Benth., Lamiaceae

Antitumorigenicity of xanthones-rich extract from Garcinia mangostana fruit rinds on HCT 116 human colorectal carcinoma cells

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