Tetramer monitoring to assess risk factors for recurrent cytomegalovirus reactivation and reconstitution of antiviral immunity post allogeneic hematopoietic stem cell transplantation

Borchers, Sylvia; Luther, Susanne; Lips, Ulrich; Hahn, N; Kontsendorn, Julia; Stadler, Michael; Buchholz, Stefanie; Diedrich, Helmut; Eder, Matthias; Koehl, Ulrike; Ganser, Arnold; Mischak-Weissinger, Eva

doi:10.1111/j.1399-3062.2011.00626.x

Cited by 49 publications

(68 citation statements)

References 40 publications

(53 reference statements)

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“…CMV infection after haplo-SCT continues to adversely affect transplant outcomes [1–4] despite the use of prophylactic or preemptive treatment [5]. Lack of CMV-specific immune recovery has been reported as consistently associated with relapses of CMV infection and the development of CMV disease after allogeneic stem cell transplantation [6–9]. Therefore, this review summarizes the kinetics of CMV-specific T cell recovery and its association with CMV infection after haplo-SCT.…”

Section: Introductionmentioning

confidence: 99%

Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation

Luo

Chang

Huang

2014

Journal of Immunology Research

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Cytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT). CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity conditioning. CMV infection commonly occurs following impaired IR of T cell and its subsets. Here, we discuss the factors that influence IR based on currently available evidence. Adoptive transfer of donor T cells to improve CMV-specific IR is discussed. One should choose grafts from CMV-positive donors for transplant into CMV-positive recipients (D+/R+) because this will result in better IR than would grafts from CMV-negative donors (D−/R+). Stem cell source and donor age are other important factors. Posttransplant complications, including graft-versus-host disease and CMV infection, as well as their associated treatments, should also be considered. The effects of varying degrees of HLA disparity and conditioning regimens are more controversial. As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection.

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Section: Introductionmentioning

confidence: 99%

Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation

Luo

Chang

Huang

2014

Journal of Immunology Research

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“…Different techniques for isolation and expansion of CMV-specific T-cells are emerging as the knowledge on immune-reconstitution post allogeneic HSCT and CMV biology is expanding. The ability to determine and monitor CMV-CTL levels in the blood of HSCT recipients would be a useful tool to identify patients with poor CMV-specific immune reconstitution at higher risk of developing CMV infection/reactivation and overt disease [125,126]. In selected patients such as recipients of T-cell depleted grafts, ATCT, based on CMV-CTL reconstitution kinetics, would be of value in the prophylactic and/or preemptive setting.…”

Section: Expert Commentarymentioning

confidence: 99%

Treatment of CMV infection after allogeneic hematopoietic stem cell transplantation

Madon

Giaccone

Festuccia

et al. 2016

Expert Review of Hematology

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“…40-70% der HCMV-seropositiven Patienten erkranken nach einer HSCT an einer HCMV-Infektion [7,[34][35][36][37][38][39]. Die HCMV-Infektion stellt mit die häufigste Todesursache bei Patienten nach allogener Stammzelltransplantation dar.…”

Section: Hcmv-infektionen Nach Allogener Hämatopoetischer Stammzelltrunclassified

Peptidselektive Isolierung unmanipulierter T-Zellen für die adoptive Immuntherapie

Blasczyk

2013

Transfusionsmedizin

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Zusammenfassung Infektionen oder Reaktivierungen durch persistierende Viren, wie z.?B. dem humanen Zytomegalievirus und dem Epstein-Barr-Virus, oder lytische Viren, wie z.?B. dem Adenovirus, k?nnen sehr problematisch sein und durch teils schwere Verl?ufe zur Sterblichkeit nach Stammzell- und Organtransplantation beitragen. Es konnte gezeigt werden, dass der adoptive Transfer von antigen- bzw. virusspezifischen T-Lymphozyten des seropositiven Spenders die spezifische Immunit?t im Patienten rekonstituiert und das Risiko einer Graft-versus-Host-Erkrankung minimal ist. Bereits eine geringe Zahl dieser antigenspezifischen T-Zellen f?hrt zu klinischen Ansprechraten. Effektive Verfahren zur Aufreinigung dieser Zellen und deren klinische Effizienz wurden gezeigt.

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Tetramer monitoring to assess risk factors for recurrent cytomegalovirus reactivation and reconstitution of antiviral immunity post allogeneic hematopoietic stem cell transplantation

Cited by 49 publications

References 40 publications

Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation

Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation

Treatment of CMV infection after allogeneic hematopoietic stem cell transplantation

Peptidselektive Isolierung unmanipulierter T-Zellen für die adoptive Immuntherapie

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