Tetralogy of Fallot

Wilson, Richard D.; Ross, Oliver; Griksaitis, Michael

doi:10.1016/j.bjae.2019.07.003

Cited by 29 publications

(51 citation statements)

References 19 publications

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“…Ŭ ſƌƊźžź Ůźƅƅƈ (ŬŮ) -ƇźƃƉƈƒƂƊſƇƟƒź ƐƟźƇƈƌƂƑƇź żƊƈžƀſƇź żźžź ƋſƊƐƙ, ƙƄź ƏźƊźƄƌſƊƂƁƍƝƌƖƋƙ ƒƂƊƈƄƂƆ źƇźƌƈƆƟƑƇƂƆ ƋƉſƄ-ƌƊƈƆ Ɵ żƂƊźƀſƇƟƋƌƘ ƄƅƟƇƟƑƇƂƏ ƉƊƈƙżƟż, Ɠƈ Ɓźƅſ-ƀźƌƖ żƟž ƋƌƍƉſƇƙ ƋƌſƇƈƁƍ ƅſŽſƇſżƈƠ źƊƌſƊƟƠ (ťŚ). őƇƈžƟ ŬŮ Ɔƈƀſ ƉƈƝžƇƍżźƌƂƋƙ Ɓ ƟƇƒƂƆƂ żź-žźƆƂ ƋſƊƐƙ ƌź ƏƊƈƆƈƋƈƆƇƂƆ źƇƈƆźƅƟƙƆƂ, ƌź-ƄƂƆƂ ƙƄ ƋƂƇžƊƈƆ ŞźƍƇź, ƋƂƇžƊƈƆ ŞƟ-ŞƀƈƊžƀƟ, ŚƅźžƀƂƅƙ (VACTERL-źƋƈƐƟźƐƟƙ) [1,4,5,7].…”

Section: ƴǣǥǥǡunclassified

Tetrallogy of Fallot and hypertrophic cardiomyopathy. Unusual association

Malska¹,

Kuryliak²

2022

UJPP

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Tetrallogy of Fallot (ToF) is the most widespread congenital heart defect characterized by a wide anatomic spectrum and clinical manifestations, which depend on the degree of stenosis of the pulmonary artery, and can be associated with chromosomal abnormalities. Hypertrophic cardiomyopathy (HCM) is a rare genetic disorder that often occurs in the autosomal-dominant type and has a high risk of cardiac death and is associated with abnormalities in certain gene loci. Clinical case. We present this rare association in a 9-month-old girl, without previous history of heart defect, who was admitted to intensive care unit with a clinical presentation of severe hypoxic spell. A rare case of the combination of ToF and HCM has been reported in a 9-month-old child admitted to the reanimation department of the Lviv Regional Children’s Clinical Hospital «OKHMATDYT» for malignant and cyanotic attacks. The girl was hospitalized for reanimation in a jaundice-cyanotic crisis with a saturation rate of 44%. On examination, a pronounced sciatica, pallor and cyanosis of the lips were detected. Auscultatively, the heart tones were rhythmic, muffled, the heart rate - 202 beats per second, systolic murmur was detected on the left side of the chest 5/6 on the Levine scale. Electrocardiogram showed signs of systolic hypertension and hypertrophy of the right ventricle. 2D-echocardiographic examination revealed hypertrophy of the left and right ventricular walls and interventricular septum as well as signs of ToF. On the magnetic resonance imaging the diagnosis was confirmed. After the stabilization of the general condition the child was transported to the Center of Pediatric Cardiology and Cardiac Surgery in Kyiv for surgical treatment, where it was recommended to continue the medical treatment with beta-blockers. After 2 months, the 1-year-old child was operated on routinely - radical correction of ToF, the post-operative state was good. Conclusions. Association of ToF and HCM is extremely rare. ToF is often associated with chromosomal aberration, while hypertrophic cardiomyopathy associates with certain gene loci. Surgical treatment of ToF associated with HCM differs greatly from surgical treatment of usual ToF and physiology of both conditions have to be considered prior to the surgery, as combination of ToF and HCM is associated with high postoperative mortality, as the LVOT progresses and increased risk of development of ventricular arrhythmias and heart failure develops. The association between ToF and HCM is extremely rare. ToF is associated with chromosomal abnormalities, whereas HCM is associated with abnormalities in certain gene loci. The prognosis for patients with TF and HCM is associated with high postoperative mortality due to progression of obstruction of the left ventricular tract, development of ventricular arrhythmias and cardiovascular failure during the postoperative period. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: Tetrallogy of Fallot, hypertrophic cardiomyopathy, cyanotic spell, echocardiography, children.

