Testosterone synthesis by a Brenner tumor

Brenner Tumours of the Ovary a Clinicopathological Study

“…The sparseness of mitoses, the absence of epithelial anaplasia, invasive growth and metastases, and the favourable course, seem to support the view expressed by Roth and Sternberg (82) that a proliferating Brenner tumour is benign, despite its being some 35 kind of intermediate form. This is in agreement with the recommendations of WHO, with the classification of these tumours as a "borderline" group (102).…”

“…In histochemical studies on tumours of the ovary, hfcKay et a1 (47) concluded that no signs of a hormonal secretion had been observed in Brenner tumours. Besch et al (9) and Hamwi et al (35) described a case in which masculinisation developed during pregnancy in a young primipara with Brenner tumour. In virro incubation of the tumour after its removal revealed that it synthesised testosterone from progesterone only in the presence of human chorionic gonadotrophin.…”

A case of hypertension with virilisation during pregnancy

“…Postcoital haemperitoneum (PH) without an evident vaginal injury is reported only in 19 cases in literature. [1][2][3][4][5][6] Postcoital injuries are usually associated with risk factors such as pregnancy, rough intercourse, coital position, vaginismus, genital disproportion, postmenopausal atrophy, genital operations, uterine retroversion and rape or the use of sexual 'toys'. 4 Commonly, PH without evident vaginal injury is caused by a rupture of a branch of coeliac axis.…”

“…Only five cases of Brenner tumours associated with clinical virilisation have been reported, two during pregnancy and three in postmenopausal women. [3][4][5][6] In pregnancy, it is likely that human chorionic gonadotrophin stimulates production of testosterone by these tumours. In the postmenopausal state, it has been postulated that high LH levels or stimulation of stromal cells by the expanding mass may stimulate production of oestrogen and androgens.…”