Tetracycline and Its Analogues: a Therapeutic Paradigm in Periodontal Diseases

Weinberg, Mea A.; Bral, Michael

doi:10.1177/10454411980090030501

Cited by 13 publications

(3 citation statements)

References 80 publications

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“…Studies performed by Golub and co‐workers have helped to elucidate the ability of MMP inhibitors to block tissue destruction in patients with periodontal disease (reviewed in Refs. 22 and 23).…”

Section: Blocking Of Periodontal Tissue Destruction By Matrix Metallomentioning

confidence: 99%

C‐Telopeptide Pyridinoline Cross‐Links: Sensitive Indicators of Periodontal Tissue Destruction

Giannobile

1999

Annals of the New York Academy of Sciences

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C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.Periodontal disease is initiated by microbial pathogens that elicit a host immune response with subsequent tissue destruction of the periodontal structures. 1 Patients afflicted with periodontitis experience breakdown of alveolar bone, periodontal ligament, and tooth root cementum. Uncontrolled periodontal tissue destruction eventually leads to tooth loss. A challenge in periodontology is the accurate and early assessment of tissue breakdown in patients with periodontal disease. Current methods of disease detection lack diagnostic sensitivity and specificity. Periodontal diagnostic procedures address several important functions, which include: screening; diagnosis of specific periodontal diseases; identification of sites or subjects at increased risk of experiencing progression of periodontal destruction; treatment planning; and monitoring of therapy. 2 This paper focuses on the ability of the class of molecules known as the pyridinoline crosslinks to identify tooth sites or subjects at an increased risk of experiencing periodontal tissue destruction. Research will be reviewed in preclinical and clinical investigations that illustrate the relationship among pyridinoline cross-links, periodontal pathogens, and alveolar bone loss. The paper concludes with recent developments in the inhibition of periodontal tissue destruction by matrix metalloproteinase (MMP) inhibitors such as doxycycline. PYRIDINOLINE CROSS-LINKS:BIOCHEMISTRY AND CLINICAL CORRELATIONSPyridinoline cross-links have emerged as very promising biomarkers of bone resorption in an array of osteolytic diseases. Pyridinoline (hydroxylysl pyridinoline or Pyr) and deoxypyridinoline (lysyl pyridinoline or Dpy), N-telopeptides, and C-telopeptides have been the best studied members of this class of collagen-degradative molecules. links formed by lysyl oxidase on lysine and hydroxylysine residues in the N-and C-terminal regions of collagen chains. This process results in the formation of divalent collagen crosslinks that by further condensation yield trivalent Pyr and Dpy.Osteoclastic bone resorption initiates the release of cross-linked immunoreactive telopeptides Pyr and Dpy. Urinary levels of Pyr and ...

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Section: Blocking Of Periodontal Tissue Destruction By Matrix Metallomentioning

confidence: 99%

C‐Telopeptide Pyridinoline Cross‐Links: Sensitive Indicators of Periodontal Tissue Destruction

Giannobile

1999

Annals of the New York Academy of Sciences

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“…The members of tetracycline family are among the most important broad spectrum antibiotics, generally safe, well tolerated with fewer side effects [29]. Minocycline HCl a semi synthetic tetracycline [30] is one of the most active antibiotics for microorganisms associated with periodontitis [31,32].…”

Section: Characteristics Of Minocycline Hclmentioning

confidence: 99%

Local Delivery of Minocycline Hydrochloride: A Therapeutic Paradigm in Periodontal Diseases

Javed¹,

Kohli

2010

CDD

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From the literature we can draw conclusions regarding the local use of minocycline in periodontal diseases. This review article attempts to evaluate the role of local delivery of minocycline HCl in the management of periodontal diseases. The efficacies of several local delivery devices of minocycline like minocycline films, strips, gels/ointment, microspheres and nanoparticles are discussed. The functional characteristics of local delivery devices of minocycline, their effectiveness as monotherapy, and comparison with scaling and root planning (SRP) are discussed in detail. Methods for the analysis of minocycline in various biological fluids, clinical trials and patents relevant to the local use of minocycline HCl in dental diseases have also been addressed in the article, conceptualizing the fact that direct application of minocycline into the diseased periodontal sulcus is an attractive treatment approach.

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“…With the widespread interest in the use of systemic and locally‐delivered antimicrobial agents to treat periodontitis ( Slots & Rams 1990, Smith et al 1994, Needleman et al 1995, Mombelli & Winkelhoff 1997, Greenstein & Polson 1998), measurement of periodontal pocket drug concentrations has become increasingly utilised. The tetracyclines have been used extensively as adjuncts to the management of periodontitis ( Listgarten et al 1978, Lindhe et al 1983, Newman et al 1994, Haffajee et al 1995, Needleman et al 1998a, Weinberg 1998).…”

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confidence: 99%

A rapid spectrophotometric assay for tetracycline in gingival crevicular fluid

Needleman¹,

Grahn²,

Pandya³

2001

J Clinic Periodontology

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Aim: The aim of this study was to investigate a rapid spectrophotometric assay for its potential to measure tetracycline levels in gingival crevicular fluid (GCF). Materials and methods: The technique involves complexation of tetracycline with molybdenum in order to shift the absorbance spectrum away from that region where interference with plasma proteins is a problem. The sensitivity of the assay and reproducibility of elution were examined together with an assessment of the effect of plasma proteins. The assay was also tested in a small pilot clinical project, measuring tetracycline levels in GCF following placement of a test gel formulation in 25 periodontal pockets in 5 patients. Results: The in vitro results showed good sensitivity of the assay over the concentration range tested (0.5–200 μg tetracycline) and with little effect of plasma proteins. Elution from the paper strips was reproducible with a good linear correlation between direct and filter absorbed assays (r=0.9989, p<0.01). The pilot clinical study indicated a mean half‐time of tetracycline in GCF of 28 min with confidence intervals of 21 to 34 min, although wide variation between the drug levels of individual periodontal pockets was seen. Conclusions: The results indicate good sensitivity for this assay to measure tetracycline hydrochloride in vivo. The potential for rapidly processing large numbers of samples contrasts with the assay time and limited sample throughput of other methods such as high pressure liquid chromatography (HPLC) and suggests that the technique may be a useful addition to current techniques for measuring tetracycline hydrochloride in vivo.

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Tetracycline and Its Analogues: a Therapeutic Paradigm in Periodontal Diseases

Cited by 13 publications

References 80 publications

C‐Telopeptide Pyridinoline Cross‐Links: Sensitive Indicators of Periodontal Tissue Destruction

C‐Telopeptide Pyridinoline Cross‐Links: Sensitive Indicators of Periodontal Tissue Destruction

Local Delivery of Minocycline Hydrochloride: A Therapeutic Paradigm in Periodontal Diseases

A rapid spectrophotometric assay for tetracycline in gingival crevicular fluid

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