Tetrabromobisphenol A, hexabromocyclododecane isomers and polybrominated diphenyl ethers in foodstuffs from Beijing, China: Contamination levels, dietary exposure and risk assessment

Wang, Jiandi; Zhao, Xuezhen; Wang, Yifei; Shi, Zhixiong

doi:10.1016/j.scitotenv.2019.02.324

Cited by 52 publications

(25 citation statements)

References 57 publications

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“…The EDI-estimation resulted similar for Europe and Asia and comparable with levels generally estimated for the same groups of compounds in common food of animal origin worldwide (Ding et al 2018;Giovanoulis et al 2018;Poma et al 2017bPoma et al , 2018Qian et al 2017;Wang et al , 2019Yang et al 2018). However, when making this comparison, it is important to consider that the estimated dietary intake can vary strongly among countries, likely due to differences in dietary habits of the population, number, and typology of food items included in the food categories as well as individual targeted compounds considered within a group of chemicals, etc.…”

Section: Evaluation Of Chemical Safety Of Edible Insectssupporting

confidence: 79%

Occurrence of Selected Organic Contaminants in Edible Insects and Assessment of Their Chemical Safety

Poma

Yin

Tang

et al. 2019

Environ Health Perspect

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BACKGROUND: Feeding the continuously growing world population is challenging, and edible insects offer a sustainable alternative to conventional sources of animal proteins. As with any food source, the potential presence of hazardous organic chemicals, such as persistent organic pollutants (POPs), plasticizers and flame retardants (FRs), must be investigated to guarantee consumer chemical safety. OBJECTIVES: Here, we have investigated the contamination levels of several classes of organic compounds in edible insects. To evaluate their chemical safety, a dietary exposure risk assessment was then performed by combining the measured chemical contamination with the most recent food consumption data from local surveys. METHODS: Insect samples, belonging to six orders (Orthoptera, Coleoptera, Lepidoptera, Hemiptera, Odonata, Hymenoptera) were purchased from five European and three Asian countries. POPs and halogenated FRs were analyzed by gas chromatography-mass spectrometry (GC/MS) and organophosphorus FRs and plasticizers were quantified by liquid chromatography-MS/MS, according to validated protocols. RESULTS: The overall levels of chemical contamination varied greatly among the insect orders and country of purchase, but they were generally low and comparable with other commonly consumed animal products. DISCUSSION: Here we show that, besides the activities during rearing, the industrial post-harvesting handling and addition of ingredients are supplementary factors influencing the chemical load of the final insect food-product. The total estimated dietary intakes of the considered classes of compounds through insect consumption are comparable with those generally assessed in common food of animal origin worldwide and, when compared with existing reference dose values, suggest that the risk of adverse health effects from exposure to the targeted organic compounds via insect consumption is unlikely.

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Section: Evaluation Of Chemical Safety Of Edible Insectssupporting

confidence: 79%

Occurrence of Selected Organic Contaminants in Edible Insects and Assessment of Their Chemical Safety

Poma

Yin

Tang

et al. 2019

Environ Health Perspect

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“…TBBPA and TBBPA-BDBPE have been frequently detected in various environmental matrices, including air, soil, water, sediment, and indoor/outdoor dust, with concentrations ranging from parts per billion (ppb) to parts per million (ppm). − Given their lipophilic property with high octanol–water partition coefficients (Log K ow ), TBBPA (Log K ow = 7.20) and TBBPA-BDBPE (Log K ow = 11.52) readily accumulate in biological organisms . The accumulation of these compounds has been reported in samples of gull eggs, marine mollusks, marine fishes, and animal-based foods. − The ubiquitousness of TBBPA and TBBPA-BDBPE in environmental compartments and foodstuffs indicates that humans can be exposed to these compounds orally.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Tetrabromobisphenol A and Its Derivative in the Mouse Liver Following Oral Exposure at Environmentally Relevant Levels

Yao

Wang

Shi

et al. 2021

Environ. Sci. Technol.

