Testosterone Therapy in Women

Dunsmoor-Su, Rebecca; Fuller, Ashley; Voedisch, Amy

doi:10.1097/aog.0000000000004566

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…One of our key reflections during the development of the sessions was that there remains a dearth of pharmacologic options for FSD that are widely available and covered by insurance. 30 This was one of the key challenges identified by participants during the sessions and remains an area where more viable options are needed. We note that the pharmacology treatment section of these resources can evolve and hope that the section will require frequent updating as new treatment options arrive.…”

Section: Discussionmentioning

confidence: 99%

Female Sexual Dysfunction: A Primer for Primary Care Health Professionals

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Female Sexual Dysfunction: A Primer for Primary Care Health Professionals

et al. 2023

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“…So far, a large majority of TRT studies have been centered on men, but there are a growing number of studies dealing with the therapeutic use of T in women [ 596 , 597 , 598 ]. The ease with which T is aromatized to E2 is a fundamental aspect to consider when using TRT in women, despite their quantitative needs of T being apparently lower than in men.…”

Section: Current Pharmacological Utilization Of Androgensmentioning

confidence: 99%

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

Alemany

2022

IJMS

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Androgens are an important and diverse group of steroid hormone molecular species. They play varied functional roles, such as the control of metabolic energy fate and partition, the maintenance of skeletal and body protein and integrity and the development of brain capabilities and behavioral setup (including those factors defining maleness). In addition, androgens are the precursors of estrogens, with which they share an extensive control of the reproductive mechanisms (in both sexes). In this review, the types of androgens, their functions and signaling are tabulated and described, including some less-known functions. The close interrelationship between corticosteroids and androgens is also analyzed, centered in the adrenal cortex, together with the main feedback control systems of the hypothalamic–hypophysis–gonads axis, and its modulation by the metabolic environment, sex, age and health. Testosterone (T) is singled out because of its high synthesis rate and turnover, but also because age-related hypogonadism is a key signal for the biologically planned early obsolescence of men, and the delayed onset of a faster rate of functional losses in women after menopause. The close collaboration of T with estradiol (E2) active in the maintenance of body metabolic systems is also presented Their parallel insufficiency has been directly related to the ravages of senescence and the metabolic syndrome constellation of disorders. The clinical use of T to correct hypoandrogenism helps maintain the functionality of core metabolism, limiting excess fat deposition, sarcopenia and cognoscitive frailty (part of these effects are due to the E2 generated from T). The effectiveness of using lipophilic T esters for T replacement treatments is analyzed in depth, and the main problems derived from their application are discussed.

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“…Now, I would like to address multiple recent publications in the literature that have promoted these inaccurate perceptions. The first is a recent clinical commentary published in Obstetrics & Gynecology by Dunsmoor-Su et al [ 34 ]. There were several inaccuracies presented in this paper.…”

Section: Recent Publications—perceptions May Not Align With Realities...mentioning

confidence: 99%

A Personal Prospective on Testosterone Therapy in Women—What We Know in 2022

Donovitz

2022

JPM

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Hormone replacement therapy continues to be a controversial topic in medicine, with certain narratives regarding safety concerns that are not scientifically established in peer-reviewed literature. These negative narratives, specifically undermining the use of testosterone in women, have caused women to remain without any Food and Drug Administration (FDA)-approved testosterone therapies, while more than 30 FDA-approved testosterone therapies are available for men in the United States. This has resulted in millions of women suffering in silence with very common symptoms of perimenopause and menopause that could easily be addressed with the use of testosterone. There is growing evidence to support the use of physiologic doses of testosterone for sexual function, osteoporosis prevention, brain protection, and breast protection. The safety of testosterone use in women has been evaluated for the past 80 years. A recent publication on the complications of subcutaneous hormone-pellet therapy, looking at a large cohort of patients over 7 years, demonstrated long-term safety. In addition, there have been two large long-term peer-reviewed studies showing a significant reduction in the incidence of invasive breast cancer in women on testosterone therapy. Perhaps it is time for the FDA to consider approving products that would benefit testosterone-deficient women.

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Testosterone Therapy in Women

Cited by 5 publications

References 20 publications

Female Sexual Dysfunction: A Primer for Primary Care Health Professionals

Female Sexual Dysfunction: A Primer for Primary Care Health Professionals

The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health

A Personal Prospective on Testosterone Therapy in Women—What We Know in 2022

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