Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis

Teng, Guoqi; Svystonyuk, Daniyil A.; Mewhort, H.E.; Turnbull, Jeffrey; Belke, Darrell D.; Duff, Henry J.; Fedak, Paul W.M.

doi:10.1152/ajpheart.00126.2015

Cited by 33 publications

(28 citation statements)

References 36 publications

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“…After the injury, various peptide growth factors stimulate fibroblasts to migrate into the wound site and proliferate to reconstitute the various connective tissue components . A critical event in the process is the differentiation of fibroblasts into active‐phenotype myofibroblasts . This differentiation results in functional changes including increased proliferation, changes in the release of signaling molecules, and extracellular matrix deposition.…”

Section: Discussionmentioning

confidence: 99%

Matrine reduces susceptibility to postinfarct atrial fibrillation in rats due to antifibrotic properties

Yin

et al. 2018

Cardiovasc electrophysiol

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This study aimed to investigate whether matrine could prevent atrial fibrillation (AF) after myocardial infarction by reducing left atrial fibrosis, and to determine the underlying mechanisms in isolated cardiac fibroblasts (CFs). Five weeks after MI, matrine-treated rats had lower rates of AF inducibility and shorter AF duration than MI rats. Matrine improved the left atrial conduction velocity and homogeneity. Matrine decreased the fibrosis positive areas and the protein levels of type I collagen and type III collagen in the left atrium. Matrine inhibited CFs differentiation to myofibroblasts and the expression of transforming growth factor-beta 1 and matrix metalloproteinase 9. In vitro, matrine inhibited the CFs proliferation, migration, differentiation, and secretion ability. These in vitro and in vivo data demonstrated that matrine has the potential to reduce susceptibility to AF after MI due, at least in part, to reduced atrial fibrosis via inhibiting CFs proliferation, migration, differentiation, and secretion ability.

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Section: Discussionmentioning

confidence: 99%

Matrine reduces susceptibility to postinfarct atrial fibrillation in rats due to antifibrotic properties

Yin

et al. 2018

Cardiovasc electrophysiol

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“…Cell morphology and local ECM remodelling by individual myofibroblasts were assessed with the use of a noncontractile collagen gel model as previously described. 11 Morphologic parameters included cell area as determined with the use of the Multi-Cell outliner ImageJ plug-in, number of cell extensions, and length of extensions. Local ECM remodelling was quantified by assessment of collagen fibre alignment with the use of confocal reflectance microscopy and ImageJ software with the Oval Profile plug-in.…”

Section: Assessment Of Cell Morphology and Local Ecm Remodellingmentioning

confidence: 99%

“…Expression of a-SMA was characterized with the use of flow cytometry as previously described. 11 Western blot a-SMA expression and SMAD2/3 phosphorylation was characterized by means of Western blot analysis. the use of confocal microscopy.…”

Section: Alpha-smooth Muscle Actin (A-sma) Expression Characterizationmentioning

confidence: 99%

Direct Effects of Empagliflozin on Extracellular Matrix Remodelling in Human Cardiac Myofibroblasts: Novel Translational Clues to Explain EMPA-REG OUTCOME Results

Kang

Verma

Hassanabad

et al. 2020

Canadian Journal of Cardiology

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115

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“…Clinically, TED has been found to be effective for the treatment of inflammation, 1 , 2 pneumosilicosis, 3 and antitumor activity. 4 – 6 Numerous studies have reported that TED also acts as a nonselective calcium channel blocker 7 , 8 and calmodulin antagonist. 9 In addition, TED has exhibited excellent pharmacological effects, especially in treating pulmonary hypertension.…”

Section: Introductionmentioning

confidence: 99%

A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation

Guo

Cang

2016

DDDT

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In this study, novel tetrandrine-loaded chitosan microspheres were prepared by the emulsion cross-linking method. The systems were then characterized for physicochemical properties and in vitro drug release. In addition, the pharmacokinetics and tissue distribution of microspheres were further verified in animal models. Particle-size distribution indicated that the size of microspheres was within the range of 7–15 μm, with a median diameter of 12.4 μm. The drug loading and entrapment efficiency of the formulation were 34.6%±12.5% and 87.3%±9.7% (mean ± SD), respectively. In vitro release showed a typical sustained and long-term drug release behavior. The Higuchi equation was the model that fit best with release data. Maintaining a relatively constant plasma concentration in the long-term drug treatment is an outstanding pharmacokinetic advantage of tetrandrine microspheres in vivo. Moreover, compared with tetrandrine solution, tetrandrine microspheres produced a lower drug concentration in the heart, liver, and kidneys. This indicated that the microspheres used in this study were preferable for targeting lung tissue versus other tissues. No damage to the tissues of the lung was found in histopathological examination.

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Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis

Abstract: Teng G, Svystonyuk D, Mewhort HE, Turnbull JD, Belke DD, Duff HJ, Fedak PW. Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis.

Cited by 33 publications

References 36 publications

Matrine reduces susceptibility to postinfarct atrial fibrillation in rats due to antifibrotic properties

Matrine reduces susceptibility to postinfarct atrial fibrillation in rats due to antifibrotic properties

Direct Effects of Empagliflozin on Extracellular Matrix Remodelling in Human Cardiac Myofibroblasts: Novel Translational Clues to Explain EMPA-REG OUTCOME Results

A novel tetrandrine-loaded chitosan microsphere: characterization and in vivo evaluation

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