TET proteins regulate Drosha expression and impact microRNAs in iNKT cells
Marianthi Gioulbasani,
Tarmo Aijo,
Jair Ernesto Valenzuela
et al.
Abstract:DNA demethylases TET2 and TET3 play a fundamental role in thymic invariant natural killer T (iNKT) cell differentiation by mediating DNA demethylation of genes encoding for lineage specifying factors. Paradoxically, differential gene expression analysis revealed that significant number of genes were upregulated upon TET2 and TET3 loss in iNKT cells. This unexpected finding could be potentially explained if loss of TET proteins was reducing the expression of proteins that suppress gene expression. In this study… Show more
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