Testosterone treatment, internalizing symptoms, and body image dissatisfaction in transgender boys

Grannis, Connor; Leibowitz, Scott; Gahn, Shane; Nahata, Leena; Morningstar, Michele; Mattson, Whitney I.; Chen, Diane; Strang, John; Nelson, Eric E.

doi:10.1016/j.psyneuen.2021.105358

Cited by 32 publications

(43 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Grannis et al. ( 2021 ) demonstrated transgender males who started testosterone had lower internalizing mental health symptoms (depression and anxiety) compared with those who had not started testosterone treatment.…”

Section: Chapter 6 Adolescentsmentioning

confidence: 99%

“…However, transgender identity is not a mental illness, and these elevated rates have been linked to complex trauma, societal stigma, violence, and discrimination (Nuttbrock et al., 2014 ; Peterson et al., 2021 ). In addition, psychiatric symptoms lessen with appropriate gender-affirming medical and surgical care (Aldridge et al., 2020 ; Almazan and Keuroghlian; 2021; Bauer et al., 2015 ; Grannis et al., 2021 ) and with interventions that lessen discrimination and minority stress (Bauer et al., 2015 ; Heylens, Verroken et al., 2014 ; McDowell et al., 2020 ).…”

Section: Chapter 18 Mental Healthmentioning

confidence: 99%

See 1 more Smart Citation

Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

Coleman

Radix

Bouman

et al. 2022

International Journal of Transgender Health

1,006

492

View full text Add to dashboard Cite

Background: Transgender healthcare is a rapidly evolving interdisciplinary field. In the last decade, there has been an unprecedented increase in the number and visibility of transgender and gender diverse (TGD) people seeking support and gender-affirming medical treatment in parallel with a significant rise in the scientific literature in this area. The World Professional Association for Transgender Health (WPATH) is an international, multidisciplinary, professional association whose mission is to promote evidence-based care, education, research, public policy, and respect in transgender health. One of the main functions of WPATH is to promote the highest standards of health care for TGD people through the Standards of Care (SOC). The SOC was initially developed in 1979 and the last version (SOC-7) was published in 2012. In view of the increasing scientific evidence, WPATH commissioned a new version of the Standards of Care, the SOC-8. Aim: The overall goal of SOC-8 is to provide health care professionals (HCPs) with clinical guidance to assist TGD people in accessing safe and effective pathways to achieving lasting personal comfort with their gendered selves with the aim of optimizing their overall physical health, psychological well-being, and self-fulfillment. Methods: The SOC-8 is based on the best available science and expert professional consensus in transgender health. International professionals and stakeholders were selected to serve on the SOC-8 committee. Recommendation statements were developed based on data derived from independent systematic literature reviews, where available, background reviews and expert opinions. Grading of recommendations was based on the available evidence supporting interventions, a discussion of risks and harms, as well as the feasibility and acceptability within different contexts and country settings. Results: A total of 18 chapters were developed as part of the SOC-8. They contain recommendations for health care professionals who provide care and treatment for TGD people. Each of the recommendations is followed by explanatory text with relevant references. General areas related to transgender health are covered in the chapters Terminology, Global Applicability, Population Estimates, and Education. The chapters developed for the diverse population of TGD people include Assessment of Adults, Adolescents, Children, Nonbinary, Eunuchs, and Intersex Individuals, and people living in Institutional Environments. Finally, the chapters related to gender-affirming treatment are Hormone Therapy, Surgery and Postoperative Care, Voice and Communication, Primary Care, Reproductive Health, Sexual Health, and Mental Health. Conclusions: The SOC-8 guidelines are intended to be flexible to meet the diverse health care needs of TGD people globally. While adaptable, they offer standards for promoting optimal health care and guidance for t...

