Tetrandrine

Huang, Yo-Ping; Hong, Chuang‐Ye

doi:10.1111/j.1527-3466.1998.tb00341.x

Cited by 26 publications

(27 citation statements)

References 36 publications

(20 reference statements)

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“…It is believed that proliferation of fibroblasts plays an important role in hypertrophic scar formation and is involved in reepithelialization, extracellular matrix (ECM) deposition, neovascularization, and ECM remodeling (van der Veer et al, 2009). Both experimental and clinical researchers have shown that tetrandrine, a bisbenzylisoquinoline alkaloid isolated from the root of Stephania tetrandra, exerted antiinflammatory properties, attenuated ECM deposition, and exhibited antifibrogenic activity against fibroblasts (Reist et al, 1993;Huang and Hong, 1998;Oh and Lee, 2003). Our previous studies have provided evidence that tetrandrine significantly inhibits proliferation of hypertrophic scar fibroblasts (HSFs) and decreases the expression of DNA (Liu et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro

Peng

Liu

et al. 2016

Genet. Mol. Res.

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ABSTRACT. MicroRNAs (miRNAs) have recently been shown to play a role in normal wound healing process. miRNAs may be linked to pathologic wound healing and closely related to the formation of hypertrophic scars. This study aimed to explore the effects of tetrandrine on the miRNA expression profile in human hypertrophic scar fibroblasts (HSFs) in vitro. HSFs were randomly divided into two groups: the tetrandrine treatment group and the control group. The experimental and control groups were collected and analyzed by miRNA array after a 48-h culture. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to confirm the array results. The targets of differentially expressed miRNA were functionally annotated using bioinformatic approaches. miRNA microarray analysis identified 193 differentially expressed miRNAs and the expression of 186 miRNAs in the experimental group decreased while that of 7 miRNAs increased compared to the control group. The most significantly downregulated miRNA was hsa-miR-1246, and hsa-miR-27b had the highest expression level. Significant differentially expressed miRNAs were predicted to be related to several important signaling pathways related to scar wound healing. The differential miRNA expression identified in this study provides the experimental basis for further understanding the antifibrosis effect of tetrandrine.

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Section: Introductionmentioning

confidence: 99%

Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro

Peng

Liu

et al. 2016

Genet. Mol. Res.

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“…The main ingredients in this herb are tetrandrine and fangchinoline (Sutter & Wang 1993). Tetrandrine works as a calcium entry blocker (Felix et al 1992), showing various actions, such as the modulation of cardiovascular disorders (Huang & Hong 1998), and anti-tumour (Lee et al 2002) and anti-inflammatory effects (Shen et al 1999). Fangchinoline is thought to be less potent than tetrandrine as a vasodilator or calcium channel blocker (Kim et al 1997).…”

Section: Introductionmentioning

confidence: 99%

The plasma glucose lowering action of tetrandrine in streptozotocin-induced diabetic rats

Chen

Hayakawa

Yamamoto

et al. 2004

Journal of Pharmacy and Pharmacology

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The effect of tetrandrine, an active principle of Stephaniae tetrandrae, on the plasma glucose level in streptozotocin-induced diabetic rats (STZ-diabetic rats) was investigated. A single intravenous injection of tetrandrine decreased the plasma glucose in a dose-dependent manner in STZ-diabetic rats. Moreover, tetrandrine (1.0 mg x kg(-1)) significantly attenuated the rise in plasma glucose induced by the intravenous glucose challenge test in normal rats. A stimulatory effect of tetrandrine on glucose uptake was obtained in soleus muscles isolated from STZ-diabetic rats with a concentration-dependent manner from 0.01 to 10.0 micromol L(-1). The increase in glucose utilization by tetrandrine was further characterized using the enhancement of glycogen synthesis in the hepatocytes of STZ-diabetic rats. These results suggest that tetrandrine has the ability to enhance glucose utilization in peripheral tissue, resulting in the lowering of plasma glucose in diabetic rats lacking insulin.

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“…The introduction of structurally new compounds as alternatives to existing antimicrobial agents enables the diversification of medicine and extends the shelf-life of available drugs and therapies, thereby delaying the MDR problem. TET has long generated considerable interest, mainly due to its cardiovascular electrophysiological properties as a Ca 2+ antagonist (Fang and Jiang, 1986;Sutter and Wang, 1993;Huang and Hong, 1998;Yao and Jiang, 2002). Therefore, it was considered that TET, which is a plant-based efflux pump inhibitor, might be a good candidate for clinical use as a resistance-modifying agent.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA)

et al. 2011

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-Methicillin-resistant Staphylococcus aureus (MRSA) along with other resistant bacteria have become a significant social and clinical problem. Therefore, there is an urgent need to develop bioactive compounds from natural products as alternatives to the very few antibiotics that remain effective. Recently, the efflux mechanism has been identified as the main contributor to antibiotic resistance in bacteria. This study therefore aimed to evaluate tetrandrine (TET), an efflux pump inhibitor (EPI), as a potential antibiotic against MRSA. We investigated the antimicrobial activity of TET against 17 MRSA strains, of which 3 selected strains were studied in further detail using a time-kill assay. When these bacterial strains (1 × 10 6 colony-forming units (cfu)/ml) were incubated with TET in a time-kill assay, log-scale bactericidal activity was observed, which lasted for 24 hr. In addition, TET exhibits a synergistic effect when combined with the multi-drug resistance (MDR)-efflux pump substrate ethidium bromide (EtBr). Structure-function studies of the antibiotic activity of TET in combination with EtBr may lead to the discovery of more effective efflux pump inhibitors.

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Tetrandrine

Cited by 26 publications

References 36 publications

Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro

Tetrandrine induces microRNA differential expression in human hypertrophic scar fibroblasts in vitro

The plasma glucose lowering action of tetrandrine in streptozotocin-induced diabetic rats

Synergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA)

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