Tetrahydrocurcumin Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets

Kim, S.S.; Jang, Hyuk-Jai; Oh, Moon Young; Lee, J.H.; Kang, Ki Sung

doi:10.1016/j.transproceed.2018.03.033

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…Multiple assays of several pro-inflammatory cytokines (IL‐1 α, G‐CSF, IL‐10, IL‐17A, IL‐1β, IL‐6, TNF‐α, IL‐4, GM‐CSF, IFN γ, IL‐2, IL‐5, IL‐13, IL‐12p70) demonstrated that both curcumin and nanocurcumin successfully reduce their production in pancreatic tissue in STZ-induced diabetes in mice 11. In vitro study reported that tetrahydrocurcumin (THC), one of the primary metabolites of curcumin, has antioxidant and anti-inflammatory activities reducing islet cell apoptosis and improving their viability after being exposed to TNF-α, interferon-β, and IL-1 73. A clinical study has already demonstrated that oral administration of curcumin combined with piperine could reduce the serum level of TNF-α in diabetic patients, after 12 weeks of treatment 74.…”

Section: Discussionmentioning

confidence: 99%

<p>Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus</p>

Bulboacă

Boarescu

Bolboacă

et al. 2019

IJN

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PurposeAnti-inflammatory proprieties of curcumin were proved to be useful in various diseases, including diabetes mellitus. The aim of this study was to assess the anti-inflammatory comparative effect of curcumin solution with liposomal curcumin formula, regarding the improvement of serum levels of TNF-α (tumor necrosis factor-alpha), IL-6 (interleukin), IL-1α, IL-1β, MCP-1 (monocyte chemoattractant protein-1) and RANTES in experimental diabetes, induced by streptozotocin (STZ), in rats.Materials and methodsSix groups of 7 rats were investigated regarding the effect of i.p. (intraperitoneal) administration of two concentrations of curcumin solution (CC1 and CC2) and two concentrations of liposomal curcumin (LCC1 and LCC2): group 1 – control group with i.p. administration of 1 mL saline solution, group 2 – i.p. STZ administration (60mg/kg bw, bw=body weight), group 3 – STZ+CC1 administration, group 4 – STZ+CC2 administration, group 5 – STZ+ LCC1 administration and group 6 – STZ+ LCC2 administration. The concentrations of curcumin formulas were 1 mg/0.1 kg bw for CC1 and LCC1 and 2 mg/0.1 kg bw for CC2 and LCC2, respectively. Serum levels of C-peptide (as an indicator of pancreatic function) and TNF-α, IL-6, IL-1α, IL-1β, MCP-1, and RANTES (as biomarkers for systemic inflammation) were assessed for each group.ResultsThe plasma level of C-peptide showed significant improvements when LCC was administrated, with better results for LCC2 when compared to LCC1 (P<0.003). LCC2 pretreatment proved to be more efficient in reducing the level of TNF-α (P<0.003) and RANTES (P<0.003) than CC2 pretreatment. Upon comparing LCC2 with LCC1 formulas, the differences were significant for TNF-α (P=0.004), IL-1β (P=0.022), and RANTES (P=0.003) levels.ConclusionLiposomal curcumin in a dose of 2 mg/0.1 kg bw proved to have an optimum therapeutic effect as a pretreatment in DM induced by STZ. This result can constitute a base for clinical studies for curcumin efficiency as adjuvant therapy in type 1 DM.

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Section: Discussionmentioning

confidence: 99%

<p>Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus</p>

Bulboacă

Boarescu

Bolboacă

et al. 2019

IJN

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“…Curcumin treatment also significantly increased cytokine (TNF-α, interferon-β, and IL-1β) treated glucose-induced insulin resistance, glutathione levels and reduced NO production. In addition, apoptosis, active caspase-9, activated caspase-3 and Bax protein levels were reduced with curcumin treatment, while anti-apoptotic Bcl-2 protein levels were increased, suggesting protection against cytokine-induced apoptosis ( Table 4) [115].…”

