Tetracycline treatment and sex-ratio distortion: a role for Wolbachia in the moulting of filarial nematodes?

Casiraghi, Maurizio; McCall, John W.; Simoncini, Lavinia; Kramer, Laura; Sacchi, Luciano; Genchi, C.; Werren, John H.; Bandi, Claudio

doi:10.1016/s0020-7519(02)00158-3

Cited by 86 publications

(60 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Point (b) opens interesting perspectives: if W. pipientis infection can really be lost during evolution, how stable is the association between these bacteria and their nematode hosts? Is it possible that the close relationship between W. pipientis and its nematode hosts shown in some recent papers (see Casiraghi et al, 2002) could be broken? Does the association between W. pipientis and the nematode host have the same 'strength' in all filarial species?…”

Section: Discussionmentioning

confidence: 99%

“…In arthropods W. pipientis generally induces alterations in host reproduction (Werren, 1997;Stouthamer et al, 1999 andBandi et al, 2001). In filarial nematodes there is convincing evidence that these bacteria are required for the development and reproduction of their hosts Bandi et al, 1999;Hoerauf et al, 1999;McCall et al, 1999;Hoerauf et al, 2000 andCasiraghi et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution

Casiraghi

Bain

Guerrero

et al. 2004

International Journal for Parasitology

238

223

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution

Casiraghi

Bain

Guerrero

et al. 2004

International Journal for Parasitology

238

223

View full text Add to dashboard Cite

“…In nematodes, Wolbachia is an obligate symbiont, as worms depend on bacteria for survival. Antibiotic curing of Wolbachia "infection" inhibits nematode fertility and development, suggesting a specific role for the symbiont in host oogenesis, embryogenesis and moulting (Arumugam et al, 2008;Casiraghi et al, 2002;Frank et al, 2010). In arthropods the bacterium is able to manipulate the host reproduction in order to increase the number of infected females.…”

Section: Ecdysteroids and Wolbachia: Different Roles And Different Mamentioning

confidence: 99%

Sex Steroids in Insects and the Role of the Endosymbiont Wolbachia:A New Perspective

Negri¹,

Pellecchia²

2012

Sex Hormones

View full text Add to dashboard Cite

“…Previous studies have shown that TET will eradicate Wolbachia from B. pahangi in vivo and in vitro (4,47). In addition, TET treatment has also been shown to interrupt embryogenesis in many filariae (4,10,18,19). B. pahangiϩTET gerbils, then, carried B. pahangi infections that were Wolbachia negative and amicrofilaremic.…”

mentioning

confidence: 99%

Removal of Wolbachia from Brugia pahangi Is Closely Linked to Worm Death and Fecundity but Does Not Result in Altered Lymphatic Lesion Formation in Mongolian Gerbils ( Meriones unguiculatus )

Chirgwin¹,

Coleman²,

Porthouse³

et al. 2003

Infect Immun

View full text Add to dashboard Cite

Approximately 30 years ago, researchers reported intracellular bacteria in filarial nematodes. These bacteria are relatives of the arthropod symbiont Wolbachia and occur in many filarial nematodes, including Brugia pahangi and Brugia malayi. Wolbachia bacteria have been implicated in a variety of roles, including filaria development and fecundity and the pathogenesis of lymphatic lesions associated with filarial infections. However, the role of the bacteria in worm biology or filarial disease is still not clear. The present experiments support previous data showing that tetracycline eliminates or reduces Wolbachia bacteria in B. pahangi in vivo. The elimination of Wolbachia was closely linked to a reduction in female fecundity and the viability of both sexes, suggesting that the killing of Wolbachia is detrimental to B. pahangi. The gerbils treated with tetracycline showed reduced levels of interleukin-4 (IL-4) and IL-5 mRNA in renal lymph nodes and spleens compared with the levels in B. pahangi-infected gerbils not treated with tetracycline. However, similar findings were noted in B. pahangi-infected gerbils treated with ivermectin, suggesting that the loss of circulating microfilariae, not the reduction of Wolbachia bacteria, was associated with the altered cytokine profile. Despite the change in T-cell cytokines, there was no difference in the sizes of renal lymph nodes isolated from gerbils in each treatment group. Furthermore, the numbers, sizes, or cellular compositions of granulomas examined in the lymphatics or renal lymph nodes did not differ with treatment. These data suggest that Wolbachia may not play a primary role in the formation of lymphatic lesions in gerbils chronically infected with B. pahangi.Lymphatic filariasis is caused primarily by the filarial nematodes Wuchereria bancrofti and Brugia malayi and affects more than 120 million people throughout the tropics and subtropics. The disease presents as a broad range of clinical and subclinical symptoms, including fever, acute and chronic inflammation, lymphatic edema, and elephantiasis. While much research has focused on the disease caused by infection with Brugia or Wuchereria, the mechanism(s) underlying the pathogenesis of lymphatic filariasis has not been clearly defined. In both acute and chronic infections, these mechanisms probably involve a diverse range of inflammatory reactions attributable to the parasite, host inflammatory responses, and opportunistic infections (40).Approximately 30 years ago, several researchers reported intracellular bacteria in filarial nematodes (31, 37, 54). These bacteria have since been identified as relatives of the arthropod symbiont Wolbachia (46). Wolbachia bacteria have now been reported to exist in many filarial nematodes, including B. malayi and Brugia pahangi (3,30,49,55). Interestingly, Wolbachia has recently been proposed to play a role in the induction of the host immune response to filariae (9,44,50,51). Some researchers suggest that lipopolysaccharide (LPS)-like molecules from filarial Wolbachia b...

show abstract

Tetracycline treatment and sex-ratio distortion: a role for Wolbachia in the moulting of filarial nematodes?

Cited by 86 publications

References 22 publications

Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution

Mapping the presence of Wolbachia pipientis on the phylogeny of filarial nematodes: evidence for symbiont loss during evolution

Sex Steroids in Insects and the Role of the Endosymbiont Wolbachia:A New Perspective

Removal of Wolbachia from Brugia pahangi Is Closely Linked to Worm Death and Fecundity but Does Not Result in Altered Lymphatic Lesion Formation in Mongolian Gerbils ( Meriones unguiculatus )

Contact Info

Product

Resources

About