TESTOSTERONE Β-Cyclopentylpropionate: A NEW LONG-ACTING ANDROGEN

Ott, A. C.; Kuizenga, Marvin H.; Lyster, Stanley C.; Johnson, Byron A.

doi:10.1210/jcem-12-1-15

Cited by 13 publications

(4 citation statements)

References 16 publications

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“…The results of the observations herein reported confirm and extend those of other investigators who have studied some of these testosterone esters (5–12).…”

Section: Discussionsupporting

confidence: 91%

Studies Comparing the Effects of Certain Testosterone Esters in Man*,†

Reifenstein

Howard

Turner

et al. 1954

J American Geriatrics Society

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“…The results of the observations herein reported confirm and extend those of other investigators who have studied some of these testosterone esters (5–12).…”

Section: Discussionsupporting

confidence: 91%

Studies Comparing the Effects of Certain Testosterone Esters in Man*,†

Reifenstein

Howard

Turner

et al. 1954

J American Geriatrics Society

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“…Aside from the possibility that mice may respond differently than rats to testosterone during erythropoietic suppression, the apparent discrepancy may be attributed to the dose level of testosterone employed. While pharmacologic doses were given in these former reports, a single physiologic dose of TCP was employed in the present study as judged by the ability of this hormone to maintain the secondary sex organs of orchidectomized rats of same strain (Ott et al 1952). That the dose level of hormone may be crucial in predicting and animal's response is better exemplified by the observation that in dogs (Gordon et al 1968), as well as in rabbits and mice (Mirand et al 1965), greater erythropoietic responses were elicited by moderate than by high levels of testosterone.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Testosterone on Erythropoiesis

Rencricca

Solomon

Fimian

et al. 1969

Scandinavian Journal of Haematology

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The erythropoietic effect of testosterone cyclopentylpropionate (TCP) was studied in normal, plethoric, nephreetomized and ureter‐ligated rats. The results of this study support the contention that TCP exerts its erythropoietic effect though the kidney by increasing REF production; thereby potentiating this organ to generate greater amounts of erythropoietin (EP) in response to normal and cobalt‐stimulated erythropoietic challenges. From the data, it is further concluded that TCP neither exerts a direct EP‐like effect on haemopoietic tissues nor potentiates the effect of preexisting endogenous EP. The present data does not negate the possibility that testosterone may interfere with the action of an inhibitor of erythropoiesis, possibly at the renal level.

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“…Testosterone cyclopentyl propionate (hereafter called TCP) were invented by Ott et al(1952), and its prolongation and potentiation of the androgenic activity were firstly shown by Sakamoto et al(1951), indicating the increased weight of seminal vesicles and the enlarged size of the levator ani muscle of the TCP treated rats. Clinical trial was made by Lloyd et al(1951).…”

mentioning

confidence: 99%