2023
DOI: 10.1016/j.fbio.2023.102591
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Tetrahydrocurcumin as a stable and highly active curcumin derivative: A review of synthesis, bioconversion, detection and application

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Cited by 7 publications
(6 citation statements)
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“…In summary, the highest curcumin titer was achieved by increasing the copy number of biosynthetic modules to balance metabolic flow and the fusion of DCS and CURS1, eliminating repression of the β-oxidation pathway, suppressing the consumption of malonyl-CoA by E. coli, and expressing the srpB efflux pump to alleviate the toxicity of biosynthetic pathway intermediates and of curcumin itself. In addition, knockout of curcumin reductase (curA) 45 and staged pH control increased the curcumin titer in shake flasks and a pilot scale. The addition of methionine ensured a sufficient methyl supply, which increases the supply of ferulic acid in the later stage of fermentation and further improved the production of curcumin.…”
Section: Discussionmentioning
confidence: 99%
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“…In summary, the highest curcumin titer was achieved by increasing the copy number of biosynthetic modules to balance metabolic flow and the fusion of DCS and CURS1, eliminating repression of the β-oxidation pathway, suppressing the consumption of malonyl-CoA by E. coli, and expressing the srpB efflux pump to alleviate the toxicity of biosynthetic pathway intermediates and of curcumin itself. In addition, knockout of curcumin reductase (curA) 45 and staged pH control increased the curcumin titer in shake flasks and a pilot scale. The addition of methionine ensured a sufficient methyl supply, which increases the supply of ferulic acid in the later stage of fermentation and further improved the production of curcumin.…”
Section: Discussionmentioning
confidence: 99%
“…coli, and expressing the srpB efflux pump to alleviate the toxicity of biosynthetic pathway intermediates and of curcumin itself. In addition, knockout of curcumin reductase ( curA ) and staged pH control increased the curcumin titer in shake flasks and a pilot scale. The addition of methionine ensured a sufficient methyl supply, which increases the supply of ferulic acid in the later stage of fermentation and further improved the production of curcumin.…”
Section: Discussionmentioning
confidence: 99%
“…In vivo applications of curcumin-containing compositions are subjected to enzymatic degradation, leading to different dehydrocurcumin derivatives [118,119]. The impact of a fully conjugated system on the antiradical activity of curcumin is analyzed here below.…”
Section: Curcumin and Its Derivativesmentioning
confidence: 99%
“…The impact of a fully conjugated system on the antiradical activity of curcumin is analyzed here below. It should be noted that tetrahydrocurcumin, due to its lower autooxidation, exhibits better antioxidant properties in comparison to curcumin [119].…”
Section: Curcumin and Its Derivativesmentioning
confidence: 99%
“…Although, THC has better stability than curcumin in physiological condition (Zhu et al., 2023 ), its therapeutic applications are limited by its low aqueous solubility, which is a key process for bioaccessibility (Pandey et al., 2020 ; Loron et al., 2021 ; Jongjitphisut et al., 2023 ). Several researchers developed various systems to increase THC aqueous solubility, such as solid lipid nanoparticles (Saini et al., 2022 ), nanostructured lipid carriers (Truong et al., 2022 ), nanoemulsions (Tang et al., 2021 ), nanofiber (Ravikumar et al., 2018 ), polymer drug conjugate (Tang et al., 2021 ) and inclusion complexes (Loron et al., 2021 ).…”
Section: Introductionmentioning
confidence: 99%