Tetrahydroanthracene Derivative: Anti-microbial Isolate  from Acanthospermum hispidum DC

Olawumi, Olajide Olutayo; Ibrahim, Oladosu; Christianah, Fakunle

doi:10.14419/ijac.v2i2.3519

Cited by 4 publications

(3 citation statements)

References 1 publication

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“…The results of the antimicrobial test on the isolated compound show activity against P. mirabilis, B. subtilis, P. aeruginosa, C. albican, S. typhi and B. cereus at minimum inhibitory concentration (MIC) value of 100 ppm Olajide et al, (2014). Early workers have reported the use of the stem bark for medicinal purposes (Chakraborty et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and in-Vitro Antimicrobial Activities of the Leaf Extract of Acanthospermum hispidum DC (Asteraceae)

A¹,

Sodipo²,

Khan³

et al. 2015

JPS

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The study into the chemical contents and in-vitro antimicrobial activities of the methanolic leaf extract of Acanthospermum hispidum were carried out. The extract was evaluated for its antibacterial activity against four Gram positive (Staphylococcus aureus, Streptococcus pyogenes, Corynebacteria specie and Bacillus subtilis) and four Gram negative bacteria (Salmonella typhi, Klebsiella phumoniae, Pseudomonas aeruginosa and Escherichia coli). The fungal strains used were Aspergilus niger, Penicillium sp. and Candida albicans. The sensitive microorganisms (Conynebacteria sp., Pseudomonas aeragunosa, Klebsiella pneumoniae, Bacillus subtilis and Staphylococcus aureus) had zones of inhibition ranging from 12.20 ± 1.06 mm to 24.00 ± 1.00 mm at 100 mg/ml, while the standard drug (tetracycline 250 mg) had zones of inhibition in the range 20.27 ± 0.64 mm to 27.23 ± 0.68 mm against all the microorganisms tested in this study. The MIC/MBC against the tested organisms ranged from 25 mg/ml to 50 mg/ml and 50 mg/ml to 100 mg/ ml respectively. The results obtained from this study revealed that the leaf extract of Acanthospermum hispidum possesses antibacterial activity against some pathogenic microorganisms tested. The study confirmed the use of the leaf of Acanthospermum hispidum in some parts of Northern Nigeria as a remedy against diarrhoea, dysentery and other related diseases. In view of the reported uses of this plant, the present study investigated the antimicrobial effect of the methanol extract of A. hispidum on some Gram positive, Gram negative and some fungal species. Therefore, this study validates the medicinal use of Acanthospermum hispidum tradicinally in some parts of Northern Nigeria.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and in-Vitro Antimicrobial Activities of the Leaf Extract of Acanthospermum hispidum DC (Asteraceae)

A¹,

Sodipo²,

Khan³

et al. 2015

JPS

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“…Some studies describe the chemical composition of the leaves or aerial parts of A. hispidum , showing mainly the presence of compounds from the flavonoid class, such as quercetin derivatives, cinnamic acids, such as chlorogenic acid derivatives and dicafeioilquinic acid derivatives, and terpenoids [19–22] . The presence of tannins, alkaloids, saponins, cardioactive glycosides, and anthraquinones has also been reported [23–26] . Corroborating what is described in the scientific literature, the phytochemical analysis performed on the crude extract and fractions of A. hispidum aerial parts revealed the presence of phenolic compounds, with hydroxycinnamic derivatives standing out.…”

Section: Resultsmentioning

confidence: 99%

“…[19][20][21][22] The presence of tannins, alkaloids, saponins, cardioactive glycosides, and anthraquinones has also been reported. [23][24][25][26] Corroborating what is described in the scientific literature, the phytochemical analysis performed on the crude extract and fractions of A. hispidum aerial parts revealed the presence of phenolic compounds, with hydroxycinnamic derivatives standing out. The chromatogram obtained by TLC can be seen in Figure 2.…”

Section: Characterization Of Crude Extract and Fractionsmentioning

confidence: 95%

Evaluation of the Antioxidant and Antifungal Actions of the Optimized Crude Extract and Fractions from the Aerial Parts of Acanthospermum hispidum

Santos

Silva

Machado

et al. 2022

Chemistry & Biodiversity

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This study investigated the phytochemical characteristics of the aerial parts of Acanthospermum hispidum, by chromatographic and spectrophotometric methods, and evaluated the antioxidant and antifungal activities of the crude extract and polyphenol‐enriched fractions of the species. The phytochemical prospection showed the presence of polyphenols from the groups of hydroxycinnamic derivatives and flavonoids in the crude extract (CE) and fractions of the aerial parts of A. hispidum. In the chromatographic analysis, it was possible to observe that the fractionation process of the CE with hexane and ethyl acetate was efficient in enriching the fractions in phenolic compounds. This enrichment provided an increase in antioxidant activity by the DPPH and ABTS methods, in which it was observed a higher antioxidant activity for EAF in the DPPH test and higher activity against the ABTS radical by the fractions AqF and RAqF. The extract and fractions were effective against Candida non‐Candida albicans strains, mainly against C. glabrata, C. parapsilosis and C. krusei, acting predominantly fungicidal. The results indicate that the aerial parts of A. hispidum can serve as a basis for the development of new antioxidant and antifungal products. Moreover, the fractionation process can contribute to increasing the biological potential of the species.

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Bio-guided isolation and bioinformatic studies of cytotoxic phytosterols from Acanthospermum hispidum DC against breast (MCF7) and colorectal (HT29) cancer cells

Alnoor,

Abdalla,

Abdel Bar

et al. 2024

Arab Journal of Basic and Applied Sciences

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Tetrahydroanthracene Derivative: Anti-microbial Isolate from Acanthospermum hispidum DC

Cited by 4 publications

References 1 publication

Phytochemical Screening and in-Vitro Antimicrobial Activities of the Leaf Extract of Acanthospermum hispidum DC (Asteraceae)

Phytochemical Screening and in-Vitro Antimicrobial Activities of the Leaf Extract of Acanthospermum hispidum DC (Asteraceae)

Evaluation of the Antioxidant and Antifungal Actions of the Optimized Crude Extract and Fractions from the Aerial Parts of Acanthospermum hispidum

Bio-guided isolation and bioinformatic studies of cytotoxic phytosterols from Acanthospermum hispidum DC against breast (MCF7) and colorectal (HT29) cancer cells

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