Tetrahedral DNA frameworks for biosensing and imaging analysis in living cells

Qi, Zhijie; Wei, Chen; Zhang, Fei; Wang, Zejun; Zuo, Xiaolei

doi:10.1016/j.nantod.2023.102127

Nano Today

2024

DOI: 10.1016/j.nantod.2023.102127

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Tetrahedral DNA frameworks for biosensing and imaging analysis in living cells

Zhijie Qi,

Chen Wei,

Fei Zhang

et al.

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2024

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Cited by 6 publications

References 159 publications

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High‐Density Arrangement of Biomimetic Plasmonic Nanoprobes Guided by DNA Nanoroller based Cleaving‐Rolling Process for SERS Sensing Analysis

Xu,

Li,

Liu

et al. 2024

Adv Funct Materials

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DNA walker nanomachines are in fast development for biosensing, medical diagnostics, and food safety monitoring. For practical application, the issues of slow dynamics and low operational efficiency hinder its widespread application. Inspired by the high efficiency of agricultural cooperative machinery, a unique cleaving‐rolling‐assembly integrated nanodevice (CRAIN) is constructed for the high‐performance detection of various biomolecules. In the design, DNA nanotubes are introduced as building loaders to engineer polyoriented walking DNA nanorollers with blocked DNAzyme‐based walking strands and thus to increase the reaction direction and local concentration. Through target‐specific recognition, the activated nanorollers can autonomously and progressively cleave and roll along directional hairpin tracks on a gold substrate, significantly accelerating the reaction rate. Moreover, using nucleic acid‐encoded urchin‐shaped multispike gold‐silver composite nanospheres (nMGSs) as SERS‐enhanced probes, the engineered assembly of nMGSs probes induced by the cleaving‐rolling process promotes the formation of high‐density hotspot domains, further improving the detection sensitivity. With rational design, the CRAIN system can be extended to perform highly sensitive analyses of various analytes, such as microRNA‐21, butyrylcholinesterase activity and organophosphorus pesticides. This integrated assembly strategy can provide new perspectives for clinical diagnosis, biomedical engineering, and environmental science.

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High‐Density Arrangement of Biomimetic Plasmonic Nanoprobes Guided by DNA Nanoroller based Cleaving‐Rolling Process for SERS Sensing Analysis

Xu,

Li,

Liu

et al. 2024

Adv Funct Materials

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Both intrinsic and microenvironmental factors contribute to the regulation of stem cell quiescence

Zhou,

Hu,

et al. 2024

Journal Cellular Physiology

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Precise regulation of stem cell quiescence is essential for tissue development and homeostasis. Therefore, its aberrant regulation is intimately correlated with various human diseases. However, the detailed mechanisms of stem cell quiescence and its specific role in the pathogenesis of various diseases remain to be determined. Recent studies have revealed that the intrinsic and microenvironmental factors are the potential candidates responsible for the orderly switch between the dormant and activated states of stem cells. In addition, defects in signaling pathways related to internal and external factors of stem cells might contribute to the initiation and development of diseases by altering the dormancy of stem cells. In this review, we focus on the mechanisms underlying stem cell quiescence, especially the involvement of intrinsic and microenvironmental factors. In addition, we discuss the relationship between the anomalies of stem cell quiescence and related diseases, hopefully providing therapeutic insights for developing novel treatments.

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A bivariate fluorescence biosensor based on Janus DNA nanoarchitecture-loaded dual-emissive Ag nanoclusters as bi-responsive signaling reporters

Yang,

Shi,

Zhang

et al. 2024

Biosensors and Bioelectronics

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Tetrahedral DNA frameworks for biosensing and imaging analysis in living cells

Cited by 6 publications

References 159 publications

High‐Density Arrangement of Biomimetic Plasmonic Nanoprobes Guided by DNA Nanoroller based Cleaving‐Rolling Process for SERS Sensing Analysis

High‐Density Arrangement of Biomimetic Plasmonic Nanoprobes Guided by DNA Nanoroller based Cleaving‐Rolling Process for SERS Sensing Analysis

Both intrinsic and microenvironmental factors contribute to the regulation of stem cell quiescence

A bivariate fluorescence biosensor based on Janus DNA nanoarchitecture-loaded dual-emissive Ag nanoclusters as bi-responsive signaling reporters

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