Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus <i>via</i> the PI3K/Akt Pathway

Li, Yanjing; Tang, Yu; Shi, Sirong; Gao, Shaojingya; Wang, Yun; Xiao, Dexuan; Chen, Tianyu; He, Qing; Zhang, Junjiang; Lin, Yunfeng

doi:10.1021/acsami.1c11468

Cited by 32 publications

(22 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetes mellitus (DM) is a disease caused by lack of insulin secretion or insulin resistance, which cause the body to experience persistent hyperglycemia and long-term metabolic disorders. DM is classified into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), in which T2DM accounts for nearly 95% of individuals, and the number of patients is increasing year by year [1,2]. Insulin resistance (IR) is one of the essential conditions in the development of type 2 diabetes mellitus, and insulin reduces blood sugar levels and improves IR by promoting glucose absorption [3].…”

Section: Introductionmentioning

confidence: 99%

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Liu

Zhou²,

Zhang³

et al. 2021

Molecules

View full text Add to dashboard Cite

Gymnema sylvestre (Retz.) Schult is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of G. sylvestre, a chemical investigation was thus performed. In this research, four new C21 steroidal glycosides sylvepregosides A-D (1–4) were isolated along with four known compounds, gymnepregoside H (5), deacetylkidjoladinin (6), gymnepregoside G (7) and gymnepregoside I (8), from the ethyl acetate fraction of G. sylvestre. The structures of the new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. Compounds 1–6 promoted glucose uptake by the range of 1.10- to 2.37-fold, respectively. Compound 1 showed the most potent glucose uptake, with 1.37-fold enhancement. Further study showed that compounds 1 and 5 could promote GLUT-4 fusion with the plasma membrane in L6 cells. The result attained in this study indicated that the separation and characterization of these compounds play an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry.

show abstract

Section: Introductionmentioning

confidence: 99%

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Liu

Zhou²,

Zhang³

et al. 2021

Molecules

View full text Add to dashboard Cite

show abstract

“…Furthermore, researchers have found that suppression of the PI3K/Akt signaling pathway is implicated in high-glucose-induced cell dysfunction [ 33 ]. As shown in Figure 1 , insulin activates and binds to the insulin receptor (InsR), inducing PI3K-AKT activation.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice

Zhai

Zhu

et al. 2022

Antioxidants

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is associated with an oxidative milieu that often leads to adverse health problems. Bioactive peptides of zein possess outstanding antioxidant activity; however, their effects on hyperglycemia-related oxidative stress remain elusive. In the present study, the dipeptide Tyr-Ala (YA), a functional peptide with typical health benefits, was applied to alleviate oxidative stress in pancreatic islets under hyperglycemic conditions. By detecting viability, antioxidant ability, and insulin secretion in INS-1 cells, YA showed excellent protection of INS-1 cells from H2O2 oxidative stress, erasing reactive oxygen species (ROS) and promoting insulin secretion. Moreover, by Western blotting, we found that YA can regulate the PI3K/Akt signaling pathway associated with glycometabolism. After establishing a T2DM mice model, we treated mice with YA and measured glucose, insulin, hemoglobin A1C (HbA1c), total cholesterol (TC), triglyceride (TG), and malonaldehyde (MDA) levels and activities of superoxide dismutase (SOD) and glutathione (GSH) from blood samples. We observed that YA could reduce the production of glucose, insulin, HbA1c, TC, TG, and MDA, in addition to enhancing the activities of SOD and GSH. YA could also repair the function of the kidneys and pancreas of T2DM mice. Along with the decline in fasting blood glucose, the oxidative stress in islets was alleviated in T2DM mice after YA administration. This may improve the health situation of diabetic patients in the future.

show abstract

“…DNA nanomaterials with distinctive spatial configurations are known as tetrahedral framework nucleic acids (TFNAs) (69). TFNAs have excellent biosafety with anti-inflammatory, antioxidant, anti-fibrotic, angiogenic, and skin wound healing activities with little toxicity (70).…”

Section: Role Of Pyroptosis and Inflammasomes In Wound Healingmentioning

confidence: 99%

Pyroptosis and inflammasomes in diabetic wound healing

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

Diabetic wound is one of the complications of diabetes and is not easy to heal. It often evolves into chronic ulcers, and severe patients will face amputation. Compared with normal wounds, diabetic wounds have an increased proportion of pro-inflammatory cytokines that are detrimental to the normal healing response. The burden of this disease on patients and healthcare providers is overwhelming, and practical solutions for managing and treating diabetic wounds are urgently needed. Pyroptosis, an inflammatory type of programmed cell death, is usually triggered by the inflammasome. The pyroptosis-driven cell death process is primarily mediated by the traditional signaling pathway caused by caspase -1 and the non-classical signaling pathways induced by caspase -4/5/11. Growing evidence that pyroptosis promotes diabetic complications, including diabetic wounds. In addition, inflammation is thought to be detrimental to wound healing. It is worth noting that the activation of the NLRP3 inflammasome plays a crucial role in the recovery of diabetic wounds. This review has described the mechanisms of pyroptosis-related signaling pathways and their impact on diabetic wounds. It has discussed new theories and approaches to promote diabetic wound healing, as well as some potential compounds targeting pyroptosis and inflammasome signaling pathways that could be new approaches to treating diabetic wounds.

show abstract

Tetrahedral Framework Nucleic Acids Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus via the PI3K/Akt Pathway

Cited by 32 publications

References 66 publications

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Antioxidant Effect of Tyr-Ala Extracted from Zein on INS-1 Cells and Type 2 Diabetes High-Fat-Diet-Induced Mice

Pyroptosis and inflammasomes in diabetic wound healing

Contact Info

Product

Resources

About