Tetracycline-Resistant Pneumococci

Richards, James; Rycroft, Julian Anthony

doi:10.1016/s0140-6736(63)91351-5

Cited by 18 publications

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“…The isolate (MIC, 11 mg/liter) was from the CSF of a 10-month-old child. The same year, tetracycline-resistant pneumococci were isolated from the sputa of four elderly patients with chronic bronchitis in the United Kingdom (222) and an outbreak of tetracycline-resistant pneumococci was detected in two general wards in Liverpool, United Kingdom (264). Five of the ten patients had received tetracycline prior to the isolation of the resistant strain, all failed to respond to tetracycline or relapsed after initial improvement, and one had a profuse growth of tetracycline-resistant pneumococci in the sputum 4 months after discharge from hospital (264).…”

Section: Note On Nomenclature and Criteria Of Resistancementioning

confidence: 99%

Pneumococcal resistance to antibiotics

1990

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The geographic distribution of pneumococci resistant to one or more of the antibiotics penicillin, erythromycin, trimethoprim-sulfamethoxazole, and tetracycline appears to be expanding, and there exist foci of resistance to chloramphenicol and rifampin. Multiply resistant pneumococci are being encountered more commonly and are more often community acquired. Factors associated with infection caused by resistant pneumococci include young age, duration of hospitalization, infection with a pneumococcus of serogroup 6, 19, or 23 or serotype 14, and exposure to antibiotics to which the strain is resistant. At present, the most useful drugs for the management of resistant pneumococcal infections are cefotaxime, ceftriaxone, vancomycin, and rifampin. If the strains are susceptible, chloramphenicol may be useful as an alternative, less expensive agent. Appropriate interventions for the control of resistant pneumococcal outbreaks include investigation of the prevalence of resistant strains, isolation of patients, possible treatment of carriers, and reduction of usage of antibiotics to which the strain is resistant. The molecular mechanisms of penicillin resistance are related to the structure and function of penicillin-binding proteins, and the mechanisms of resistance to other agents involved in multiple resistance are being elucidated. Recognition is increasing of the standard screening procedure for penicillin resistance, using a 1-microgram oxacillin disk.

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Section: Note On Nomenclature and Criteria Of Resistancementioning

confidence: 99%

Pneumococcal resistance to antibiotics

1990

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“…The generally positive response of pneumococcal infections to penicillin treatment in the past and the exquisite susceptibility of pneumococci to penicillins in vitro seem to negate the possibility that penicillin-resistant pneumococci may appear in human disease (3, 6, 8, 9, 11). On the other hand, tetracycline-resistant pneumococci have been found in pneumonias (4,13,14), and, recently, erythromycin-resistant pneumococci were also detected (7). In 1967, Hansman (5) isolated typical pneumococci which were relatively resistant to penicillin from a patient with bronchiectasis.…”

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confidence: 99%

Penicillin-resistant Variants of Pneumococci

Gunnison¹,

Fraher²,

Pelcher³

et al. 1968

Applied Microbiology

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All of the 74 strains of pneumococci isolated from human infections from 1963 to 1964 proved to be uniformly and highly susceptible to penicillin. Of these strains, 15 were identified by capsule-swelling reactions and were submitted to serial transfer in the presence of increasing concentrations of penicillin. Highly penicillinresistant mutants were selected from 14 of the 15 strains, whereas one strain was moderately resistant. Of these mutants, 11 could still react with specific antiserum, and all of the mutants could be identified by fermentation reactions and optochin inhibition. The in vitro development of penicillin resistance in these mutants did not result in a change in cell-wall composition sufficient to diminish bile solubility. The possibility of encountering rising penicillin resistance among pneumococci, as well as the possibility that such mutants may react atypically, should be kept in mind.

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“…From the study of the results of several workers (Evans and Hansmans 1963, Richards and Rycroft 1963, Turner and Leeds 1963, Dixon 1967, Appelbaum et al 1977, Zackrisson and Bronson 1981, Howard et al 1978, Jacobs et al 1978) and from the results of this work it can be concluded that : 1) most Str. pneumoniae strains are still sensitive to commonly used antibiotics, like penicillin, ampicillin, erythromycin, tetracyclin, chloramphenicol, trimethoprime -sulfamethoxazole, tobramycin and amikacin.…”

Section: S U M M a R Ymentioning

confidence: 71%

Συγκριτικη Μελετη Θρεπτικων Υλικων Για Την Απομονωση Του Πνευμονιοκοκκου Και Ελεγχος Της Αντοχης Στελεχων Πνευμονιοκοκκου Στα Αντιβιοτικα

Σαγγανα¹

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μουν σάν αγροτικός γιατρός στό αγροτικό ιατρείο Κυλλήνης του Νομού Ηλείας. Τόν 'Ιούλη του 1973 εως καί τόν 'Οκτώβρη του 1976 έκανα ειδικότητα Μικροβιολογίας στό Διαγνωστικό καί Θεραπευτικό 'Ινστιτούτο Μεταξά στό Πειραιά. Τίτλο ειδικότητας Μικροβιολόγου απόκτησα μετά άπό εξετάσεις τόν 'Οκτώβρη του 1976. Άπό τήν 1η του Γενάρη του 1976 μέχρι και τήν 1η Μάη του ϊδιου χρό νου παρακολούθησα ραδιοανοσοβιολογία στό εργαστήριο της Πυρηνικής 'Ιατρικής του ϊδιου Νοσοκομείου. 'Από τίς 4 'Απρίλη του 1977 μέχρι καί σήμερα εργάζομαι σάν ειδικευ μένη έμμισθη βοηθός στό Μικροβιολογικό 'Εργαστήριο του Ιπποκράτειου Νοσοκομείου 'Αθηνών. Αυτή ή διατριβή έγινε στό Μικροβιολογικό καί βιοχημικό εργαστήριο του Ι.Γ.Ν.Α. πού διευθύνει ό Υφηγητής κ. Ι. Λεοναρδόπουλος.

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Tetracycline-Resistant Pneumococci

Cited by 18 publications

References 0 publications

Pneumococcal resistance to antibiotics

Pneumococcal resistance to antibiotics

Penicillin-resistant Variants of Pneumococci

Συγκριτικη Μελετη Θρεπτικων Υλικων Για Την Απομονωση Του Πνευμονιοκοκκου Και Ελεγχος Της Αντοχης Στελεχων Πνευμονιοκοκκου Στα Αντιβιοτικα

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