Modified gravity theories are supposed to incorporate low-energy quantum-gravity effects and, at the same time, they could shed light into the dark matter and dark energy problems. Here we study a particular modification of general relativity where local Lorentz invariance is spontaneously broken and whose physical effects, despite a decade-long effort, were unknown. We show that, during inflation, this modification produces anisotropies that would generate measurable effects on the Cosmic Microwave Background. Then, by using empirical constraints on the B-mode polarization spectrum, we can estimate that the 'coefficient' components absolute value have to be smaller than 10 −43 . This is a remarkably strong limit, in fact, it is 29 orders of magnitude better than the best constraints on similar coefficients. Thus, we propose that inflation could stringently test other modified gravity theories.The quest for a gravity theory that is compatible with quantum mechanics and that, at the same time, can explain the nature of dark matter and dark energy, has lead to consider modified theories of gravity [1]. These modifications come in very different forms; the common feature is that they are supposed to provide a better description of Nature and to produce small effects in regimes where the current theories have been tested. In particular, these modified theories should describe the Universe evolution from the onset of inflation since this epoch is usually assumed to be correctly described by general relativity.Amongst the majority of cosmologists, inflation, an early era in which the Universe underwent an accelerated expansion, is held as an essential part of the standard ΛCDM cosmological model. Historically, it was conceived to solve the flatness and horizon problems of the standard Big Bang model. However, its current success is based on the power to explain the primordial inhomogeneities generation that represent the seeds of cosmic structure [2][3][4][5][6]. Furthermore, the latest Planck satellite data release indicates that inflation correctly characterizes the early Universe [7][8][9]. In particular, this data suggests that the primordial perturbations spectrum is essentially scale invariant, favoring the simplest inflationary models [9,10].In this work, we study, during the inflationary regime, a modified gravity theory that violates local Lorentz invariance. Recall that local Lorentz invariance is one of the basic tenets of general relativity and it states that there are no preferred spacetime directions. Moreover, * bonder@nucleares.unam.mx † gleon@fcaglp.unlp.edu.ar our main motivation for considering Lorentz violation relies on studies, within prominent quantum gravity candidates, that argue that Lorentz violation may occur at the quantum gravity regime (see, e.g., Refs. 11 and 12). A systematic program to look for Lorentz violation revolves around the general parametrization known as the Standard Model Extension (SME) [13][14][15]. Remarkably, this program has led to significant bounds on many parameters...