Tetramethylpyrazine: An Active Ingredient of Chinese Herbal Medicine With Therapeutic Potential in Acute Kidney Injury and Renal Fibrosis

Li, Jun; Gong, Xuezhong

doi:10.3389/fphar.2022.820071

Cited by 15 publications

(14 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacological studies have found that TMP inhibits platelet aggregation, reduces blood viscosity, scavenges free radicals, protects cardiovascular and cerebrovascular vessels, and dilates renal blood vessels ( Zhao et al, 2016 ). Given its antioxidant, anti-inflammatory, and anti-apoptotic effects, many studies have focused on the benefits of TMP in AKI ( Li and Gong, 2022 ). Cisplatin causes an increase in MDA, Nitric Oxide (NO), and inducible nitric oxide synthase (iNOS) levels and a decrease in GSH, GST, and SOD levels, which can be restored to near-normal levels by TMP intervention, suggesting that TMP inhibits oxidative stress, thus, has a dose-dependent protective effect against cisplatin-induced tubular toxicity ( Ali et al, 2008 ; Liu et al, 2008 ).…”

Section: Botanical Drug Metabolites With Research Potentialmentioning

confidence: 99%

“…At present, Chinese medicine has received strong support from the World Health Organization and is included in Chapter 26 of the 11th edition of the Global Medical Program. The renoprotective effects of some Chinese medicinal formulas and metabolites have received widespread attention and have been studied in multiple AKI models, including DI-AKI ( Wang et al, 2019 ; Li and Gong, 2022 ; Rui et al, 2022 ; Zou et al, 2022 ). In this review, whether Chinese meteria medica and their preparations or monomers can improve DI-AKI and their potential mechanisms of action were explored.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential therapeutic effects of Chinese meteria medica in mitigating drug-induced acute kidney injury

et al. 2023

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Drug-induced acute kidney injury (DI-AKI) is one of the leading causes of kidney injury, is associated with high mortality and morbidity, and limits the clinical use of certain therapeutic or diagnostic agents, such as antineoplastic drugs, antibiotics, immunosuppressants, non-steroidal anti-inflammatory drugs, and contrast media. In recent years, numerous studies have shown that many Chinese meteria medica, metabolites derived from botanical drugs, and Chinese medicinal formulas confer protective effects against DI-AKI by targeting a variety of cellular or molecular mechanisms, such as oxidative stress, inflammatory, cell necrosis, apoptosis, and autophagy. This review summarizes the research status of common DI-AKI with Chinese meteria medica interventions, including cisplatin, gentamicin, contrast agents, methotrexate, and acetaminophen. At the same time, this review introduces the metabolites with application prospects represented by ginseng saponins, tetramethylpyrazine, panax notoginseng saponins, and curcumin. Overall, this review provides a reference for the development of promising nephroprotectants.

show abstract

Section: Botanical Drug Metabolites With Research Potentialmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential therapeutic effects of Chinese meteria medica in mitigating drug-induced acute kidney injury

et al. 2023

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The progression of AKI-CKD transition is a complex process involving inflammatory damage, G2/M cell cycle arrest, and oxidative stress (OS), and these processes ultimately lead to or aggravate renal fibrosis. 4,5 Understanding the precise underlying molecular mechanisms of AKI-CKD transition is imperative for identifying early intervention options to improves patient prognosis. [6][7][8] Cellular senescence is involved in the pathomechanisms of different forms of kidney damage including AKI and CKD.…”

Section: Introductionmentioning

confidence: 99%

“…Renal maladaptive repair after AKI results in the development of renal interstitial fibrosis, supporting the existence of AKI‐CKD transition. The progression of AKI‐CKD transition is a complex process involving inflammatory damage, G2/M cell cycle arrest, and oxidative stress (OS), and these processes ultimately lead to or aggravate renal fibrosis 4,5 . Understanding the precise underlying molecular mechanisms of AKI‐CKD transition is imperative for identifying early intervention options to improves patient prognosis 6–8 …”

