Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: The protective role of chlorogenic acid

Polyphenols as possible bioprotectors against cytotoxicity and DNA damage induced by ochratoxin A

“…Luteolin, chlorogenic and caffeic acids are natural antioxidant compounds and different in vitro and in vivo studies have reported their ability as ROS scavengers (Lin et al, 2008;Sato et al, 2011;Xu et al, 2014). It could be that these polyphenols have exerted their protective effect of damage induced by OTA on cells through an antioxidant mechanism.…”

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

“…Several marker genes were dysregulated, including Nqo1 , Cyp1a2 and Fmo1 . Nqo1 encodes an antioxidant protection enzyme that is often up-regulated in livers of rodents exposed to hepatotoxicity-inducing chemicals and a strong indicator of liver injury [25][26]. So too, Cyp1a2 , an Aryl hydrocarbon receptor (AHR)-responsive hepatic CYP gene, is a well-established liver marker for adaptive metabolic response to xenobiotics, likely serving to protect against hepatocellular damage and inflammation [27].…”

The therapeutic detoxification of chlorogenic acid against acetaminophen-induced liver injury by ameliorating hepatic inflammation

“…In the previous studies, CGA has been reported to prevent liver injuries induced by tetrachlorobenzoquinone, griseofulvin, ischemia/reperfusion, and lipopolysaccharide [14][15][16][17]. In addition, our previous study has showed that CGA prevented AP-induced liver injury in mice when it was orally given for consecutive 7 days before AP intoxication [18].…”