Tetanus Immune Globulin From Selected Human Plasmas

Levine, Leo

doi:10.1001/jama.1967.03120170113032

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Indeed, the selection of donations solely on the basis of the disclosure of such injection(s) within the past year only produced six plasmas with 5 (or more) IU/ml out of 32. This is in keeping with the findings of Levine et al [2] who found only 15 out of 60 by the haemagglutination assay. However, a few individuals maintain readily detectable antitoxin levels even for many years without further known boosting, and would thus be the best donors to identify for the present purposes.…”

Section: Discussionsupporting

confidence: 93%

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The Selection of Plasma for the Preparation of Antitetanus Immunoglobulin

Entwistle¹,

Eldridge²

1973

Vox Sanguinis

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The use of IEOP is described for screening blood donors to find plasma containing tetanus antitoxin suitable for fractionation. Preliminary results indicate that most recipients of tetanus toxoid are unlikely to have acceptable antitoxin levels for much longer than about three months after inoculation. A small number of recipients maintain acceptable levels even for many years without further known boosting. Such people can now be identified easily, among the 5% of all East Anglian donors who have antitoxin levels of at least 5 IU/ml.

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Section: Discussionsupporting

confidence: 93%

“…This is in keeping with the findings of LEVINE rt a/. [2] who found only 15 out of 60 by the haemagglutination assay. However, a few individuals maintain readily detectable antitoxin levels even for many years without further known boosting, and would thus be the best donors to identify for the present purposes.…”

Section: Discussionsupporting

confidence: 92%

The Selection of Plasma for the Preparation of Antitetanus Immunoglobulin

Entwistle¹,

Eldridge²

1973

Vox Sanguinis

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III.—New Developments in Large-scale Plasma Fractionation

Watt

Smith

Grant

et al. 1972

Proc. Sect. B. Biol.

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‘Selective transfusion of appropriate blood components is preferable to the routine use of whole blood.’ (American Association of Blood Banks. Physicians' Handbook of Blood Component Therapy, 1969).The rational use of donor blood in the environment of modern blood transfusion revolves around a series of developments in the field of component therapy. The fractionation of plasma, i.e. the separation of plasma into a series of subdivisions each containing one or other of the constituent proteins in varying degrees of purity and concentration, was one of the first of these developments to become established.Early fractionation of plasma was applied in various ways to the purification of animal antisera; initially to antipneumococcal serum for therapeutic use. These sera frequently provoked reactions in patients until Sabin showed that absorption with Fullers earth could abolish these side-effects by removing complexed molecules.

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The Selection of Plasma for the Preparation of Antitetanus Immunoglobulin

Cc¹,

Pl²

1973

Vox Sanguinis

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Abstract. The use of IEOP is described for screening blood donors to find plasma containing tetanus antitoxin suitable for fractionation. Preliminary results indicate that most recipients of tetanus toxoid are unlikely to have acceptable antitoxin levels for much longer than about three months after inoculation. A small number of recipients maintain acceptable levels even for many years without further known boosting. Such people can now be identified easily, among the 5% of all East Anglian donors who have antitoxin levels of at least 5 1U/ml.

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Tetanus Immune Globulin From Selected Human Plasmas

Cited by 4 publications

References 11 publications

The Selection of Plasma for the Preparation of Antitetanus Immunoglobulin

The Selection of Plasma for the Preparation of Antitetanus Immunoglobulin

III.—New Developments in Large-scale Plasma Fractionation

The Selection of Plasma for the Preparation of Antitetanus Immunoglobulin

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