Tetracaine derivatives for catecholaminergic polymorphic ventricular tachycardia: New drugs for correction of diastolic Ca 2+ leak?

Valdivia, Héctor H.; Valdivia, Carmen R.

doi:10.1016/j.hrthm.2018.01.022

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…The example of tetracaine suggests that the answer is "no". Tetracaine was shown to abolish spontaneous Ca 2+ release-its prolonged application caused a rebound activation of diastolic Ca 2+ release because of the inhibition of diastolic Ca 2+ leak resulting in elevated SR Ca 2+ content and consequently higher SOICR propensity [102,[128][129][130]. However, a similar undesirable phenomenon was not observed using flecainide, carvedilol, or dantrolene.…”

Section: Tetracaine Derivativesmentioning

confidence: 99%

Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases

Szentandrássy

Magyar

Hevesi

et al. 2022

IJMS

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Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and identify new therapeutic targets. Cardiac ryanodine receptor (RyR2), the Ca2+ release channel of the sarcoplasmic reticulum, is believed to be a good therapeutic target in a group of certain heart diseases, collectively called cardiac ryanopathies. Ryanopathies are associated with the impaired function of the RyR, leading to heart diseases such as congestive heart failure (CHF), catecholaminergic polymorphic ventricular tachycardia (CPVT), arrhythmogenic right ventricular dysplasia type 2 (ARVD2), and calcium release deficiency syndrome (CRDS). The aim of the current review is to provide a short insight into the pathological mechanisms of ryanopathies and discuss the pharmacological approaches targeting RyR2.

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Section: Tetracaine Derivativesmentioning

confidence: 99%