Tetracycline, Aminoglycoside, Macrolide, and Miscellaneous Antibiotics

Mitscher, Lester A.

doi:10.1002/0471266949.bmc088.pub2

Burger's Medicinal Chemistry and Drug Discovery 2010

DOI: 10.1002/0471266949.bmc088.pub2

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Tetracycline, Aminoglycoside, Macrolide, and Miscellaneous Antibiotics

Lester A. Mitscher

Abstract: The identity, chemistry, biosynthesis, antimicrobial spectra, molecular mode of action, bacterial resistance mechanisms, side effects, and clinical uses of these important chemotherapeutic agents are discussed.

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2013

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Cited by 2 publications

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Aminoglycoside Antibiotics

Kirst

Marinelli

2013

Antimicrobials

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Aminoglycosides were the second major antibiotic class to be discovered from fermentation of microorganisms. They are structurally characterized by an aminocyclitol that is substituted in several different patterns by amino-and/or neutral sugar moieties. They are potent, bactericidal, water-soluble compounds that are given by parenteral administration. They are especially useful for treatment of infections caused by Gram-negative bacteria, including Pseudomonas aeruginosa. Limitations of the class include the development of microbial resistance by a variety of mechanisms and patient toxicity, especially nephrotoxicity and ototoxicity. Several semi-synthetic derivatives have been developed that have improved features, especially increased activity against resistant strains of bacteria. The newest aminoglycoside, plazomicin, is a semi-synthetic derivative of sisomicin that is undergoing further evaluation in clinical trials.

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Aminoglycoside Antibiotics

Kirst

Marinelli

2013

Antimicrobials

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Macrolide Antibiotics

Kirst

2013

Antimicrobials

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Tetracycline, Aminoglycoside, Macrolide, and Miscellaneous Antibiotics

Abstract: The identity, chemistry, biosynthesis, antimicrobial spectra, molecular mode of action, bacterial resistance mechanisms, side effects, and clinical uses of these important chemotherapeutic agents are discussed.

Cited by 2 publications

References 368 publications

Aminoglycoside Antibiotics

Aminoglycoside Antibiotics

Macrolide Antibiotics

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