Tetra- and hexadentate Schiff base ligands and their Ni(II), Cu(II) and Zn(II) complexes. Synthesis, spectral, magnetic and thermal studies

Ismail, Tarek M.; Saleh, Akila A.; Ghamry, Mosad A. El

doi:10.1016/j.saa.2011.10.037

Cited by 36 publications

(15 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As illustrated in Section , the magnetic moment ( μ eff ) is measured at 298 K for the as‐prepared metal‐imine complexes, which shows that μ eff value of 1.73 for VO (II). This value indicates that NBAVO complex was paramagnetic with a distorted square pyramidal geometry, unlike the μ eff of the Pd (II) complex, which was unmeasurable, thereby confirming its diamagnetic properties …”

Section: Resultssupporting

confidence: 78%

See 1 more Smart Citation

Novel azomethine Pd (II)‐ and VO (II)‐based metallo‐pharmaceuticals as anticancer, antimicrobial, and antioxidant agents: Design, structural inspection, DFT investigation, and DNA interaction

Abu‐Dief

Abdel‐Rahman

Shehata

et al. 2019

J of Physical Organic Chem

View full text Add to dashboard Cite

The new NO bidentate imine ligand, namely, (2‐[(3‐nitro‐benzylidene)‐amino]‐benzoic acid) (NBA) imine ligand (L), and its Pd (II) and VO (II) complexes have been synthesized and characterized by utilizing different physiochemical methods including elemental analyses, Fourier transform infrared (FT‐IR), nuclear magnetic resonance (NMR), molar conductance, and magnetic susceptibility measurements. The stability constant of these complexes has also been determined. In studies of these complexes, they were found to have [M(L)] composition where the ligand acts as a bidentate and coordinates with the various metal ions through azomethine and one oxygen atom. Moreover, the suggested geometrical structure of Pd (II) and VO (II) complexes is square planar and a distorted square pyramid, respectively. Density functional theory (DFT) calculations for the different metal complexes were studied and show a good agreement with the experiment data. The minimum inhibitory concentration method has been applied to evaluate the in vitro antimicrobial activity. Furthermore, the interaction of calf thymus DNA with the metal‐imine chelates has been assessed, and Pd (II) complex showed the strongest interaction with DNA for a binding constant value of (9.72 × 104 kcal mol−1). The cytotoxic activity of the new metal chelates has been evaluated against three human cancer cell lines (hepatic carcinoma HepG2 cells, breast carcinoma cells MCF‐7, and colon carcinoma cells HCT‐116). It has found that NBAPd complex exhibited a significant decrease in the time and dose of the cell viability than did the reference drug vinblastine. The antioxidant activity of the tested compounds was determined and compared with that of vitamin C as a standard drug. It has been found that the metal complexes exhibit higher activity than the free ligand. The finding from this investigation revealed that the new compounds are considered to be prospective antibiotic and anticancer agents.

show abstract

Section: Resultssupporting

confidence: 78%

“…The comparatively low values of ( A ) revealed the slow nature of pyrolysis reaction of the chelates. The greater positive amount of ( E *) demonstrates that the procedures involved translational, rotational, and vibrational states besides changes in mechanical potential energy for metal chelates …”

Section: Resultsmentioning

confidence: 98%

Novel azomethine Pd (II)‐ and VO (II)‐based metallo‐pharmaceuticals as anticancer, antimicrobial, and antioxidant agents: Design, structural inspection, DFT investigation, and DNA interaction

Abu‐Dief

Abdel‐Rahman

Shehata

et al. 2019

J of Physical Organic Chem

View full text Add to dashboard Cite

show abstract

“…However, the 13 C NMR spectrum of Zn(II) and Cd(II) complexes shows a slight shift in their signals and resonates at δ 161.41–161.48 ppm, δ 173.41–173.50 ppm, and δ 154.82–155.12 ppm mainly due to azomethine carbon (HC=N) [27], carbonyl carbon (C=O), and aromatic carbons (Ar-OH), respectively.…”

Section: Resultsmentioning

confidence: 99%

Spectral Characterization and 3D Molecular Modeling Studies of Metal Complexes Involving the O, N-Donor Environment of Quinazoline-4(3H)-one Schiff Base and Their Biological Studies

