Tetralogy of Fallot: Hypoxia, the villain of the story?
Carlos Ariel Bojórquez Martínez,
Ingrid Montserrat García Murillo,
Santiago Segón Mora
et al.
Abstract:BackgroundTetralogy of Fallot (ToF) is a cyanotic congenital heart disease, composed of four malformations: persistent communication between the right and the left ventricle, pulmonary stenosis, overriding aorta, and right ventricle hypertrophy. The etiology of this disease is not entirely known as yet, but it has been proposed that the pathology has genetic components. During embryonic development, the fetus is exposed to a physiological hypoxia to facilitate the formation of blood vessels and blood cells thr… Show more
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