Tetrahedral Framework Nucleic Acid‐Based Delivery of Astaxanthin Suppresses Chondrocyte Pyroptosis and Modulates Oxidative Stress for the Treatment of Osteoarthritis
Yifan Li,
Jiafeng Li,
Sheng Xu
et al.
Abstract:Worldwide, osteoarthritis (OA) is regarded as the most widespread, distressing, and limiting chronic disease affecting degenerative joints, and there is currently no disease‐modifying treatment for OA. The pathogenesis of OA is significantly linked with oxidative stress and the process of pyroptosis. Astaxanthin (Ast) is a natural keto‐carotenoid pigment with potent antioxidant activity and has been shown to effectively alleviate cartilage damage in OA. However, its poor water solubility and high sensitivity t… Show more
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