Tetranectin in cerebrospinal fluid: Biochemical characterisation and evidence of intrathecal synthesis or selective uptake into CSF

Stoevring, Birgitte; Jaliashvili, Irakli; Thougaard, Annemette; Ensinger, Christian; Høgdall, Claus; Rasmussen, Lars S.; Sellebjerg, Finn; Christiansen, Michael

doi:10.1016/j.cccn.2005.03.034

Cited by 12 publications

(7 citation statements)

References 32 publications

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“…Inconsistent with that study, Stoevring et al. clearly showed that tetranectin was present in normal CSF at a concentration of approximately 0.5 mg/l (32). Our results, detected by 2D DIGE and confirmed by Western blotting, showed tetranectin to be present in all normal CSF samples that is in agreement with the latter findings.…”

Section: Discussionmentioning

confidence: 66%

“…The role of tetranectin in neurodegenerative diseases is not clear. Previous study indicated that tetranectin was expressed in neurons and dendrites but not in glial cells in the cerebrum and cerebellum (32). It was also considered that tetranectin was involved in the degradation of neuron in brain (34) and that tetranectin in CSF was synthesized in the central nervous system (32).…”

Section: Discussionmentioning

confidence: 98%

“…Previous study indicated that tetranectin was expressed in neurons and dendrites but not in glial cells in the cerebrum and cerebellum (32). It was also considered that tetranectin was involved in the degradation of neuron in brain (34) and that tetranectin in CSF was synthesized in the central nervous system (32). PD is characterized by a progressive loss of dopaminergic neurons in brain, the decreased tetranectin levels in PD CSF might be a reflection of the process of pathogenesis.…”

Section: Discussionmentioning

confidence: 98%

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Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease

Wang

Sun

Guo

et al. 2010

Acta Neurologica Scandinavica

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

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Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease

Wang

Sun

Guo

et al. 2010

Acta Neurologica Scandinavica

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“…One previous study indicated that tetranectin was involved in the degradation of extracellular matrix proteins in the brain [27]. Immunohistochemistry showed tetranectin immunoreactivity in neurons and dendrites, and a lack of staining in glial cells in the cerebrum and cerebellum, and the source of tetranectin in the CSF is believed to be the central nervous system [28]. Our previous study demonstrated that tetranectin was present at reduced levels in PD patients in comparison to normal controls [29].…”

Section: Discussionmentioning

confidence: 99%

Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation

Wang

Yao

Chen

et al. 2013

Cell Physiol Biochem

858

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Aims: To investigate alterations in protein expression associated with deep brain stimulation (DBS) in an attempt to elucidate possible mechanisms of action. Methods: Cerebrospinal fluid (CSF), obtained from six Parkinson's disease (PD) patients (pre- and post-DBS) and from six normal healthy controls, was studied for differentially expressed proteins. 2-D DIGE, in combination with MALDI-TOF and TOF-TOF Mass Spectrometry (MS) or ESI-MS, was used to identify the changed proteins (3 PD patients and 3 controls). Selected proteins were further studied using western blotting (6 PD patients and 6 controls). Results: Twenty-one proteins were identified after MS and protein database interrogation. Apart from apolipoprotein A-I (apoA-I), the expression levels of complement C4 (C4), IgA, tetranectin, and extracellular superoxide dismutase (EC-SOD), detected by western blotting, correlated well with the 2-D DIGE results. In the follow-up period, the expression levels of C4, apoA-I and IgA were stable whereas EC-SOD and tetranectin were significantly elevated. In addition, when DBS was ceased in one patient due to a suicide attempt, the levels of EC-SOD and tetranectin significantly decreased. Conclusion: Our preliminary results suggest that variations in the expression levels of EC-SOD and tetranectin in CSF is related to DBS.

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“…AJ277116). Its function is not quite clear yet, but it has been suggested to play a role in cellular immunity (Stoevring et al, 2005). In this study, we expressed recombinant cLL to investigate the structural and functional characteristics of this protein.…”

Section: Introductionmentioning

confidence: 99%

Chicken lung lectin is a functional C-type lectin and inhibits haemagglutination by influenza A virus

Hogenkamp

Isohadouten

Reemers

et al. 2008

Veterinary Microbiology

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Many proteins of the calcium-dependent (C-type) lectin family have been shown to play an important role in innate immunity. They can bind to a broad range of carbohydrates, which enables them to interact with ligands present on the surface of micro-organisms. We previously reported the finding of a new putative chicken lectin, which was predominantly localized to the respiratory tract, and thus termed chicken lung lectin (cLL). In order to investigate the biochemical and biophysical properties of cLL, the recombinant protein was expressed, affinity purified and characterized. Recombinant cLL was expressed as four differently sized peptides, which is most likely due to post-translational modification. Crosslinking of the protein led to the formation of two high-molecular weight products, indicating that cLL forms trimeric and possibly even multimeric subunits. cLL was shown to have lectin activity, preferentially binding to a-mannose in a calcium-dependent manner. Furthermore, cLL was shown to inhibit the haemagglutination-activity of human isolates of influenza A virus, subtype H3N2 and H1N1. These result show that cLL is a true C-type lectin with a very distinct sugar specificity, and that this chicken lectin could play an important role in innate immunity. #

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Tetranectin in cerebrospinal fluid: Biochemical characterisation and evidence of intrathecal synthesis or selective uptake into CSF

Cited by 12 publications

References 32 publications

Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease

Tetranectin and apolipoprotein A-I in cerebrospinal fluid as potential biomarkers for Parkinson’s disease

Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation

Chicken lung lectin is a functional C-type lectin and inhibits haemagglutination by influenza A virus

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