Tetracycline in nongonococcal urethritis. Comparison of 2 g and 1 g daily for seven days.

Bowie, W R; Yu, John S.; Fawcett, A.; Jones, Hugh D.

doi:10.1136/sti.56.5.332

Cited by 19 publications

(7 citation statements)

References 12 publications

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“…Laboratory investigations. Laboratory diagnosis was done by standard methods used previously (2,3). After the first 17 men were examined, the specimens for culture for C. trachomatis were immediately placed into 2-sucrose phosphate transport medium and frozen at -70°C within 30 min.…”

Section: Methodsmentioning

confidence: 99%

Failure of norfloxacin to eradicate Chlamydia trachomatis in nongonococcal urethritis

Bowie¹,

Willetts²,

Sibau³

1986

Antimicrob Agents Chemother

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Norfloxacin has some activity in vitro against Chiamydia trachomatis and Ureaplasma urealyticum, although not at levels attainable in serum. In this study, norfloxacin was administered (400 mg orally twice daily for 10 days) to men with acute nongonococcal urethritis. Of 25 men from whom C. trachomatis was initially isolated, 21 had the organism reisolated at the first follow-up visit posttreatment, and there were minimal changes in the number of inclusion-forming units in culture. Ultimately, all but 1 of the 22 men from whom C. trachomatis was initially isolated and who were monitored became clinical failures within 42 ± 7 days posttreatment. The clinical outcome was significantly better for men from whom U. urealyticum was initially isolated but from whom C. trachomatis was not isolated. Of 27 men, 17 became and stayed culture negative for U. urealyticum at follow-ups, and clinically, 15 no longer had nongonococcal urethritis. Of these 15, all 12 monitored until at least 42 ± 7 days posttreatment remained improved. Of 26 men from whom neither C. trachomatis nor U. urealyticum was initially isolated, 18 improved and all 15 who were monitored until at least 42 ± 7 days posttreatment remained improved. Thus, although norfloxacin attains high levels in urine and has good tissue penetration, it had essentially no activity against chlamydial urethritis in men. It had better, but incomplete, activity against U. urealyticum. For quinolones to show promise in vivo against C. trachomatis, either the MICs will need to be much lower or the levels attained in serum will have to be much higher.The search for an antimicrobial agent active against the major bacterial genital pathogens continues. Norfloxacin at 600 mg orally, with the same dose repeated 4 h later, was highly effective in vivo against penicillin-susceptible and -resistant Neisseria gonorrhoeae (4). The in vivo activity of norfloxacin against Chlamydia trachomatis and genital mycoplasmas is not known. In vitro, the MICs of norfloxacin against C. trachomatis (1, 5, 6, 8, 9, 13) and Ureaplasma urealyticum (1) have been 8 to 64 ,ug/ml. These levels exceed those attainable in serum, but because norfloxacin has good tissue penetration, urinary levels exceed the MICs, and in vitro results do not always accurately predict in vivo efficacy, a recent review concluded that norfloxacin should be evaluated for activity in nongonococcal urethritis (7). In this study, norfloxacin (400 mg orally twice daily for 10 days) was administered to men with acute nongonococcal urethritis and its clinical and microbiological efficacy was evaluated. compounds, and subsequently had a negative urethral culture for N. gonorrhoeae. MATERIALS AND METHODSProtocol. Men were administered a standard questionnaire, and a genital exam which included stripping the urethra from the base to the meatus at least three times was performed to detect urethral discharge and other abnormalities. A calcium alginate endourethral swab was then inserted 3 to 4 cm into the urethra for culture for C. trachomatis....

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Section: Methodsmentioning

confidence: 99%

Failure of norfloxacin to eradicate Chlamydia trachomatis in nongonococcal urethritis

Bowie¹,

Willetts²,

Sibau³

1986

Antimicrob Agents Chemother

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“…4 Patients with NGU who harbour neither C trachomatis nor U urealyticum show the poorest clinical response to treatment. 5 The macrolide antibiotic, erythromycin, also gives good results in the treatment of NGU.…”

Section: Introductionmentioning

confidence: 99%

Rosaramicin and tetracycline in the treatment of non-gonococcal urethritis. A comparison of clinical and microbiological results.

Darne¹,

Ridgway²,

Oriel³

1982

Sexually Transmitted Infections

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SUMMARY The clinical and microbiological outcome of the treatment of 94 men for uncomplicated non-gonococcal urethritis (NGU) was studied. Rosaramicin 250 mg six hourly for seven days was given to 46 men and tetracycline 250 mg six hourly for seven days to 48 men; the follow-up period was up to six weeks. Complete resolution of the clinical signs of infection was seen in 40 (87%) of the men treated with rosaramicin and in 37 (77%) of those treated with tetracycline. Chlamydia trachomatis was eliminated from 17 of the 18 men treated with rosaramicin and from all of the 16 men treated with tetracycline. Ureaplasma urealyticum was eliminated from 12 of the 14 men treated with rosaramicin and from 15 of the 19 receiving tetracycline. Clinical recovery correlated well with the elimination of C trachomatis but less well with that of U urealyticum. The two antimicrobial agents were equally effective in the therapy of NGU, but gastrointestinal side effects were significantly more common in men treated with rosaramicin.

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“…Microbiologic cure rates ranged from 45% to 77%, with similar rates for both drugs [26][27][28][29]. A small number of observational studies involving women suggest that U. urealyticum biovar 2 isolates may exhibit reduced susceptibility to tetracyclines relative to U. parvum [30][31][32], but further studies are needed.…”

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confidence: 99%

Expanding the Spectrum of Pathogens in Urethritis: Implications for Presumptive Therapy?

Manhart¹,

Golden²,

Marrazzo³

2007

Clinical Infectious Diseases

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Tetracycline in nongonococcal urethritis. Comparison of 2 g and 1 g daily for seven days.

Cited by 19 publications

References 12 publications

Failure of norfloxacin to eradicate Chlamydia trachomatis in nongonococcal urethritis

Failure of norfloxacin to eradicate Chlamydia trachomatis in nongonococcal urethritis

Rosaramicin and tetracycline in the treatment of non-gonococcal urethritis. A comparison of clinical and microbiological results.

Expanding the Spectrum of Pathogens in Urethritis: Implications for Presumptive Therapy?

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