Tetralone Acids as Intermediates for the Synthesis of Podophyllotoxin Analogues.

Abstract

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4-Methoxy-3-methylbenzophenone

“…The title compound, (I), a benzophenone derivative, is an intermediate for the preparation of antimitiotic -apopicropodophyllin (Basavaraju & Anjanamurthy, 2003). Over 300 crystal structures of benzophenone derivatives in the Cambridge Structural Database (CSD, Version 5.26;Allen, 2002) highlight the importance of structural studies on such pharmaceutically useful compounds.…”

Synthesis and evaluation of antimitotic activity of new tetralone acid analogues of podophyllotoxin

“…In view of the above facts, it was decided to modify the structure of podophyllotoxin and synthesized tetralone acids as analogues [5][6][7][8]. They were synthesized by replacing 3,4,5-trimethoxyphenyl ring with cyclohexyl group in podophyllotoxin and 1,3-methylene dioxy ring with methoxy, methyl, thiomethyl group and hydrogen and fluorine elements and lactone ring with carboxylic acid group.…”

Regiospecific Synthesis of Carboxylated and Simple α-Tetralones with Homophthalates and Various Acrylates by a Simple Condensation Method

“…It has been reported that α-tetralones are the basic units of several tricyclic or tetracyclic natural products. 1,2 Notable work has been done by Vasavaraju et al 3 who have prepared some substituted tetralones and used them to construct various tricyclic products. In that particular work they have also reported the antimitotic activity of tetralones.…”

“…After that, until now, very little work has been reported on the efficient synthesis of tetralones. 1,3 In most cases, the routes are lengthy and are not general. An emerging group of antibiotics popularly known as angucyclines, active antitumor agents, in most cases contain a tetralone as one of the basic units.…”