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Section: ƴǣǥǥǡunclassified

Tetrallogy of Fallot and hypertrophic cardiomyopathy. Unusual association

Malska¹,

Kuryliak²

2022

UJPP

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“…20 A ventricular septal defect (VSD), overriding aorta, right ventricular (RV) outflow tract obstruction (RVOTO) which is often dynamic, and right ventricular hypertrophy (RVH) are the four cardinal characteristics of Tetralogy of Fallot. 21 A right-to-left shunt is possible with a VSD. Blood flow to the pulmonary circuit is restricted by the RVOTO.…”

Section: Tetralogy Of Fallotmentioning

confidence: 99%

“…The additional workload required to circulate blood to the right ventricular blockage and the aorta obstructing the flow of blood causes right ventricle hypertrophy. 13,21 A PDA may be needed by patients with Tetralogy of Fallot with severe RVOTO to provide adequate pulmonary blood flow; for instance a ductdependent circulation necessitates prostaglandin infusion (either alprostadil [prostin E1] or dinoprostone [prostin E2]) until more temporizing palliative procedures or definitive surgical procedures can be performed. 18,19 If spelling occurs frequently in infants with dynamic RVOTO, betablockade (e.g.…”

Section: Tetralogy Of Fallotmentioning

confidence: 99%

Disease-related malnutrition in congenital 27 heart disease: what is the risk and impact on patient’s outcomes?

Noormanto

2022

World Nutr J

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Congenital heart disease (CHD) is the most common congenital anomaly in newborn babies. Malnutrition is common in children with congenital heart disease and may contribute to adverse outcomes. Malnutrition in children with CHD has been link to increased morbidity and mortality. Nutritional assessment and intervention before and after surgery is recommended to improve poor outcomes. This review aims to provide information about common CHD in children and nutrition pre- and post-operative cardiac surgery.

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“…Tetralogy of Fallot (TOF) is one of the most common congenital heart diseases (CHD), with an estimated incidence of1 in 3500 people or 0.23 to 0.63 cases per 1000 births ( Forman et al, 2019 ). TOF originates from the uneven separation of bulbar and trunk arteries during embryonic development, resulting in malformations such as ventricular septal defects, obstruction of the right ventricular outflow tract, right ventricular hypertrophy, and override of the ventricular septum by the aortic root ( Wilson et al, 2019 ). At present, prenatal diagnosis of TOF mainly relies on fetal echocardiography.…”

Section: Introductionmentioning

confidence: 99%

Identification of circRNA–miRNA–mRNA Regulatory Network and Crucial Signaling Pathway Axis Involved in Tetralogy of Fallot

et al. 2022

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Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart diseases (CHD) worldwide; however, its pathogenesis remains unclear. Recent studies have shown that circular RNAs (circRNAs) act as “sponges” for microRNAs (miRNAs) to compete for endogenous RNA (ceRNA) and play important roles in regulating gene transcription and biological processes. However, the mechanism of ceRNA in TOF remains unclear. To explore the crucial regulatory connections and pathways of TOF, we obtained the human TOF gene, miRNA, and circRNA expression profiling datasets from the Gene Expression Omnibus (GEO) database. After data pretreatment, differentially expressed mRNAs (DEmRNAs), microRNAs (DEmiRNAs), and circRNAs (DEcircRNAs) were identified between the TOF and healthy groups, and a global triple ceRNA regulatory network, including circRNAs, miRNAs, and mRNAs based on the integrated data, was constructed. A functional enrichment analysis was performed on the Metascape website to explore the biological functions of the selected genes. Then, we constructed a protein-protein interaction (PPI) network and identified seven hub genes using the cytoHubba and MCODE plug-ins in the Cytoscape software, including BCL2L11, PIK3R1, SOCS3, OSMR, STAT3, RUNX3, and IL6R. Additionally, a circRNA–miRNA–hub gene subnetwork was established, and its enrichment analysis results indicated that the extrinsic apoptotic signaling pathway, JAK-STAT signaling pathway and PI3K-Akt signaling pathway may be involved in the pathogenesis of TOF. We further identified the hsa_circ_000601/hsa-miR-148a/BCL2L11 axis as a crucial signaling pathway axis from the subnetwork. This study provides a novel regulatory network for the pathogenesis of TOF, revealing the possible molecular mechanisms and crucial regulatory pathways that may provide new strategies for candidate diagnostic biomarkers or potential therapeutic targets for TOF.

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Tetralogy of Fallot

Cited by 29 publications

References 19 publications

Tetrallogy of Fallot and hypertrophic cardiomyopathy. Unusual association

Tetrallogy of Fallot and hypertrophic cardiomyopathy. Unusual association

Disease-related malnutrition in congenital 27 heart disease: what is the risk and impact on patient’s outcomes?

Identification of circRNA–miRNA–mRNA Regulatory Network and Crucial Signaling Pathway Axis Involved in Tetralogy of Fallot

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