Siddappa

Mane

Manikprabhu

2014

The Scientific World Journal

View full text Add to dashboard Cite

A simple condensation of 3-amino-2-methylquinazoline-4-one with 2-hydroxy-1-naphthaldehyde produced new tridentate ONO donor Schiff base ligand with efficient yield. The structural characterization of ligand and its Cu(II), Ni(II), Co(II), Mn(II), Zn(II), and Cd(II) complexes were achieved by the aid of elemental analysis, spectral characterization such as (UV-visible, IR, NMR, mass, and ESR), and magnetic data. The analytical and spectroscopic studies suggest the octahedral geometries of Cu(II), Co(II), Ni(II) and Mn(II) complexes and tetrahedral geometry of Zn(II) and Cd(II) complexes with the tridentate ONO Schiff base ligand. Furthermore, the conclusions drawn from these studies afford further support to the mode of bonding discussed on the basis of their 3D molecular modeling studies by considering different bond lengths, bond angles, and bond distance. The ligand and its metal complexes evaluated for their antimicrobial activity against Staphylococcus aureus (MTCC number 7443), Bacillus subtilis (MTCC number 9878), Escherichia coli (MTCC number 1698), Aspergillus niger (MTCC number 281), and Aspergillus flavus (MTCC number 277). The MIC of these compounds was found to be most active at 10 μg/mL concentration in inhibiting the growth of the tested organisms. The DNA cleavage activity of all the complexes was studied by gel electrophoresis method.

show abstract

“…The magnetic measurements for all Co(II) and Ni(II) complexes showed magnetic moment values of 4.3-5.3 and 2.88-3.6 BM respectively, suggesting consistency with their octahedral environment [35]. The Cu(II) complexes 7,8 and 9 showed the magnetic moment values of 2.05 and 2,2.1 BM respectively expected for one unpaired electron, which offers the possibility of a distorted octahedral or square planner geometry [39].The measured effective magnetic values for the Cu-complexes, some what higher than spin-only value .…”

Section: Magnetic Propertiesmentioning

confidence: 80%

“…The application of derivative plots showing the rate of mass change as a function of temperature or time (derivative thermogravimetry, DTG) are useful in attempting to resolve overlapping processes and to determine the point at which the mass loss is most significant, also it useful for some methods of calculation the thermodynamic parameters [35].…”

Section: Thermo Gravimetric Analysesmentioning

confidence: 99%

Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex

Ismail¹

2015

View full text Add to dashboard Cite

Abstract:Novel solid Co(II), Ni(II), Cu(II) and Zn(II) complexes of sulpha drug Schiff base ligand (HL) derived from condensation of sulphaquinoxaline and naphthaldehyde namely, 2-{4-[(2-hydroxynaphthalen-1-yl) methyleneamino] benzenesulfonamido} quinoxalin (HNMABSQ), in addition new mixed ligand complexes with 8-hydroxyquinoline (8-HQ) or 1,10 Phenanthroline (1,10 Phen) with HL and these metal (II) ions were synthesized. The structure of complexes were proposed in light of analytical, IR, 1 H-NMR, Mass, UV-Vis, ESR spectral data, magnetic and thermal studies. The molar conductance data reveal that all the metal chelates were non-electrolytes. The kinetic and thermodynamic parameters for decomposition steps in Co(II), Ni(II) and Cu(II) complexes thermo grams were calculated. On the basis of these studies, most complexes have octahedral geometry but few can attain the square planar arrangement. 3D modeling of the ligand and its metal complexes were studied by PM3 method, also the heat of formations, HOMO, LUMO and dipole moments were calculated to confirm the geometry of the ligand and its complexes. Schiff base ligand and its metal complexes were tested for antimicrobial activities. Nano-Cu-Schiff base complex was synthesized and characterized by scanning electron microscopy (SEM) and its biological activities were studied. The Cu nano complex had higher antibacterial and antifungal activity than the ligand and its metal complexes. Also, all tested compounds inhibited the growth of the liver cancer cell.

show abstract

Tetra- and hexadentate Schiff base ligands and their Ni(II), Cu(II) and Zn(II) complexes. Synthesis, spectral, magnetic and thermal studies

Cited by 36 publications

References 47 publications

Novel azomethine Pd (II)‐ and VO (II)‐based metallo‐pharmaceuticals as anticancer, antimicrobial, and antioxidant agents: Design, structural inspection, DFT investigation, and DNA interaction

Novel azomethine Pd (II)‐ and VO (II)‐based metallo‐pharmaceuticals as anticancer, antimicrobial, and antioxidant agents: Design, structural inspection, DFT investigation, and DNA interaction

Spectral Characterization and 3D Molecular Modeling Studies of Metal Complexes Involving the O, N-Donor Environment of Quinazoline-4(3H)-one Schiff Base and Their Biological Studies

Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex

Contact Info

Product

Resources

About