Section: Introductionmentioning

confidence: 99%

VNN1 contributes to the acute kidney injury–chronic kidney disease transition by promoting cellular senescence via affecting RB1 expression

Chen

Wang

et al. 2022

The FASEB Journal

View full text Add to dashboard Cite

The mechanisms underlying acute kidney injury (AKI) and chronic kidney disease (CKD) progression include interstitial inflammation, cellular senescence, and oxidative stress (OS). Although vanin-1 (VNN1) plays an important role in OS, its contribution to the AKI-CKD transition remains unknown. Here, we explored the roles and mechanisms of VNN1 in the progression of the AKI-CKD transition. We observed that VNN1 expression was upregulated after ischemia/ reperfusion (I/R) injury and high VNN1 expression levels were associated with poor renal repair after I/R injury. In VNN1 knockout (KO) mice, recovery of serum creatinine and blood urea nitrogen levels after I/R injury was accelerated and renal fibrosis was inhibited after severe I/R injury. Furthermore, in VNN1 KO mice, senescence of renal tubular cells was inhibited after severe I/R injury, as assessed by P16 expression and SA-β-Gal assays. However, our results also revealed that VNN1 KO renal tubular cells did not resist senescence when OS was blocked. To elucidate the mechanism underlying VNN1-mediated regulation of senescence during the AKI-CKD transition, retinoblastoma 1 (RB1) was identified as a potential target. Our results suggest that the reduced senescence in VNN1 KO renal tubular cells was caused by suppressed RB1 expression and phosphorylation. Collectively, our results unveil a novel molecular mechanism by which VNN1 promotes AKI-CKD transition via inducing senescence of renal tubular cells by activating RB1 expression and phosphorylation after severe renal injury. The present study proposes a new strategy for designing therapies wherein VNN1 can be targeted to obstruct the AKI-CKD transition.

show abstract

“…Tetramethylpyrazine (ligustrazine, TMP) is an alkaloid monomer extracted from the dried rhizome of the Chinese herbal medicine Ligusticum striatum DC . (Chuan Xiong) [ Figure 1 ( Li and Tetramethylpyrazine, 2022 )]. Chuan Xiong is a vital ingredient in Buyanghuanwu decoction, Houshiheisan, and Naoxintong capsules.…”

Section: Introductionmentioning

confidence: 99%

Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review

et al. 2022

View full text Add to dashboard Cite

Central nervous system (CNS) diseases can lead to motor, sensory, speech, cognitive dysfunction, and sometimes even death. These diseases are recognized to cause a substantial socio-economic impact on a global scale. Tetramethylpyrazine (TMP) is one of the main active ingredients extracted from the Chinese herbal medicine Ligusticum striatum DC. (Chuan Xiong). Many in vivo and in vitro studies have demonstrated that TMP has a certain role in the treatment of CNS diseases through inhibiting calcium ion overload and glutamate excitotoxicity, anti-oxidative/nitrification stress, mitigating inflammatory response, anti-apoptosis, protecting the integrity of the blood-brain barrier (BBB) and facilitating synaptic plasticity. In this review, we summarize the roles and mechanisms of action of TMP on ischemic cerebrovascular disease, spinal cord injury, Parkinson’s disease, Alzheimer’s disease, cognitive impairments, migraine, and depression. Our review will provide new insights into the clinical applications of TMP and the development of novel therapeutics.

show abstract

Tetramethylpyrazine: An Active Ingredient of Chinese Herbal Medicine With Therapeutic Potential in Acute Kidney Injury and Renal Fibrosis

Cited by 15 publications

References 122 publications

Potential therapeutic effects of Chinese meteria medica in mitigating drug-induced acute kidney injury

Potential therapeutic effects of Chinese meteria medica in mitigating drug-induced acute kidney injury

VNN1 contributes to the acute kidney injury–chronic kidney disease transition by promoting cellular senescence via affecting RB1 expression

Regulatory mechanisms of tetramethylpyrazine on central nervous system diseases: A review

Contact Info

Product

Resources

About