Tests for bactericidal effects of antimicrobial agents: technical performance and clinical relevance.

Peterson, Lance R.; Shanholtzer, Carol J.

doi:10.1128/cmr.5.4.420-432.1992

Cited by 2 publications

(2 citation statements)

References 76 publications

(125 reference statements)

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“…Estimation of bactericidal activity presents, however, certain limitations that may be summarized as follows: (i) the time interval between drug administration and fluid sampling; (ii) the size of the applied inoculum; and (iii) the applied diluent. 17 Concentrations of moxifloxacin in CSF in humans were assessed in the present study in a setting of absence of meningeal inflammation. Previous experimental studies of meningitis in rabbits caused by S. pneumoniae and E. coli revealed that penetration of moxifloxacin was very satisfactory through the inflamed meninges, 5,6 reaching concentrations equal to those reported here.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of moxifloxacin in non-inflamed cerebrospinal fluid of humans: implication for a bactericidal effect

Kanellakopoulou

Pagoulatou

Stroumpoulis

et al. 2008

Journal of Antimicrobial Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of moxifloxacin in non-inflamed cerebrospinal fluid of humans: implication for a bactericidal effect

Kanellakopoulou

Pagoulatou

Stroumpoulis

et al. 2008

Journal of Antimicrobial Chemotherapy

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“…Moreover, a report from literature reflects that mycobacteria have a lipid-rich hydrophobic cell wall and are often susceptible to less polar compounds [45]. According to Peterson & Shanholtzer [46], bacteriostatic activity has been defined as a ratio of MBC to MIC of > 4. Thus, essential oil exhibited bactericidal activity.…”

Section: Batesiimentioning

confidence: 99%

Density Functional Theory of a New Derivative of Allantoin with Antiplasmodial Properties, Antimycobacterial Activities of Essential Oil from Cordia Batesii WERNHAM (Boraginaceae)

Tiam

Bikobo

Ndassa

et al. 2020

Preprint

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Background: some chemical and pharmacological investigations were performed on the EtOAc and/or CH2Cl2 extracts of the stems of Cordia batesii (Boraginaeae); one of its components was subjected to some quantum calculations to get improvement in the understanding of its 13C–NMR and UV properties along with geometric, electronic, thermodynamic data and reactivity descriptors. Results: a new allantoin (1) derivative named batesiin (2) was characterized from the EtOAc extract; thirteen known compounds including allantoin (1) were either isolated or identified by means of MS, NMR, LC–MS and GC–MS. GC–MS was applied on a fraction of essential oil which was composed of a mixture of fatty acids (9–14). Density functional theory (DFT) calculations were applied on batesiin (2). Data were simulated using B3LYP and MPW1PW91 functionals; calculated chemical shifts at B3LYP/6–31G(d,p) and MPW1PW91/6–31G+(d,p) showed much better correlations with the experimental data. Time dependent DFT applied on 2 at B3LYP/6–31G+(d,p) displayed a major absorption band at λmax = 299.01 nm using chloroform as solvent, 3.01 nm higher than the experimental value. In addition, The MeOH extract of the stems and some isolated compounds were tested in vitro against Pf7G8 CQS and Pf Dd2 CQR strains of Plasmodium falciparum; meanwhile, the CH2Cl2 extract and the mixture of fatty acids (9–14) were tested on a resistant mycobacterial strain of Mycobacterium tuberculosis codified AC45. Stems disclosed a moderate antiplasmodial activity (IC50 = 50 μg/mL) and the mixture 9–14 a potent antimycobacterial activity with a MIC = 9.52 μg/mL.Conclusion: these results tend to emphasize on the use of DFT studies when trying to learn more about the chemical structure through spectroscopic data of a natural compound, especially the case of a derivative of allantoin (1); essential oil from Cordia batesii presents interesting antimycobacterial activities which need to gain more visibility; further antiplasmodial tests should rely on batesiin (2) and other components of the species.

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Tests for bactericidal effects of antimicrobial agents: technical performance and clinical relevance.

Cited by 2 publications

References 76 publications

Pharmacokinetics of moxifloxacin in non-inflamed cerebrospinal fluid of humans: implication for a bactericidal effect

Pharmacokinetics of moxifloxacin in non-inflamed cerebrospinal fluid of humans: implication for a bactericidal effect

Density Functional Theory of a New Derivative of Allantoin with Antiplasmodial Properties, Antimycobacterial Activities of Essential Oil from Cordia Batesii WERNHAM (Boraginaceae)

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