Testosterone, Shbg and Albumin in Patients with Ovarian Carcinoma

Mählck, Carl-Gustav; Grankvist, Kjell; Bäckström, Torbjörn; Kjellgren, Olle

doi:10.3109/00016348609158381

Cited by 19 publications

(8 citation statements)

References 21 publications

(5 reference statements)

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“…The hypoalbuminemia was more pro nounced in cases of advanced disease and decreased even more during the progress of the disease. Interestingly, decrease in total plasma-protein concentration was very gentle, if present at all, which indicates a concomitant increase in the globulin fraction among plasma proteins [2], This is in concordance with the results of a study by our group on testosterone and plasma protein in patients with ovarian carcinoma, where the plasma level of sex hormone-binding globulin (SHBG) was increased in cases with great tumor burden [3].…”

Section: Introductionsupporting

confidence: 80%

Plasma Prealbumin in Women with Epithelial Ovarian Carcinoma

Mählck¹,

Grankvist

1994

Gynecol Obstet Invest

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Background: Epithelial ovarian carcinoma produces steroid hormones that may be of prognostic importance. The steroids are mainly bound to plasma albumin and sex hormone-binding globulin. Alterations in plasma protein levels influence hormonal effects. As plasma prealbumin may reflect changes in the patient’s clinical status better than do albumin determinations, it is of interest to analyze prealbumin in patients with ovarian cancer. Methods: Fifty-one postmenopausal or oophorectomized women with epithelial cancer of the ovary were studied. Plasma prealbumin was analyzed prior to and during chemotherapy. Tumor volumes were evaluated and blood samples were drawn for prealbumin analysis on four occasions at monthly intervals. Plasma levels were compared with one control group of postmenopausal women, one group of fertile women in the follicular phase of the menstrual cycle, and one control group of postmenopausal women with nongynecologic disseminated malignant disease. Results: Prealbumin conentrations are lower in women with carcinoma of the ovary than in postmenopausal controls and the levels correlate inversely to tumor volume. Prealbumin concentrations are decreased in the large tumor group, advanced tumor stage group and in the control group with nongynecologic disseminated malignant disease. During chemotherapy, plasma prealbumin increases concomitantly with the reduction of tumor volume. Initial plasma prealbumin concentration seems to have prognostic importance. Conclusions: Prealbumin may be a sensitive indicator of disturbances in protein metabolism. It may reflect changes in the patient’s clinical status better than do albumin determinations. Prealbumin concentration seems to have a prognostic importance in women with epithelial ovarian carcinoma. Condensation: Prealbumin is studied in women with epithelial ovarian carcinoma prior to and during chemotherapy, and is found to vary inversely with changes in tumor volume.

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Section: Introductionsupporting

confidence: 80%

Plasma Prealbumin in Women with Epithelial Ovarian Carcinoma

Mählck¹,

Grankvist

1994

Gynecol Obstet Invest

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“…Androstenedione and progesterone are present at higher concentrations in the ovarian vein draining the affected ovary when compared with levels found in the vein draining the contralateral, disease-free gland (7,8). Plasma levels of estradiol-17␤ (E 2 ), progesterone, 20␣-hydroxyprogesterone, testosterone, and androstenedione have all been shown to correlate with OC tumor masses (9)(10)(11). Taken together, these findings suggest that steroid hormones are likely involved in the genesis and progression of the disease, yet their mechanisms of action remain unclear.…”

mentioning

confidence: 99%

Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells

Lau

Mok

1999

Proc. Natl. Acad. Sci. U.S.A.

256

161

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Our understanding of the roles played by sex hormones in ovarian carcinogenesis has been limited by a lack of data concerning the mode of sex hormone action in human ovarian surface epithelial (HOSE) cells, the tissue of origin of >90% of ovarian cancers. We have compared the relative abundance of estrogen receptor (ER)␣, ER␤, progesterone receptor (PR), and androgen receptor (AR) mRNA in four primary cultures of HOSE cells obtained from postmenopausal women to those found in late serous adenocarcinoma primary cell cultures and established ovarian cancer cell lines. We observed coexpression of ER␣ and ER␤ mRNA along with AR and PR transcripts in normal HOSE cells and disruption of ER␣ mRNA expression as well as dramatic down-regulation of PR and AR transcript expression in most ovarian cancer cells. In contrast, levels of ER␤ mRNA were unaffected by the malignant state. Additionally, a novel mutation involving a 32-bp deletion in exon 1 of ER␣ transcripts was detected in the SKOV3 cell line. This mutation would explain why SKOV3 was reported to be ER-positive but estrogen-insensitive. Taken together, these findings suggest that estrogens, signaling via either or both ER subtypes, may play an indispensable role in regulating normal HOSE cell functions. Therefore, loss of ER␣, PR, and AR mRNA expression in HOSE cells may be responsible for neoplastic transformation in this cell type. In contrast, the roles played by ER␤ in normal and malignant HOSE cells remain elusive. Finally, the coexistence of mutated ER␣ mRNA and normal ER␤ transcripts in SKOV3 argues in favor of a dependency of ER␤ action on functional ER␣s.

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“…Women with elevated serum levels of androgens have an increased risk of ovarian cancer [44,45], and androgen administration is associated with ovarian cancer in animal models [46]. Ovarian cancer is associated with an increase in androgen production [47]. A coactivator of the AR (AR-associated protein 70, or ARA70) has been found to be up-regulated in ovarian tumors [48].…”

Section: Introductionmentioning

confidence: 99%

The androgen receptor and prostate cancer: A role for sexual selection and sexual conflict?

Summers

Crespi

2008

Medical Hypotheses

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Summary We propose and evaluate the hypothesis that the CAG repeat region of the androgen receptor represents a locus of antagonistic pleiotropy in the context of sexual selection and sexual conflict. Short repeats are associated with increased transactivation of the androgen receptor at the molecular level, and increased fertility at the phenotypic level. However, short repeats are also associated with increased risk of prostate cancer, and with more aggressive forms of the disease. The somatic evolution of cancer cell lineages also shows a repeated pattern of shortening of the CAG repeat in association with cancer progression, apparently as a result of positive selection among cell lineages. We further postulate that other genes associated with prostate cancer are likely to mediate antagonistic pleiotropy in the context of sexual selection and sexual conflict. A key prediction of this hypothesis is that the genes mediating antagonistic pleiotropy will show historical evidence of positive selection, particularly in the context of sexual conflict. Previous research on the molecular evolution of specific genes associated with prostate cancer supports this prediction, and we suggest further critical tests of the role for genomic conflicts and tradeoffs in the evolution of cancer risk.

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Testosterone, Shbg and Albumin in Patients with Ovarian Carcinoma

Cited by 19 publications

References 21 publications

Plasma Prealbumin in Women with Epithelial Ovarian Carcinoma

Plasma Prealbumin in Women with Epithelial Ovarian Carcinoma

Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells

The androgen receptor and prostate cancer: A role for sexual selection and sexual conflict?

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