Tetanus immunisation in the elderly population.

Reid, Patrick A.; Brown, D. C.; Coni, Nicholas; Sama, Andrew E.; Waters, Marilyn

doi:10.1136/emj.13.3.184

Cited by 22 publications

(11 citation statements)

References 7 publications

(2 reference statements)

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“…Antibody concentrations are low in people over 60, especially women. 10 Titers of antibodies to tetanus toxoid are inadequate to ensure protection in about half of people >65 y, who might represent an inadequately immunized segment of the society because of poor access to primary health care. All elderly people should have completed a primary immunization schedule with diphtheria and tetanus toxoid, and thereafter a booster dose is required every 10 y.…”

mentioning

confidence: 99%

Vaccines for the elderly need to be introduced into the immunization program in India

Verma

Khanna

Chawla

2014

Human Vaccines & Immunotherapeutics

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confidence: 99%

Vaccines for the elderly need to be introduced into the immunization program in India

Verma

Khanna

Chawla

2014

Human Vaccines & Immunotherapeutics

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“…In 70% der Fälle sind die Patienten älter als 50 Jahre, zudem verläuft die Erkrankung in diesem Kollektiv zu 80% tödlich [17,28,36]. Zwar weisen in Deutschland 95% der Kinder im Vorschulalter heute einen protektiven Impfschutz auf, jedoch nur 65% der 30-bis 39-Jährigen und sogar weniger als 40% der über 70-Jährigen [30,31]. Das bedeutet, dass durch eine generelle, zunehmende Impfmüdigkeit bei geringer Prä-senz des Tetanus insbesondere die Altersgruppe mit der größten Letalitätsrate auch das höchste Erkrankungsrisiko trägt (.…”

Section: Epidemiologieunclassified

Behandlungsstrategien des Tetanus

Duning

Schäbitz

2007

Nervenarzt

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“…Serological surveys have demonstrated an increasing proportion of patients with inadequate immunity as age increases: 49% -66% of patients over 60 years had antibody levels below the protective level. [4][5][6]…”

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confidence: 99%

“…[3] Serological surveys have demonstrated an increasing proportion of patients with inadequate immunity as age increases: 49% -66% of patients over 60 years had antibody levels below the protective level. [4][5][6] Some have never been vaccinated, while others have lost their immunity. [7] Tetanus is an important endemic infection in India.…”

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confidence: 99%

A Study to Evaluate the Adverse Reaction of Tetanus Vaccine (Adsorbed) in Healthy Indian Adults

Rao¹,

A²,

Z³

2018

jemds

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BACKGROUND Tetanus disease is one of the most dramatic and globally prevalent diseases of humans and vertebrate animals and has been reported for over 24 centuries. The manifestation of the disease, spastic paralysis, is caused by the second most poisonous substance known as the tetanus toxin. According to the World Health Organisation, India had reported 70,335 cases of Tetanus in the period from 2000 -2015, of these 17,025 cases were neonatal tetanus. Serological surveys have demonstrated an increasing proportion of patients with inadequate immunity as age increases: 49% -66% of patients over 60 years had antibody levels below the protective level. [4][5][6] MATERIALS AND METHODSThis was a single arm, uncontrolled clinical trial study to evaluate the adverse events following Tetanus Vaccine (Adsorbed) in healthy adult subjects. Total 39 healthy individuals consented for the study and after exclusion criteria all eligible were e nrolled into the study, i.e. a total of 34 healthy adult subjects aged 18 to 45 years were enrolled into the study. All selected individuals were admitted as IP for evaluation of the adverse reactions for 3 days and follow-up till 28 days. Single dose of the Tetanus Vaccine (Adsorbed) 0.5 mL was administered as deep intramuscular injection into the deltoid region. Observation period was 28 days after vaccination. There were no antibody estimation done in this trial. Local and systemic reactions were collected for 28 days following injection using Diary Card (i.e. Day 0 to Day 28). All AEs, SAEs and AEs that lead to withdrawal from the study and related prescription vaccines were collected for the entire study period. RESULTSThe study population consisted of 34 healthy adult subjects aged between 18 and 45 years. All subjects received the study vaccine and hence the safety population consisted of all (100%) vaccinated subjects. CONCLUSIONThis was a single arm study designed to evaluate the safety and tolerability of Tetanus Vaccine (Adsorbed) in healthy adult subjects. A total of 34 healthy adult subjects aged 21 to 44 years were enrolled into the study. A total of 39 subjects were screened for the study. Of these, 34 subjects received the study vaccine.

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Tetanus immunisation in the elderly population.

Abstract: (_JAccid EmergMed 1996;13:184-185)

Cited by 22 publications

References 7 publications

Vaccines for the elderly need to be introduced into the immunization program in India

Vaccines for the elderly need to be introduced into the immunization program in India

Behandlungsstrategien des Tetanus

A Study to Evaluate the Adverse Reaction of Tetanus Vaccine (Adsorbed) in Healthy Indian Adults

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