Tetrabromoepifenchone: a convenient precursor for the synthesis of chiral bicyclo[2.2.1]heptane and bicyclo[2.1.1]hexane derivatives

Ryzhenko, Olga O.; Gorichko, Marian V.

doi:10.1016/j.tetasy.2015.06.012

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Scheme 8 Miscellaneous Examples Of Bcb Opening To Form Bchs1

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2023

2024

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Cited by 3 publications

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“…These starting materials (108, 110, 112, and 114) typically come from terpenoids; therefore, the enantiospecific syntheses of BCHs 109, 111, 113, and 115 are possible. [115][116][117][118][119] The significant drawback of this method is the limited tolerance for substituents (e.g. methyl group) on BCHs.…”

Section: Scheme 8 Miscellaneous Examples Of Bcb Opening To Form Bchsmentioning

confidence: 99%

Recent Progress in Accessing Multi-functionalized Caged Hydrocarbons: En Route to Highly Functionalized Saturated (Bio)isosteres of Benzene Rings

Nagasawa,

Iwabuchi

2024

Synthesis

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Recently, many saturated bioisosteres of benzene ring have been developed, and their application in drug development has been evaluated. Most of these are caged hydrocarbons, which have rigid skeletons and three-dimensional spaces. Recent efforts to synthesize these caged hydrocarbons have enabled access to multi-functionalized congeners that are expected to be (bio)isosteres of multi-functionalized benzenes. This review article summarizes recently reported methods to obtain multi-functionalized (typically more than disubstituted) caged hydrocarbons.

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