Tetrahedral Framework Nuclear Acids Can Regulate Interleukin-17 Pathway to Alleviate Inflammation and Inhibit Heterotopic Ossification in Ankylosing Spondylitis

Wang, Lihang; Wang, Yun; Jiang, Yang; Chen, Ming; Li, Zhuhai; Wang, Kai; Luo, Chunshan; Ning, Ning; Zeng, Jiancheng; Zhou, Zongke; Song, Yueming; Yang, Fan; Huang, Shi-shu; Lin, Yunfeng

doi:10.1021/acsnano.3c09480

Cited by 7 publications

(1 citation statement)

References 42 publications

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“…Recently, tetrahedral framework nucleic acids (tFNAs), a type of nanomaterials composed of four prearranged single‐stranded DNAs, have recently demonstrated significant promise in the biomedical domain due to their favourable biocompatibility, exceptional cellular uptake, and unparalleled programming. 16 , 17 , 18 , 19 , 20 Tian et al proved that tFNAs can have the ability to penetrate cells via caveolin‐mediated endocytosis, subsequently impacting diverse biological processes in receptor cells. 21 Research has indicated that tFNAs not just stimulate cell growth, movement, and specialisation but also have a significant function in regulating inflammation.…”

Section: Introductionmentioning

confidence: 99%

Effect of tetrahedral framework nucleic acids on the reconstruction of tendon‐to‐bone injuries after rotator cuff tears

Li,

Fu,

Ning

et al. 2024

Cell Proliferation

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Clinicians and researchers have always faced challenges in performing surgery for rotator cuff tears (RCT) due to the intricate nature of the tendon‐bone gradient and the limited long‐term effectiveness. At the same time, the occurrence of an inflammatory microenvironment further aggravates tissue damage, which has a negative impact on the regeneration process of mesenchymal stem cells (MSCs) and eventually leads to the production of scar tissue. Tetrahedral framework nucleic acids (tFNAs), novel nanomaterials, have shown great potential in biomedicine due to their strong biocompatibility, excellent cellular internalisation ability, and unparalleled programmability. The objective of this research was to examine if tFNAs have a positive effect on regeneration after RCTs. Experiments conducted in a controlled environment demonstrated that tFNAs hindered the assembly of inflammasomes in macrophages, resulting in a decrease in the release of inflammatory factors. Next, tFNAs were shown to exert a protective effect on the osteogenic and chondrogenic differentiation of bone marrow MSCs under inflammatory conditions. The in vitro results also demonstrated the regulatory effect of tFNAs on tendon‐related protein expression levels in tenocytes after inflammatory stimulation. Finally, intra‐articular injection of tFNAs into a rat RCT model showed that tFNAs improved tendon‐to‐bone healing, suggesting that tFNAs may be promising tendon‐to‐bone protective agents for the treatment of RCTs.

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Section: Introductionmentioning

confidence: 99%

Effect of tetrahedral framework nucleic acids on the reconstruction of tendon‐to‐bone injuries after rotator cuff tears

Li,

Fu,

Ning

et al. 2024

Cell Proliferation

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In Vivo Interactions of Nucleic Acid Nanostructures With Cells

Xiao,

Liang,

Shyngys

et al. 2024

Advanced Materials

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Nucleic acid nanostructures, derived from the assembly of nucleic acid building blocks (e.g., plasmids and oligonucleotides), are important intracellular carriers of therapeutic cargoes widely utilized in preclinical nanomedicine applications, yet their clinical translation remains scarce. In the era of “translational nucleic acid nanotechnology”, a deeper mechanistic understanding of the interactions of nucleic acid nanostructures with cells in vivo will guide the development of more efficacious nanomedicines. This review showcases the recent progress in dissecting the in vivo interactions of four key types of nucleic acid nanostructures (i.e., tile‐based, origami, spherical nucleic acid, and nucleic acid nanogel) with cells in rodents over the past five years. Emphasis lies on the cellular‐level distribution of nucleic acid nanostructures in various organs and tissues and the cellular responses induced by their cellular entry. Next, in the spirit of preclinical translation, this review features the latest interactions of nucleic acid nanostructures with cells in large animals and humans. Finally, the review offers directions for studying the interactions of nucleic acid nanostructures with cells from both materials and biology perspectives and concludes with some regulatory updates.

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Research advances of tetrahedral framework nucleic acid-based systems in biomedicine

Wang,

Javier,

Luo

et al. 2024

Chinese Chemical Letters

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Tetrahedral Framework Nuclear Acids Can Regulate Interleukin-17 Pathway to Alleviate Inflammation and Inhibit Heterotopic Ossification in Ankylosing Spondylitis

Cited by 7 publications

References 42 publications

Effect of tetrahedral framework nucleic acids on the reconstruction of tendon‐to‐bone injuries after rotator cuff tears

Effect of tetrahedral framework nucleic acids on the reconstruction of tendon‐to‐bone injuries after rotator cuff tears

In Vivo Interactions of Nucleic Acid Nanostructures With Cells

Research advances of tetrahedral framework nucleic acid-based systems in biomedicine

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