Testosterone therapy for prevention and reversal of type 2 diabetes in men with low testosterone

Caliber, Monica; Saad, Farid

doi:10.1016/j.coph.2021.04.002

Cited by 22 publications

(13 citation statements)

References 52 publications

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“…This large population-based study confirmed that men with IFG and IGT have reduced total T serum levels, similarly to T2DM, regardless of total body fat, body fat distribution, physical activity, and smoking [61] . This result, although interesting, is partly in contrast with a previous work of Rabijewski et al [46] , which reported lower T in IGT compared to IFG patients. In this scenario, Corona et al [12] detected a stepwise increase in hypogonadism prevalence as a function of glucose abnormalities.…”

Section: Male Hypogonadism Prevalence In Pre-diabetescontrasting

confidence: 99%

“…In particular, the comprehensive evaluation of existing data reveals that androgen therapy leads to a total body fat mass reduction and fat-free mass increase, together with a small decrease in total cholesterol [45] . Similarly, a potential glucose metabolism improvement after androgen replacement therapy is suggested in diabetic men [46][47][48] . Indeed, T replacement therapy reduced HbA1c, fasting plasma glucose levels, and homeostasis model assessment of insulin resistance (HOMA-IR) in T2DM subjects [49] .…”

Section: Effects Of Exogenous Testosterone On Glucose Metabolismmentioning

confidence: 99%

“…Moreover, some of these studies tried to distinguish pre-diabetes in IFG and IGT. Goodman-Gruen et al [61] evaluated 266 prediabetic subjects, highlighting either total T serum levels or bioavailable T serum levels lower in IFG Rabijewski et al [46] , 2016 To investigate the relationships between anabolic hormones and body composition in middle-aged and elderly men with pre-diabetes compared to controls and IGT. This large population-based study confirmed that men with IFG and IGT have reduced total T serum levels, similarly to T2DM, regardless of total body fat, body fat distribution, physical activity, and smoking [61] .…”

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 99%

“…SHBG serum levels were available in nine studies [12,40,46,56,58,60,62,63] . Arthur et al [40] and Boeri et al [58] reported significantly lower SHBG levels in pre-diabetic patients compared to controls.…”

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 99%

“…Similarly, a significant, inverse correlation between SHBG and glucose homeostasis was detected in pre-diabetic men [12] as well as in the subgroup of patients with IFG [61] . However, five studies reported lower SHBG concentrations in euglycemic controls compared to pre-diabetic patients, leaving the association between SHBG serum levels and pre-diabetes unclear [46,56,57,60,62] . In particular, Zhu et al [60] highlighted low SHBG as an independent predictor of pre-diabetes incidence, especially in elderly men and irrespective of total T serum levels.…”

Section: Male Hypogonadism Prevalence In Pre-diabetesmentioning

confidence: 99%

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Male hypogonadism and pre-diabetes interplay: association or causal interaction? A systematic review

Greco¹,

Corleto²,

Ebert³

et al. 2021

MTOD

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Aim:The association between type 2 diabetes mellitus (T2DM) and male hypogonadism has been largely demonstrated. Testosterone (T) serum levels are often lower in men with T2DM compared to the general population, and, conversely, men with higher T serum levels have shown lower risk of T2DM. On the contrary, the association between pre-diabetes and male hypogonadism has been less investigated thus far. Pre-diabetes is a common clinical condition preceding T2DM and has been recognized as a potential risk factor for other metabolic disorders and cardiovascular diseases. Therefore, the aims of this review are to investigate the association between pre-diabetes and male hypogonadism and to evaluate the potential effect of T treatment on glucose metabolism and anti-diabetic therapy on T serum levels. Methods:We conducted this systematic review developing different literature searches, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol.Results: In our analysis, male hypogonadism has a prevalence of around 24%-35% in pre-diabetic men. Moreover, we observed improvement of metabolic parameters in pre-diabetes with T treatment. On the contrary, antidiabetic therapy seems to have no particular effects on T serum levels. Conclusion:Overall, we demonstrated that, although T administration could be considered in pre-diabetic men, pre-diabetes-related treatments should be confined to the control glucose metabolism, since no evidence for a positive effect on total T serum levels is available. Future research should be oriented to study the role of new antidiabetic drugs in the sex hormonal status in hypogonadal men.

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Section: Male Hypogonadism Prevalence In Pre-diabetescontrasting

confidence: 99%