show abstract

Section: Chapter 6 Adolescentsmentioning

confidence: 99%

Section: Chapter 18 Mental Healthmentioning

confidence: 99%

Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

Coleman

Radix

Bouman

et al. 2022

International Journal of Transgender Health

1,006

492

View full text Add to dashboard Cite

show abstract

“…It is also important to note that while estradiol (female participants only) and DHEA were also collected in the ABCD Study ( Karcher and Barch, 2021 ), we chose to limit our hormonal analyses to testosterone based on prior work linking this hormone to both internalizing symptoms ( Grannis et al, 2021 , Ho et al, 2021 , McHenry et al, 2014 , Zarrouf et al, 2009 ) and reward circuitry ( Forbes et al, 2010 , Goddings et al, 2019 , Ho et al, 2021 , Ladouceur et al, 2019 , Op de Macks et al, 2011 , Op de Macks et al, 2016 , Peper et al, 2013 , Wierenga et al, 2018 ). Moreover, although our sensitivity analysis controlled for saliva time collection, the wide range of sample timing during data collection may still have affected the reliability of the testosterone measurement ( Cheng et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Given existing work linking testosterone levels to both internalizing symptoms ( Grannis et al, 2021 , Ho et al, 2021 , McHenry et al, 2014 , Zarrouf et al, 2009 ) and reward circuitry ( Forbes et al, 2010 , Goddings et al, 2019 , Hermans et al, 2010 , Ho et al, 2021 , Ladouceur et al, 2019 , Op de Macks et al, 2011 , Op de Macks et al, 2016 , Peper et al, 2013 , Wierenga et al, 2018 ), and because this was one of the two hormones collected in both male and female participants in the ABCD Study ( Cheng et al, 2021 ), we chose to focus on testosterone as a hormonal indicator of pubertal development.…”

Section: Methodsmentioning

confidence: 99%

Reward sensitivity and internalizing symptoms during the transition to puberty: An examination of 9-and 10-year-olds in the ABCD Study

McNeilly

Saragosa-Harris

Mills

et al. 2022

Developmental Cognitive Neuroscience

View full text Add to dashboard Cite

“…8,9 The typical clinical approach for adolescent males with CDGP or hypogonadism is the prescription for Testosterone Replacement Therapy (TRT). Currently various choices of interventions for TE replacement and management for adults are available, including intramuscular (IM), subcutaneous, oral and transdermal preparations, [10][11][12][13][14][15] but the right tittered choice and mode of administration of TE for young adults are not available. [16][17][18] Pitfalls in the use of TE usages for adolescents have disclosed multitudes of risks, associated behavioral deviations in the pre pubertal group and below target height line achievement with non-advancement of one's age which has generated a warning for its usage.…”

Section: Introduction Rationalementioning

confidence: 99%

Trans Dermal Testosterone Compared to Intramuscular Testosterone for Young Males with Delayed Puberty: A PRISMA Guided Systematic Review

Jabari¹

2023

IJGM

View full text Add to dashboard Cite

Background: Challenges in selecting the right formulation of testosterone (TE) for young males with delayed puberty (DP) arise from the fact that there is limited evidence based guidelines in recommending the most efficient and safe formulation of TE. Objective: To evaluate the existing evidence and systematically review the interventional effects of transdermal TE to other modes of TE administration for the treatment of DP among young and adolescent males. Methods: All types of methodologies published in English were searched from the data sources including MEDLINE, Embase, Cochrane Reviews, Web of Science, AMED and Scopus from 2015 till 2022. Boolean operators with keywords "types of TE", "modes of TE administration", "DP", "transdermal TE", "constitutional delay of growth and puberty, (CDGP)" "adolescent boys" and "hypogonadism" to optimize the search results. The main outcomes of concern were optimal serum TE level, body mass index, height velocity, testicular volume, pubertal stage (Tanner), The secondary outcomes included in this study were adverse events and patient satisfaction. Results: After screening 126 articles, 39 full texts were reviewed. Only five studies could be included after careful screening and rigid quality assessments. Most studies were at high or unclear risk of bias with short duration and follow up periods. Only one study was a clinical trial covering all the outcomes of interests. Conclusion:This study points out the favorable effects of transdermal TE treatment for DP in boys, while the existence of the vast gap in research needs to be acknowledged. Despite the utmost demand in an appropriate TE treatment for young males with DP, scarce efforts and trials are being undertaken to provide clear clinical guidance of treatment. Quality of life, cardiac events, metabolic parameters, coagulation profiles are important aspects of the treatment are overlooked and under evaluated in most studies. Systematic Review Registration: PROSPERO CRD 42022369699.

show abstract

Testosterone treatment, internalizing symptoms, and body image dissatisfaction in transgender boys

Cited by 32 publications

References 49 publications

Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

Reward sensitivity and internalizing symptoms during the transition to puberty: An examination of 9-and 10-year-olds in the ABCD Study

Trans Dermal Testosterone Compared to Intramuscular Testosterone for Young Males with Delayed Puberty: A PRISMA Guided Systematic Review

Contact Info

Product

Resources

About