“…10,11 As a multifunctional nanomaterial, gold nanoparticles (AuNPs) have been widely used as active substrates in SERS sensors based on their "hot spot" effect, [12][13][14][15] and the distance between the signal molecules and the surface of the AuNPs controls the enhancement/reduction of the SERS signal. 16,17 On the other hand, when the signal molecules are sufficiently close to the surface of the AuNPs (<5 nm), their fluorescence (FL) will be significantly quenched thanks to the nonradiative decay through energy and/or charge transfer to the AuNPs. [18][19][20] The unique optical and electrical properties of AuNPs provide feasibility for constructing sensors with integrated SERS and FL dual signal responses, which is of great significance for improving the anti-interference ability of sensing systems.…”