Tetrahydro-6-methyl-1H,3H-thieno[3,4-b]pyrrol-2-one, an Analogue of Biotin

Abstract

The title compound, C7HIINOS, an analogue of biotin, was prepared in order to further investigate the binding characteristics of biotin. The bicyclic ring system has pseudo-mirror symmetry with the tetrahydrothieno ring in an S5fl-envelope form with the methyl substituent in an equatorial position. The cis-fused pyrrolidone system is planar [non-H atoms coplanar within 0.03 (1)A] and the dihedral angle between it and the four coplanar C atoms of the tetrahydrothieno ring is 119.0(2) °. The C--S bond lengths are 1.808 (4) and 1.803 (4),~, and the C--S---C angle is 88.8 (2) °. CommentThe structure determination of tetrahydro-6-methyl-