Section: Effects Of Curcumin: In Vitro Pancreatic Cell Studiesmentioning

confidence: 98%

“…Treatment of isolated pancreatic islets with tetrahydrocurcumin (THC; 12.5 µM), a metabolite of curcumin, for 24 h resulted in significantly increased glucose-induced insulin secretion [115]. Curcumin treatment also significantly increased cytokine (TNF-α, interferon-β, and IL-1β) treated glucose-induced insulin resistance, glutathione levels and reduced NO production.…”

Section: Effects Of Curcumin: In Vitro Pancreatic Cell Studiesmentioning

confidence: 99%

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

2020

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Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment strategies for T2DM and insulin resistance lack in efficacy resulting in the need for new approaches to prevent and manage/treat the disease better. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (I of II) summarizes the existing in vitro studies examining the antidiabetic effects of curcumin, while a second (II of II) review summarizes evidence from existing in vivo animal studies and clinical trials focusing on curcumin’s antidiabetic properties.

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“…Tetrahydrocurcumin (THC), the final hydrogenated metabolite of curcumin (active ingredient of Curcuma longa L.), has demonstrated very strong antioxidant properties. In an effort to decrease the ROS-mediated islet cell damage prior to transplantation, Kim et al cultured Balb/c mice islet cells for 24 h in a THC-supplemented medium, and exposed them to various cytokines [64]. They found that THC-treated cells had 1.3-fold greater glucose sensitivity and produced B-cell lymphoma 2 (BCL2) (antiapoptotic) along with protective caspase proteins [64].…”

Section: Isolation: Metabolic Challengesmentioning

confidence: 99%

“…In an effort to decrease the ROS-mediated islet cell damage prior to transplantation, Kim et al cultured Balb/c mice islet cells for 24 h in a THC-supplemented medium, and exposed them to various cytokines [64]. They found that THC-treated cells had 1.3-fold greater glucose sensitivity and produced B-cell lymphoma 2 (BCL2) (antiapoptotic) along with protective caspase proteins [64]. Although at the time of the study it was established that THC increased glutathione (GSH) (a low molecular weight antioxidant), Luo et al have recently demonstrated that this occurs specifically through the Nrf2/Keap1 pathway [65].…”

Section: Isolation: Metabolic Challengesmentioning

confidence: 99%

Potential Benefits of Nrf2/Keap1 Targeting in Pancreatic Islet Cell Transplantation

López

Lau

et al. 2020

Antioxidants

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Permanent pancreatic islet cell destruction occurs in type 1 diabetes mellitus (T1DM) through the infiltration of inflammatory cells and cytokines. Loss of β-cell integrity secondary to oxidation leads to an inability to appropriately synthesize and secrete insulin. Allogenic islet cell transplantation (ICT) has risen as a therapeutic option to mitigate problematic hypoglycemia. Nevertheless, during the process of transplantation, islet cells are exposed to oxidatively caustic conditions that severely decrease the islet cell yield. Islet cells are at a baseline disadvantage to sustain themselves during times of metabolic stress as they lack a robust anti-oxidant defense system, glycogen stores, and vascularity. The Nrf2/Keap1 system is a master regulator of antioxidant genes that has garnered attention as pharmacologic activators have shown a protective response and a low side effect profile. Herein, we present the most recently studied Nrf2/Keap1 activators in pancreas for application in ICT: Dh404, dimethyl fumarate (DMF), and epigallocatechin gallate (EGCG). Furthermore, we discuss that Nrf2/Keap1 is a potential target to ameliorate oxidative stress at every step of the Edmonton Protocol.

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Tetrahydrocurcumin Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets

Cited by 10 publications

References 28 publications

<p>Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus</p>

<p>Comparative Effect Of Curcumin Versus Liposomal Curcumin On Systemic Pro-Inflammatory Cytokines Profile, MCP-1 And RANTES In Experimental Diabetes Mellitus</p>

Antidiabetic Properties of Curcumin I: Evidence from In Vitro Studies

Potential Benefits of Nrf2/Keap1 Targeting in Pancreatic Islet Cell Transplantation

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