Tetracycline sclerotherapy for the treatment of recurrent pooling of plasma in the submandibular tissue space: case report

Injection Snoreplasty: Investigation of Alternative Sclerotherapy Agents

“…Review of the literature resulted in the consideration of 3 agents that met these criteria: ethanol (99%, injectable dehydrated alcohol), doxycycline (10 mg/mL solution injectable), and hypertonic (23.6%) saline. Each is indeed readily available and inexpensive and has been reported for the treatment of various lesions in the head and neck to include lymphangiomas, thyroid and parathyroid cysts, and benign glomus tumors with excellent documented safety and efficacy 10-16 . Each agent's efficacy and safety as a palatal sclerosing agent were first evaluated using a described canine palatal flutter model 17 .…”

“…Each is indeed readily available and inexpensive and has been reported for the treatment of various lesions in the head and neck to include lymphangiomas, thyroid and parathyroid cysts, and benign glomus tumors with excellent documented safety and efficacy. [10][11][12][13][14][15][16] Each agent's efficacy and safety as a palatal sclerosing agent were first evaluated using a described canine palatal flutter model. 17 Those that were found to be comparable to 3% STS were then used in a prospective human pilot study in which snoring efficacy was subjectively and objectively measured.…”

Sclerotic Effect of Oxytetracycline on the Submandibular Gland: An Experimental Model

“…It is preferred for sclerotherapy in numerous pathologies, including malignant pleural effusions, renal cysts, and lymphatic malformations of the head and neck. 1–3 Some authors have suggested that the sclerotic action of oxytetracycline is triggered by its extremely low pH level. 4 However, Keller contended that its sclerotic effects are attributable to more than low pH.…”