Testosterone Suppresses Hepcidin in Men: A Potential Mechanism for Testosterone-Induced Erythrocytosis

Bachman, Eric; Feng, Rui; Travison, Thomas G.; Li, Michelle; Olbina, Gordana; Ostland, V. E.; Ulloor, Jagadish; Zhang, Anqi; Basaria, Shehzad; Ganz, Tomas; Westerman, Mark; Bhasin, Shalender

doi:10.1210/jc.2010-0864

Cited by 201 publications

(113 citation statements)

References 21 publications

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“…In fact, testosterone administration has been associated with the suppression of serum hepcidin, and the reduction in serum hepcidin levels is associated with a greater increase in haematocrit in older men during testosterone therapy. 71 Women with polycystic ovary syndrome, who have decreased oestrogen and increased testosterone levels, also show reduced serum hepcidin levels. 72 Hepcidin is a peptide hormone produced in the liver that binds and degrades the iron channel ferroportin, 73 resulting in an inhibition of bioavailable iron.…”

Section: Testosterone and Erythropoiesismentioning

confidence: 99%

Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes

Gonzales

2013

Asian J Androl

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Populations living at high altitudes (HAs), particularly in the Peruvian Andes, are characterized by a mixture of subjects with erythrocytosis (16 g dl 21 ,haemoglobin (Hb)f21 g dl 21 ) and others with excessive erythrocytosis (EE) (Hb.21 g dl 21 ). Elevated haemoglobin values (EE) are associated with chronic mountain sickness, a condition reflecting the lack of adaptation to HA. According to current data, native men from regions of HA are not adequately adapted to live at such altitudes if they have elevated serum testosterone levels. This seems to be due to an increased conversion of dehydroepiandrosterone sulphate (DHEAS) to testosterone. Men with erythrocytosis at HAs show higher serum androstenedione levels and a lower testosterone/androstenedione ratio than men with EE, suggesting reduced 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity. Lower 17beta-HSD activity via D4-steroid production in men with erythrocytosis at HA may protect against elevated serum testosterone levels, thus preventing EE. The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the D5-pathway. Currently, there are various situations in which people live (human biodiversity) with low or high haemoglobin levels at HA. Antiquity could be an important adaptation component for life at HA, and testosterone seems to participate in this process.

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Section: Testosterone and Erythropoiesismentioning

confidence: 99%

Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes

Gonzales

2013

Asian J Androl

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“…High levels of T rapidly suppress hepcidin in a dose dependent manner. Following TRT instauration, Hb increase is related to the decrease of hepcidin [125].…”

Section: Anemiamentioning

confidence: 98%

“…Androgen related erythropoietic activity seems erythropoietin independent and implicates hepcidin, a liver produced polypeptide [123,125]. Hepcidin induces a reduction of iron intestinal absorption, an increase of iron sequestration in the macrophages and reduced erythropoiesis.…”

Section: Anemiamentioning

confidence: 99%

A view of geriatrics through hormones. What is the relation between andropause and well-known geriatric syndromes?

Samaras

Lang

et al. 2013

Maturitas

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a b s t r a c tAge related male hypogonadism, or "andropause", is increasingly recognized as of frequent occurrence in older patients. Diagnosis requires both the presence of clinical symptoms and low testosterone levels. However, diagnosing andropause in this age group may be challenging since symptoms are frequently non specific and testosterone levels are influenced by a multitude of parameters such as lifestyle factors and chronic diseases. In this article we discuss the pathophysiology, definition and diagnostic difficulties of andropause in geriatric patients. Moreover, we review the relation between testosterone levels and frequent geriatric syndromes such as falls, osteoporosis, cognitive and mood disorders, anemia and cardiovascular disease. Finally, we examine the potential benefits and risks of testosterone replacement therapy in this age group.

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“…However, we observed no differences in either iron status indicators or CRP between males and females, and the gender difference may have other explanations. In adults, testosterone is the major hormone responsible for the observed gender differences in the regulation of iron metabolism (18). Testosterone may repress hepcidin transcription by enhancing epidermal growth factor receptor signaling in the liver (19) or by stimulating erythropoietin production (20).…”

Section: Articlesmentioning

confidence: 99%

Serum hepcidin in infants born after 32 to 37 wk of gestational age

et al. 2015

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Background: Preterm infants are at risk of iron deficiency (ID). Hepcidin has been suggested as a good additional indicator of ID in preterm infants, next to ferritin. Methods: In a prospective observational study, we analyzed serum hepcidin in 111 infants born after 32+0 to 36+6 wk gestational age during the first 4 mo of life. results: Hepcidin concentrations decreased during the first 4 mo of life, and concentrations were lower in infants with ID compared to those without ID. Infants who developed ID at the age of 4 mo had already significantly lower levels of hepcidin at 1.5 mo of age, while ferritin was already significantly lower at the age of 1 wk. conclusion: Hepcidin concentrations of late preterm infants decrease during the first 4 mo of life. This decrease, which parallels a decrease of ferritin concentration, we interpret as a physiological response, aiming to increase iron availability. Hepcidin concentrations are lower in infants with ID compared with those without ID, with a notable change already observed at 1.5 mo of age. Hepcidin can be used as an early marker of ID, although an additive value of hepcidin over ferritin in the diagnosis of ID is not present.

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Testosterone Suppresses Hepcidin in Men: A Potential Mechanism for Testosterone-Induced Erythrocytosis

Abstract: Testosterone administration is associated with suppression of serum hepcidin. Greater increases in hematocrit in older men during testosterone therapy are related to greater suppression of hepcidin.

Cited by 201 publications

References 21 publications

Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes

Serum testosterone levels and excessive erythrocytosis during the process of adaptation to high altitudes

A view of geriatrics through hormones. What is the relation between andropause and well-known geriatric syndromes?

Serum hepcidin in infants born after 32 to 37 wk of gestational age

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