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As typical brominated flame retardants (BFRs), tetrabromobisphenol A (TBBPA) and its derivative TBBPA-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE) are ubiquitous in various environmental compartments. However, the potential health risk posed by these compounds, especially at environmentally relevant levels, remains unclear. In this study, using adult male mice, we investigated the toxicity of orally administered TBBPA and TBBPA-BDBPE at an environmentally relevant dose (57 nmol/kg body weight). After a single exposure and daily exposure, we assessed lipid metabolism homeostasis, the transcriptome, and immune cell components in the liver. We found that the single exposure to TBBPA or TBBPA-BDBPE alone increased the number of hepatic macrophages, induced alterations in the levels of lipids, including triacylglycerol and free fatty acids, and caused transcriptome perturbation. The results from the daily administration groups showed that TBBPA and TBBPA-BDBPE both significantly increased the triacylglycerol content; however, the elevation of hepatic macrophages was observed only in the TBBPA-BDBPE treatment group. This study confirmed that environmentally relevant levels of TBBPA and TBBPA-BDBPE are toxic to the liver. Our findings revealed that dysfunction of the liver is a health concern, following exposure to BFRs, even at very low concentrations. The chronic effects induced by TBBPA and its derivatives should be further investigated.

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“…The estimated total absorption doses from oral and dermal exposure pathways (whole-body dermal absorption and hand-to-mouth ingestion) were 2–3 orders of magnitude higher than that of diet ingestion of ∑ 8 PBDEs (9.8 × 10 –6 mg/kg·d) for adults in Beijing, China, BDE-209 (7.4 × 10 –6 mg/kg·d) for adults in Laizhou Bay, North China and ∑ 10 PBDEs (9.5 × 10 –7 mg/kg·d) for adults in Guangzhou, China, highlighting dermal uptake as a significant exposure pathway for HFRs and PCBs. Males showed relatively higher whole-body dermal absorption doses of BDE-209 (1.4 × 10 –5 mg/kg·d) and DBDPE (1.9 × 10 –4 mg/kg·d) than females (1.3 × 10 –5 and 1.1 × 10 –4 mg/kg·d, respectively) ( p = 0.755 and p = 0.798), and males also showed higher oral ingestion doses through hand-to-mouth contact for BDE-209 (4.7 × 10 –7 mg/kg·d), DBDPE (5.8 × 10 –7 mg/kg·d), and PentaCB (1.2 × 10 –7 mg/kg·d) than females (1.9 × 10 –7 , 1.5 × 10 –7 , and 2.9 × 10 –8 mg/kg·d) ( p = 0.001, 0.001, and 0.001) (Figure S7).…”

Section: Resultsmentioning

confidence: 88%

Halogenated Organic Pollutant Residuals in Human Bared and Clothing-Covered Skin Areas: Source Differentiation and Comprehensive Health Risk Assessment

Cao

Chen

Zhu

et al. 2019

Environ. Sci. Technol.

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To comprehensively clarify human exposure to halogenated flame retardants (HFRs) and polychlorinated biphenyls (PCBs) through dermal uptake and hand-to-mouth intake, skin wipe samples from four typical skin locations from 30 volunteers were collected. The total concentration of the target chemicals (24 HFRs and 16 PCBs) ranged from 203 to 4470 ng/m 2 . BDE-209 and DBDPE accounted for about 37 and 40% of ∑ 24 HFRs, respectively, and PCB-41 and PCB-110 were the dominant PCB congeners, with proportion of 24 and 10%, respectively. Although exhibiting relatively lower concentrations of contaminants than bared skin locations, clothing-covered skin areas were also detected with considerable levels of HFRs and PCBs, indicating clothing to be a potentially significant exposure source. Significant differences in HFR and PCB levels and profiles were also observed between males and females, with more lower-volatility chemicals in malebared skin locations and more higher-volatility compounds in clothing-covered skin locations of female participants. The mean estimated whole-body dermal absorption doses of ∑ 8 HFRs and ∑ 16 PCBs (2.9 × 10 −4 and 6.7 × 10 −6 mg/kg•d) were 1−2 orders of magnitude higher than ingestion doses via hand-to-mouth contact (6.6 × 10 −7 and 3.1 × 10 −7 mg/kg•d). The total noncarcinogenic health risk resulted from whole-body dermal absorption and oral ingestion to ∑ 7 HFRs and ∑ 16 PCBs were 5.2 and 0.35, respectively.

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Tetrabromobisphenol A, hexabromocyclododecane isomers and polybrominated diphenyl ethers in foodstuffs from Beijing, China: Contamination levels, dietary exposure and risk assessment

Cited by 52 publications

References 57 publications

Occurrence of Selected Organic Contaminants in Edible Insects and Assessment of Their Chemical Safety

Occurrence of Selected Organic Contaminants in Edible Insects and Assessment of Their Chemical Safety

Toxicity of Tetrabromobisphenol A and Its Derivative in the Mouse Liver Following Oral Exposure at Environmentally Relevant Levels

Halogenated Organic Pollutant Residuals in Human Bared and Clothing-Covered Skin Areas: Source Differentiation and Comprehensive Health Risk Assessment

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