Tests of Glycemia in Diabetes

Goldstein, David E.; Little, Randie R.; Lorenz, Rodney A.; Malone, John I.; Nathan, David M.; Peterson, Charles M.; Sacks, David B.

doi:10.2337/diacare.27.7.1761

Cited by 550 publications

(401 citation statements)

References 163 publications

(63 reference statements)

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“…36 Since then, the change in HbA 1c levels has been used as an index of glycemic control for both research and diabetic patients. 37 The HbA 1c level (6:4 AE 0:5%) in the [VO(tpps)]-treated STZ mice decreased significantly (p < 0:001) compared to that (9:9 AE 0:5%) of the saline-treated STZ mice, indicating a significant improvement of diabetic state in STZ mice treated with [VO(tpps)].…”

Section: Metallokinetic Features Of Oxovanadium(iv)-porphyrin Complexmentioning

confidence: 93%

“…The oxovanadium(IV)-porphyrin complexes ([VO(tmpyp)]: 1 mM; [VO(tpps)]: 1 mM) were mixed with 4% bovine serum albumin in saline solution (2 mL) in a stoppered sample tube which was then shaken in a water bath at 37 C for 48 h. The oxovanadium(IV) state of the porphyrin complexes in 4% bovine serum albumin was monitored by ESR at room temperature by withdrawing a small aliquot (200 mL) from the solution. The stability of the oxovanadium(IV) complexes was also studied in the fresh blood serum of rats, which was used instead of 4% bovine serum albumin.…”

Section: Methodsmentioning

confidence: 99%

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Oxovanadium(IV)–Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−)

Saha¹,

Yoshikawa²,

Yasui³

2006

Bulletin of the Chemical Society of Japan

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We prepared and characterized [meso-tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4À), [VO(tpps)], and its in vitro insulin-mimetic activity, metallokinetic features in the blood of healthy rats, and in vivo hypoglycemic effect in streptozotocin (STZ)-induced diabetic mice (STZ mice) were investigated. The results were compared with those of previously proposed insulin-mimetic [meso-tetrakis(1-methylpyridinium-4-yl)porphyrinato]oxovanadium(IV)(4+), [VO(tmpyp)], and vanadium(IV) oxide sulfate. The in vitro insulin-mimetic activity, the retention time and bioavailability of [VO(tpps)] in blood were considerably better than those of [VO(tmpyp)] and vanadium(IV) oxide sulfate. [VO(tpps)] caused a significant hypoglycemic effect in STZ mice within 8 h following a single oral administration of the complex at 15 mg V/kg of body mass without ascorbate; this effect was sustained for at least 60 h. [VO(tpps)] normalized the hyperglycemia of STZ mice within 2 days when administered orally at 4-10 mg V/kg of body mass for 18 days. Vanadium, as determined by instrumental neutron activation analysis, was distributed in the tissues examined in the following decreasing order: bones, kidneys, liver, lungs, spleen, heart, pancreas, muscles, fatty pads, and brain. The improvement in diabetes was supported by oral glucose tolerance test, HbA 1c level and blood pressure. Based on the above results, [VO(tpps)] is an orally active oxovanadium(IV)-porphyrin complex for treating type 1 diabetic animals.

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Section: Metallokinetic Features Of Oxovanadium(iv)-porphyrin Complexmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Oxovanadium(IV)–Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−)

Saha¹,

Yoshikawa²,

Yasui³

2006

Bulletin of the Chemical Society of Japan

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“…The use of portable glucometers by patients at home, along with laboratory tests conducted by health professionals [8], remain the two most common methods for blood glucose monitoring in patients with type 2 diabetes (T2D). While regular self-monitoring of blood glucose (SMBG) levels using glucometers is regarded as an essential tool for self-care [2,9–11], tests performed in accredited laboratories are preferred for confirming diagnoses, and are used in clinical and therapeutic decision making [2].…”

Section: Introductionmentioning

confidence: 99%

Blood glucose monitoring in type 2 diabetes – Nepalese patients’ opinions and experiences

Sapkota

Brien

Aslani

2017

Global Health Action

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Background: Blood glucose monitoring forms a vital component of diabetes care. Monitoring conducted at home using glucometers, and in laboratories by professionals, are two common methods of blood glucose monitoring in clinical practice. Objective: To investigate Nepalese patients’ perceptions and practices of blood glucose monitoring in diabetes. Methods: In-depth interviews were conducted with 48 Nepalese participants with type 2 diabetes in Sydney and Kathmandu. The interviews were audio-recorded, transcribed verbatim and thematically analysed. Results: In Australia, most participants perceived home monitoring as useful; and both home and laboratory monitoring were conducted at fairly regular intervals. In Nepal, only a small number conducted home monitoring and the laboratory method formed the primary method of day-to-day monitoring. The laboratory method was preferred due to easy access to laboratories, lack of faith in glucometers and perceptions that home monitoring is costlier. However, overall monitoring was irregular in Nepal. In addition to the healthcare system which enabled cheaper self-monitoring in Australia, Nepalese in Australia also tended to have a better understanding about the purpose of home monitoring. Conclusions: This study has highlighted the disparity in perceptions and practices related to blood glucose monitoring. Understanding the importance of blood glucose monitoring and access to affordable resources are critical facilitators for conducting regular monitoring. Both patient and health-system factors play a key role in ensuring continued diabetes monitoring and management.

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“…İdrarda keton, keton stripleri ile bakılmaktadır. Son yıllarda geliştirilen glukometreler ile kan keton düzeyi ölçülebilmektedir 20,21,22 . Glikolizillenmiş Hemoglobin (HbA1C): Glisemik kontrolün uzun dönemde değerlendirilmesi için en kullanışlı ölçüm glikozillenmiş hemoglobindir.…”

Section: Diyabet Tedavisi Ve Kontrolünde Diyabetlinin Bireyselunclassified

Home Care Applications and Management in Children with Type 1 Diabetes

Ergün¹,

Sivrikaya²

2012

BSBD

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Tests of Glycemia in Diabetes

Cited by 550 publications

References 163 publications

Oxovanadium(IV)–Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−)

Oxovanadium(IV)–Porphyrin Complex as a Potent Insulin-Mimetic. Treatment of Experimental Type 1 Diabetic Mice by the Complex [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadate(IV)(4−)

Blood glucose monitoring in type 2 diabetes – Nepalese patients’ opinions and experiences

Home Care Applications and Management in Children with Type 1 Diabetes

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