Tetra-arsenic oxide (Tetras) enhances radiation sensitivity of solid tumors by anti-vascular effect

Inhibition of STAT3/VEGF/CDK2 axis signaling is critically involved in the antiangiogenic and apoptotic effects of arsenic herbal mixture PROS in non-small lung cancer cells

“…Thus, Trisenox as a trade name of arsenic trioxide from Cephalon Biopharmaceutical Company has been applied to treat acute promyelocytic leukemia (APL) as a chemotherapeutic agent approved by the US FDA [ 15 ]. Recently tetraarsenic hexoxide(As 4 O 6 ) showed antitumor effect more effectively than arsenic trioxide in HPV 16-positive SiHa cervical cancer [ 16 ] and enhanced radiation sensitivity to reduce the growth of Meth-A induced fibrosarcoma and nasopharyngeal squamous cancer implanted in Balb/c nu/nu mice [ 17 ]. Nevertheless, new combination therapy has been attractive with low dose of arsenic trioxide and natural compounds such as naringenin [ 18 ], resveratrol [ 19 ], retinoic acid [ 20 ] and lipoic acid [ 21 ], since the toxicity and poisoning of arsenic trioxide were reported as cardiac toxicity [ 22 , 23 ], reproductive toxicity [ 24 ], hepatotoxicity [ 25 ] and resistance [ 26 , 27 ].…”

Bioactive Poly(Arsenic) Compounds

“…In particular, tetraarsenic oxide suppressed the tubulin polymerization in the presence and absence of paclitaxel in a concentration-dependent manner, indicating a synergic interaction and good potential for the following in vivo evaluation (Chung et al 2009). It was also reported during the first study of the enhanced activity shown by tetraarsenic oxide when combined to radiation therapy in the treatment of solid tumors, like fibrosarcoma and human squamous tumor (Park et al 2009). …”

Biomedical Inorganic Polymers

“…In particular, tetraarsenic oxide suppressed the tubulin polymerization in the presence and absence of paclitaxel in a concentration-dependent manner, indicating a synergic interaction and good potential for the following in vivo evaluation (Chung et al 2009). It was also reported during the first study of the enhanced activity shown by tetraarsenic oxide when combined to radiation therapy in the treatment of solid tumors, like fibrosarcoma and human squamous tumor (Park et al 2009). 7.5 Arsenicin A: The First and Only Natural Organic Polyarsenical…”