Tetraarylphosphonium salt-catalyzed formal [3+2] cycloaddition between epoxides and trichloroacetonitrile for the synthesis of β-amino alcohol derivatives

Abstract

Efficient regioselective synthesis of β-amino alcohol derivatives, including enantioenriched ones, by tetraarylphosphonium salt-catalyzed coupling reaction of epoxides with trichloroacetonitrile is described. Formal [3+2] cycloaddition followed by hydrolysis proceeded smoothly to...