Tetrandrine downregulates TRPV2 expression to ameliorate myocardial ischemia/reperfusion injury in rats via regulation of cardiomyocyte apoptosis, calcium homeostasis and mitochondrial function

Jiang, Lelin; Zhou, Xue; Zhao, Xiaoli; Wang, Zhaolin; Huang, Anwu; Huang, Yiwei; Sun, Huanghui; Guan, Fanlu; Jiang, Wenbing

doi:10.1016/j.ejphar.2023.176246

Cited by 3 publications

(1 citation statement)

References 46 publications

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“…Other studies have shown that downregulated TRPV2 can significantly inhibit ROS production and Ca 2+ concentration in cardiomyocytes. The inhibition of TRPV2 can decrease the apoptosis rate of cardiomyocytes treated with I/R and reduce heart damage [ 52 ].…”

Section: Ion Channel Changes After MImentioning

confidence: 99%

Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges

Song,

Hui,

Huang

et al. 2024

IJMS

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In different areas of the heart, action potential waveforms differ due to differences in the expressions of sodium, calcium, and potassium channels. One of the characteristics of myocardial infarction (MI) is an imbalance in oxygen supply and demand, leading to ion imbalance. After MI, the regulation and expression levels of K+, Ca2+, and Na+ ion channels in cardiomyocytes are altered, which affects the regularity of cardiac rhythm and leads to myocardial injury. Myocardial fibroblasts are the main effector cells in the process of MI repair. The ion channels of myocardial fibroblasts play an important role in the process of MI. At the same time, a large number of ion channels are expressed in immune cells, which play an important role by regulating the in- and outflow of ions to complete intracellular signal transduction. Ion channels are widely distributed in a variety of cells and are attractive targets for drug development. This article reviews the changes in different ion channels after MI and the therapeutic drugs for these channels. We analyze the complex molecular mechanisms behind myocardial ion channel regulation and the challenges in ion channel drug therapy.

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Section: Ion Channel Changes After MImentioning

confidence: 99%

Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges

Song,

Hui,

Huang

et al. 2024

IJMS

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Embryo thermal manipulation enhances mitochondrial function in the skeletal muscle of heat-stressed broilers by regulating transient receptor potential V2 expression

Li,

Wang

et al. 2024

Poultry Science

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TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity

Fricke,

Leffler

2024

J Physiol Sci

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Transient receptor potential (TRP) ion channels serve as sensors for variations in ambient temperature, modulating both thermoregulation and temperature responsive cellular processes. Among these, the vanilloid TRP subfamily (TRPV) comprises six members and at least four of these members (TRPV1-TRPV4) have been associated with thermal sensation. TRPV2 has been described as a sensor for noxious heat, but subsequent studies have unveiled a more complex role for TRPV2 beyond temperature perception. This comprehensive review aims to elucidate the intricate thermosensitivity of TRPV2 by synthesizing current knowledge on its biophysical properties, expression pattern and known physiological functions associated with thermosensation.

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Tetrandrine downregulates TRPV2 expression to ameliorate myocardial ischemia/reperfusion injury in rats via regulation of cardiomyocyte apoptosis, calcium homeostasis and mitochondrial function

Cited by 3 publications

References 46 publications

Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges

Dynamic Changes in Ion Channels during Myocardial Infarction and Therapeutic Challenges

Embryo thermal manipulation enhances mitochondrial function in the skeletal muscle of heat-stressed broilers by regulating transient receptor potential V2 expression

TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity

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